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中华妇幼临床医学杂志(电子版) ›› 2025, Vol. 21 ›› Issue (02) : 140 -144. doi: 10.3877/cma.j.issn.1673-5250.2025.02.003

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子宫内膜种植窗口期及内膜微生物组与个体化胚胎移植的研究现状
撒沙威1, 马黔红1,()   
  1. 1. 四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2024-12-01 修回日期:2025-03-20 出版日期:2025-04-01
  • 通信作者: 马黔红
  • 基金资助:
    四川省科技厅重点研发项目(2019YFS0419)四川大学横向课题(22 H0602)

Current research status on window of implantation and endometrial microbiota in personalized embryo transfer

Shawei Sa1, Qianhong Ma1,()   

  1. 1. Department of Obstetrics and Gynecology,Key Laboratory of Birth Defects and Related Disseases of Women and Children (Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China
  • Received:2024-12-01 Revised:2025-03-20 Published:2025-04-01
  • Corresponding author: Qianhong Ma
引用本文:

撒沙威, 马黔红. 子宫内膜种植窗口期及内膜微生物组与个体化胚胎移植的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2025, 21(02): 140-144.

Shawei Sa, Qianhong Ma. Current research status on window of implantation and endometrial microbiota in personalized embryo transfer[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2025, 21(02): 140-144.

在辅助生殖技术(ART)中,子宫内膜种植窗口期(WOI)和子宫内膜微生物组,对于胚胎成功植入及成功妊娠至关重要。WOI是指子宫内膜容受性(ER),允许胚胎植入继而妊娠的最佳时间。子宫内膜WOI受损和子宫内膜微生物失衡,均可降低ART 成功率,增加复发性植入失败(RIF)和不良妊娠结局风险。目前存在多种评估子宫内膜WOI和子宫内膜微生物检测(EMT)方法,但是在实际临床应用中,存在诸多限制和挑战。随着个体化胚胎移植(p ET)策略的提出,对精准把握子宫内膜WOI和EMT 的需求日益增加。笔者拟就子宫内膜WOI和内膜微生物组在p ET 中的最新研究现状进行阐述,旨在提升ART 成功率,为未来ART 研究方向提供理论基础和实践指导。

In assisted reproductive technology (ART),the window of implantation(WOI)and endometrial microbiome are crucial for the successful implantation of embryos and pregnancy.WOI refers to endometrial receptivity(ER),which allows the best time for embryo implantation and subsequent pregnancy.Impairments in WOI and microbial imbalances can reduce the success rate of ART and increase the risk of recurrent implantation failures(RIF)and adverse pregnancy outcomes.Although various methods exist to assess endometrial WOI and microenvironment by endometrial microbiological testing (EMT),they face numerous limitations and challenges in clinical application.With the advent of personalized embryo transfer (p ET)strategies,there is an increasing demand for precise understanding and manipulation of the WOIand endometrial microbiome.This review explores recent advancements in study of WOI and endometrial microbiome within context of p ET,aiming to enhance success rate of ART and provide a theoretical foundation and practical guidance for future research directions of ART.

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