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中华妇幼临床医学杂志(电子版) ›› 2025, Vol. 21 ›› Issue (01) : 73 -77. doi: 10.3877/cma.j.issn.1673-5250.2025.01.010

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微小RNA 与子宫内膜异位症的相关研究现状
安春晓1, 彭丽娜1, 张献2, 张广美1,()   
  1. 1. 哈尔滨医科大学妇产科,哈尔滨 150081
    2. 黑龙江中医药大学,哈尔滨 150006
  • 收稿日期:2024-08-03 修回日期:2024-12-25 出版日期:2025-02-01
  • 通信作者: 张广美
  • 基金资助:
    国家自然科学基金面上项目(81971359)黑龙江省自然科学基金联合引导项目(LH2019 H027)哈尔滨市应用技术研究与开发项目(2017AB9BS039)

Current research progress of microRNAs and endometriosis

Chunxiao An1, Lina Peng1, Xian Zhang2, Guangmei Zhang1,()   

  1. 1. Department of Obstetrics and Gynecology,Harbin Medical University,Harbin 150081,Heilongjiang Province,China
    2. Heilongjiang University of Chinese Medicine,Harbin 150006,Heilongjiang Province,China
  • Received:2024-08-03 Revised:2024-12-25 Published:2025-02-01
  • Corresponding author: Guangmei Zhang
引用本文:

安春晓, 彭丽娜, 张献, 张广美. 微小RNA 与子宫内膜异位症的相关研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2025, 21(01): 73-77.

Chunxiao An, Lina Peng, Xian Zhang, Guangmei Zhang. Current research progress of microRNAs and endometriosis[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2025, 21(01): 73-77.

子宫内膜异位症(EMS)是指子宫腔外存在子宫内膜和基质组织,是育龄女性的一种常见良性妇科疾病,可严重影响其生活质量。微小RNA(miRNA)是长度约为22 nt的非编码RNA 分子,通过m RNA 裂解或翻译、抑制,发挥负基因调控作用,在细胞分化、增殖、凋亡、自噬和血管化等多种细胞过程中起着关键作用。miRNA 参与EMS的发生及发展过程,并且在EMS患者和正常育龄女性的在位子宫内膜与异位子宫内膜之间,多个miRNA 表达水平存在显著差异。miRNA 有望成为EMS患者的无创性诊断生物标志物,并且可通过其靶基因及下游信号通路,对EMS患者进行靶向治疗。笔者拟就miRNA 表达差异及miRNA 与雌激素合成、血管形成、EMS相关不孕、EMS恶变的相关关系,以及miRNA 与EMS临床诊治关系的最新研究现状进行阐述。

Endometriosis(EMS)refers to presence of endometrium and stromal tissue outside uterine cavity.It is a common benign gynecological disease in reproductive-aged women,which seriously affects women's quality of life.MicroRNAs (miRNA)are non-coding RNA molecules with a length of approximately 22 nt,which exert negative gene regulation by promoting miRNA degradation or translation and inhibition,playing a crucial role in various cellular processes,such as cell differentiation,proliferation,apoptosis,autophagy,and angiogenesis.miRNA are involved in the occurrence and development of EMS,and there are significant differences in expression levels of multiple miRNA between EMS patients and normal reproductive-aged women with insitu endometrium and ectopic endometrium.miRNA have potential to be non-invasive biomarkers for EMS patients,and can provide targeted treatment for EMS patients through their target genes and downstream signaling pathways.In this review,authors will discuss the latest research findings on expression differences of miRNA,their relationship with estrogen synthesis,angiogenesis,EMS related infertility,EMS malignant transformation,and EMS clinical diagnosis and treatment.

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