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中华妇幼临床医学杂志(电子版)

中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (01) : 58 -61. doi: 10.3877/cma.j.issn.1673-5250.2015.01.013

所属专题： 文献；

论著

先兆子痫患者血清脂肪型脂肪酸结合蛋白与血脂水平监测的临床意义
张文华1,*,*(), 位菊峰1, 李玲1   
  1. 1. 266042　山东省青岛大学医学院第二附属医院（青岛市中心医院）妇产科
  • 收稿日期:2014-08-11 修回日期:2014-12-24 出版日期:2015-02-01
  • 通信作者: 张文华

Clinical significance of monitoring of adipocyte fatty acid-binding protein and blood fat levels in serum of preeclampsia pregnant women

Wenhua Zhang1(), Jufeng Wei1, Ling Li1   

  1. 1. Department of Obstetrics and Gynecology, Second Affiliated Hospital of Qingdao Medical University (Qingdao Central Hospital), Qingdao 266042, Shandong Province, China
  • Received:2014-08-11 Revised:2014-12-24 Published:2015-02-01
  • Corresponding author: Wenhua Zhang
  • About author:
    Corresponding author: Zhang Wenhua, Email:
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引用本文：

张文华, 位菊峰, 李玲. 先兆子痫患者血清脂肪型脂肪酸结合蛋白与血脂水平监测的临床意义[J]. 中华妇幼临床医学杂志(电子版), 2015, 11(01): 58-61.

Wenhua Zhang, Jufeng Wei, Ling Li. Clinical significance of monitoring of adipocyte fatty acid-binding protein and blood fat levels in serum of preeclampsia pregnant women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(01): 58-61.

目的

探讨先兆子痫(PE)患者孕期血清脂肪型脂肪酸结合蛋白(FABP4)与血脂水平监测及其意义。

方法

选择2010年10月至2012年10月在青岛大学医学院第二附属医院(青岛市中心医院)产科确诊为PE的40例孕妇为研究对象，并纳入PE组，再按照PE病情分级将其分别纳入重度PE亚组(SPE亚组，n＝22)和轻度PE亚组(MPE亚组，n＝18)。选择同期于本院常规产前检查的40例健康孕妇纳入对照组。采用酶联免疫吸附测定法(ELISA)及全自动生化仪检测所有受试者血清FABP4、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL)水平，并统计学比较各组间差异及PE组血清FABP4与血脂水平的相关性。PE组与对照组、SPE亚组与MPE亚组受试者平均年龄、孕龄和晚孕期体质量等一般临床资料比较，差异均无统计学意义(P>0.05)。本研究遵循的程序符合青岛大学医学院第二附属医院(青岛市中心医院)人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象知情同意，并与之签署临床研究知情同意书。

结果

①SPE亚组及MPE亚组血清FABP4、TC、TG、及LDL水平均较对照组显著升高，且差异有统计学意义(P<0.01)，而两亚组血清HDL水平则均较对照组显著降低，差异亦有统计学意义(P<0.01)；SPE亚组及MPE亚组血清FABP4、TC、TG、HDL及LDL水平比较，差异均无统计学意义(P>0.05)。②PE患者血清FABP4与TG水平呈正相关(r＝0.86，P<0.01)，而与HDL水平呈负相关(r＝－0.98，P<0.01)。

结论

血清FABP4水平升高和脂质代谢紊乱可能与PE发病有关。

关键词: 先兆子痫, FABP4蛋白，人类, 脂蛋白, 孕妇
Objective

To explore the clinical significance of monitoring of adipocyte fatty acid-binding protein(FABP4) and blood fat levels in serum of preeclampsia(PE) pregnant women.

Methods

A total of 40 pregnant women who diagnosed as PE in department of Obstetric, Second Affiliated Hospital of Qingdao Medical University(Qingdao Central Hospital) from October 2010 to October 2012 were bringing into PE group and 40 healthy pregnant women who made regular prenatal examination in the same hospital were bringing into control group.In accordance with PE classification, PE group was further divided into severe preeclampsia (SPE) subgroup (n=22) and mild preeclampsia (MPE) subgroup (n=18). The serum levels of FABP4, triglyceride(TG), total cholesterol(TC), low density lipoprotein (LDH) and high density lipoprotein(HLD) were detected by enzyme linked immunosorbent assay(ELISA) and full automatic biochemical analyzer, and compared the data between different groups and subgroups, analyzed the correlation between FABP4 and lipoproteins levels in PE group.There were no significant differences between PE and control group, SPE and MPE subgroup in average age, gestational age and late pregnancy body mass(P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Second Affiliated Hospital of Qingdao Medical University(Qingdao Central Hospital). Informed consent was obtained from each participant.

Results

①The serum levels of FABP4, TC, TG and LDL in SPE and MPE subgroup were significantly higher than those in control group, and the differences were statistically significant(P<0.01); while the serum level of HDL in these two subgroups were significantly lower than that in control group, and the differences were statistically significant(P<0.01). There were no significant differences between SPE and MPE subgroup in serum levels of FABP4, TC, TG, HDL and LDL(P>0.05). ②The serum levels of FABP4 and TG had positive correlation in PE group(r=0.86, P<0.01), while the serum levels of FABP4 and HDL had negative correlation in PE group (r=-0.98, P<0.01).

Conclusion

The increased serum level of FABP4 and lipid metabolism disorders may be associated with the pathogenesis of PE.

Key words: Pre-eclampsia, FABP4 protein, human, Lipoproteins, Pregnant women
表1 两组间一般临床资料比较(±s)
Table 1 Comparison of general clinical data between two groups(±s)
组别 例数 年龄(岁) 孕龄(周) 晚孕期体质量(kg)
PE组 40 29.2±4.5 36.9±2.9 86.2±9.1
对照组 40 28.8±2.2 38.1±4.0 82.8±8.0
t值 ? 0.402 1.567 1.775
P值 ? 0.689 0.121 0.080
表2 两亚组间一般临床资料比较(±s)
Table 2 Comparison of general clinical data between two subgroups(±s)
组别 例数 年龄(岁) 孕龄(周) 晚孕期体质量(kg)
MPE亚组 18 29.3±4.0 37.4±3.5 87.6±9.3
SPE亚组 22 29.1±4.2 36.1±2.3 85.7±8.9
t值 ? 0.15 1.41 0.65
P值 ? 0.87 0.16 0.51
表3 各组血清FABP4及血脂水平比较(mmol/L，±s)
Table 3 Comparison of levels of serum FABP4 and blood fat between two groups(mmol/L，±s)
组别 例数 FABP4(ng/mL) TC TG HDL LDL
SPE亚组 22 167.81±5.43 6.44±0.08 3.62±0.12 1.70±0.07 3.12±0.03
MPE亚组 18 166.66±5.64 6.39±0.10 3.59±0.21 1.75±0.08 3.09±0.04
对照组 40 89.35±4.57 5.58±0.15 2.73±0.09 2.11±0.08 2.27±0.06
F值 ? 2 369.40 455.77 432.67 252.71 2 890.81
P值 ? 0.00 0.00 0.00 0.00 0.00
[1]
Ramsay JE，Jamieson N，Greer IA，et al.Paradoxical elevafion in adiponectin concentrations in women with preeclampsia[J]．Hypertension，2003，42(5)：891–894.
[2]
熊俊．脂代谢影响因素与妊娠期高血压疾病相关性研究进展[J]．实用妇产科杂志，2014，30(4)：256–257.
[3]
Scioscia M，Gumaa K，Rademacher TW.The link between insulin resistance and preeclampsia：new perspectives[J]．J Reprod Immunol，2009，82(2)：100–105.
[4]
谢幸，苟文丽，主编．妇产科学.8版[M]．北京：人民卫生出版社，2013：66–67.
[5]
Xu A，Wang Y，Xu JY，et al.Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome[J]．Clin Chem，2006，52(3)：405–413.
[6]
Boord JB，Maeda K，Makowski L，et al. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism，arteriosclerosis，and survival in apolipoprotein E-deficient mice[J]．Circulation，2004，110(11)：1492–1498.
[7]
Cabré A，Lázaro I，Girona J，et al. Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients [J]．Atherosclerosis，2007，195(1)：e150–e158.
[8]
Cabré A，Lázaro I，Girona J，et al. Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes[J]. J Lipid Res，2008，49(8)：1746–1751.
[9]
Rhee EJ，Lee WY，Park CY，et al. The association of serum adipocyte fatty acid-binding protein with coronary artery disease in Korean adults[J]. Eur J Endocrinol，2009，160(2)：165–172.
[10]
Fasshauer M，Seeger J，Waldeyer T，et al. Serum levels of the adipokine adipocyte fatty acid-binding protein are increased in preeclampsia[J]．Am J Hypertens，2008，2l(5)：582–586.
[11]
颜建英，张东妹．子痫前期患者血清脂联素表达水平与血脂代射及胰岛素抵抗的相关性[J]．国际妇产科学杂志，2012，39(1)：88–106.
[12]
Sahu S，Abraham R，Vedavalli R，et al.Study of lipid profile，lipid peroxidation and vitamin E in pregnancy induced hypertension[J]. Indian J Physiol Pharmacol，2009，53(4)：365–369.
[13]
周建军，胡娅莉，王志群，等．妊娠中期母体血脂及尿酸水平对子痫前期、妊娠期糖尿病和巨大儿的预测价值[J]．中华围产医学杂志，2012，15(4)：217–221.
[14]
Shangguan X，Liu F，Wang H，et al.Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia[J]．Clin Chim Acta，2009，407(1-2)：58–61.
[15]
郭海香，唐迎泉，陶春梅，等．载脂蛋白E基因多态性与子痫前期的相关性[J/CD]．中华妇幼临床医学杂志：电子版，2012，8(3)：304–307.
[16]
颜建英，王晓娟．孕妇血清及新生儿脐血、胎盘组织中脂肪性脂肪酸结合蛋白表达与子痫前期发病的关系[J]．中华妇产科杂志，2010，45(12)：885–890.
[17]
孙萍，荆玉慧，李健，等．子痫前期患者血清脂联素与血脂因子水平的测定及意义[J/CD]．中华妇幼临床医学杂志：电子版，2012，8(1)：15–17.
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