Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2025, Vol. 21 ›› Issue (02): 145 -150. doi: 10.3877/cma.j.issn.1673-5250.2025.02.004

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Expression of lncRNA and related miRNA in hypoxic-ischemic brain damage

Limin Wang1, Xiaojian Zhou1,()   

  1. 1. Department of Pediatrics,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201600,China
  • Received:2024-07-22 Revised:2025-01-09 Published:2025-04-01
  • Corresponding author: Xiaojian Zhou

Long non-coding RNAs (LncRNA)are highly conserved non-coding RNA(ncRNA).LncRNA can participate in hypoxic-ischemic brain damage (HIBD)by regulating the expression of microRNA (miRNA).Current research results show that lncRNA are especially abundant in the central nervous system,which can participate in various pathophysiological processes of diseases of the nervous system through regulating nerve regeneration,cerebrovascular generation,inhibiting apoptosis and inflammation,alleviating brain edema,and so on,and have a protective effect on neurons.This paper aims to review the latest research progress of lncRNA and its related miRNA in HIBD,explore the expression changes of lncRNA and its specific miRNA in HIBD,so as to provide new diagnose,treatment ideas and methods for the early diagnosis and treatment of HIBD.

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