Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (03): 266 -270. doi: 10.3877/cma.j.issn.1673-5250.2024.03.004

Special Column of Reproductive Medicine

Current research status on roles of microRNA on endometrial receptivity

Yi Wei1, Yuxi Zhou1, Ye Yang1, Xiufeng Ling1, Chun Zhao1,()   

  1. 1. Reproductive Medicine Center, Women′s Hospital of Nanjing Medical University (Nanjing Women and Children′s Healthcare Hospital), Nanjing 210004, Jiangsu Province, China
  • Received:2023-09-30 Revised:2024-04-15 Published:2024-06-01
  • Corresponding author: Chun Zhao
  • Supported by:
    National Natural Science Foundation of China(81971386)

Endometrial receptivity (ER) is a comprehensive state in which endometrium can accept embryo, and it is also a key factor for embryo implantation. MicroRNA (miRNA), as a non-coding RNA, regulates mRNA and downstream protein at the post-transcriptional level. The expression of miRNA and target genes of patients with ER defects is different from that of healthy women, suggesting that miRNA plays a role in the regulation of ER. The authors intend to elucidate the latest research status of miRNA involvement in ER and endometrial signaling pathways affecting embryo implantation, and other related molecules affecting ER, so as to provide reference for assessing the potential of miRNA in evaluating ER.

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