| [1] |
Suo C, Dann E, Goh I, et al. Mapping the developing human immune system across organs[J]. Science, 2022, 376(6597): eabo0510. DOI: 10.1126/science.abo0510.
|
| [2] |
Klein SL, Flanagan KL. Sex differences in immune responses[J]. Nat Rev Immunol, 2016, 16(10): 626-638. DOI: 10.1038/nri.2016.90.
|
| [3] |
Tobi EW, Lumey LH, Talens RP, et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific[J]. Hum Mol Genet, 2009, 18(21): 4046-4053. DOI: 10.1093/hmg/ddp353.
|
| [4] |
Sinha A, Madden J, Ross-Degnan D, et al. Reduced risk of neonatal respiratory infections among breastfed girls but not boys[J]. Pediatrics, 2003, 112(4): e303. DOI: 10.1542/peds.112.4.e303.
|
| [5] |
Markle JG, Frank DN, Mortin-Toth S, et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity[J]. Science, 2013, 339(6123): 1084-1088. DOI: 10.1126/science.1233521.
|
| [6] |
Garcia-velasco JA. Introduction: immunology and assisted reproductive technology in the 21st century[J]. Fertil Steril, 2017, 107(6): 1267-1268. DOI: 10.1016/j.fertnstert.2017.04.017.
|
| [7] |
Espey LL. Ovulation as an inflammatory reaction--a hypothesis[J]. Biol Reprod, 1980, 22(1): 73-106. DOI: 10.1095/biolreprod22.1.73.
|
| [8] |
Hock DL, Huhn RD, Kemmann E. Leukocytosis in response to exogenous gonadotrophin stimulation[J]. Hum Reprod, 1997, 12(10): 2143-2146. DOI: 10.1093/humrep/12.10.2143.
|
| [9] |
Al-Alem L, Puttabyatappa M, Rosewell K, et al. Chemokine ligand 20: a signal for leukocyte recruitment during human ovulation？[J]. Endocrinology, 2015, 156(9): 3358-3369. DOI: 10.1210/en.2014-1874.
|
| [10] |
Zhao Y, Zhang C, Huang Y, et al. Up-regulated expression of WNT5a increases inflammation and oxidative stress via PI3K/AKT/NF-kappa B signaling in the granulosa cells of PCOS patients[J]. J Clin Endocrinol Metab, 2015, 100(1): 201-211. DOI: 10.1210/jc.2014-2419.
|
| [11] |
Qi X, Yun C, Sun L, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome[J]. Nat Med, 2019, 25(8): 1225-1233. DOI: 10.1038/s41591-019-0509-0.
|
| [12] |
Agostinis C, Mangogna A, Bossi F, et al. Uterine immunity and microbiota: a shifting paradigm[J]. Front Immunol, 2019, 10: 2387. DOI: 10.3389/fimmu.2019.02387.
|
| [13] |
Strunz B, Bister J, Jonsson H, et al. Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy[J]. Sci Immunol, 2021, 6(56): eabb7800. DOI: 10.1126/sciimmunol.abb7800.
|
| [14] |
Parvanov D, Ganeva R, Vidolova N, et al. Decreased number of p16-positive senescent cells in human endometrium as a marker of miscarriage[J]. J Assist Reprod Genet, 2021, 38(8): 2087-2095. DOI: 10.1007/s10815-021-02182-5.
|
| [15] |
Yang F, Zheng Q, Jin L. Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface[J]. Front Immunol, 2019, 10: 2317. DOI: 10.3389/fimmu.2019.02317.
|
| [16] |
Wang W, Sung N, Gilman-Sachs A, et al. T helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1/Th2/Th9/Th17/Th22/Tfh cells[J]. Front Immunol, 2020, 11: 2025. DOI: 10.3389/fimmu.2020.02025.
|
| [17] |
Mor G, Aldo P, Alvero AB. The unique immunological and microbial aspects of pregnancy[J]. Nat Rev Immunol, 2017, 17(8): 469-482. DOI: 10.1038/nri.2017.64.
|
| [18] |
Vento-Tormo R, Efremova M, Botting RA, et al. Single-cell reconstruction of the early maternal-fetal interface in humans[J]. Nature, 2018, 563(7731): 347-353. DOI: 10.1038/s41586-018-0698-6.
|
| [19] |
Lee SK, Kim CJ, Kim DJ. Immune cells in the female reproductive tract[J]. Immune Netw, 2015, 15(1): 16-26. DOI: 10.4110/in.2015.15.1.16.
|
| [20] |
Wira CR, Rodriguez-Garcia M, Patel MV. The role of sex hormones in immune protection of the female reproductive tract[J]. Nat Rev Immunol, 2015, 15(4): 217-230. DOI: 10.1038/nri3819.
|
| [21] |
|
| [22] |
Qi X, Yun C, Pang Y, et al. The impact of the gut microbiota on the reproductive and metabolic endocrine system[J]. Gut Microbes, 2021, 13(1): 1-21. DOI: 10.1080/19490976.2021.1894070.
|
| [23] |
Baker JM, Al-Nakkash L, Herbst-Kralovetz MM. Estrogen-gut microbiome axis: physiological and clinical implications[J]. Maturitas, 2017, 103: 45-53. DOI: 10.1016/j.maturitas.2017.06.025.
|
| [24] |
Menon R, Watson SE, Thomas LN, et al. Diet complexity and estrogen receptor beta status affect the composition of the murine intestinal microbiota[J]. Appl Environ Microbiol, 2013, 79(18): 5763-5773. DOI: 10.1128/AEM.01182-13.
|
| [25] |
Zheng Y, Yu J, Liang C, et al. Characterization on gut microbiome of PCOS rats and its further design by shifts in high-fat diet and dihydrotestosterone induction in PCOS rats[J]. Bioprocess Biosyst Eng, 2021, 44(5): 953-964. DOI: 10.1007/s00449-020-02320-w.
|
| [26] |
Insenser M, Murri M, Del CR, et al. Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity[J]. J Clin Endocrinol Metab, 2018, 103(7): 2552-2562. DOI: 10.1210/jc.2017-02799.
|
| [27] |
|
| [28] |
Huang N, Chen L, Lian Y, et al. Impact of thyroid autoimmunity on in vitro fertilization/intracytoplasmic sperm injection outcomes and fetal weight[J]. Front Endocrinol (Lausanne), 2021, 12: 698579. DOI: 10.3389/fendo.2021.698579.
|
| [29] |
Huang N, Liu D, Lian Y, et al. Immunological microenvironment alterations in follicles of patients with autoimmune thyroiditis[J]. Front Immunol, 2021, 12: 770852. DOI: 10.3389/fimmu.2021.770852.
|
| [30] |
Practice Committee of the American Society for Reproductive Medicine. Subclinical hypothyroidism in the infertile female population: a guideline[J]. Fertil Steril, 2015, 104(3): 545-553. DOI: 10.1016/j.fertnstert.2015.05.028. |
| [31] |
Wang H, Gao H, Chi H, et al. Effect of levothyroxine on miscarriage among women with normal thyroid function and thyroid autoimmunity undergoing in vitro fertilization and embryo transfer: a randomized clinical trial[J]. JAMA, 2017, 318(22): 2190-2198. DOI: 10.1001/jama.2017.18249.
|
| [32] |
Jayasena CN, Franks S. The management of patients with polycystic ovary syndrome[J]. Nat Rev Endocrinol, 2014, 10(10): 624-636. DOI: 10.1038/nrendo.2014.102.
|
| [33] |
Qu J, Li B, Qiu M, et al. Discovery of immune-related diagnostic biomarkers and construction of diagnostic model in varies polycystic ovary syndrome[J]. Arch Gynecol Obstet, 2022, 306(5): 1607-1615. DOI: 10.1007/s00404-022-06686-y.
|
| [34] |
Qi X, Yun C, Liao B, et al. The therapeutic effect of interleukin-22 in high androgen-induced polycystic ovary syndrome[J]. J Endocrinol, 2020, 245(2): 281-289. DOI: 10.1530/JOE-19-0589.
|
| [35] |
Qi X, Nie Q, Pang Y, et al. IL-22 and its interaction with amino acid and glycolipid metabolite in polycystic ovary syndrome (PCOS) patients[J]. Chin Med J (Engl), 2022, 135(10): 1258-1260. DOI: 10.1097/CM9.0000000000001915.
|
| [36] |
Qi X, Zhang B, Zhao Y, et al. Hyperhomocysteinemia promotes insulin resistance and adipose tissue inflammation in PCOS mice through modulating M2 macrophage polarization via estrogen suppression[J]. Endocrinology, 2017, 158(5): 1181-1193. DOI: 10.1210/en.2017-00039.
|
| [37] |
Lima P, Nivet AL, Wang Q, et al. Polycystic ovary syndrome: possible involvement of androgen-induced, chemerin-mediated ovarian recruitment of monocytes/macrophages[J]. Biol Reprod, 2018, 99(4): 838-852. DOI: 10.1093/biolre/ioy096.
|
| [38] |
Becher T, Palanisamy S, Kramer DJ, et al. Brown adipose tissue is associated with cardiometabolic health[J]. Nat Med, 2021, 27(1): 58-65. DOI: 10.1038/s41591-020-1126-7.
|
| [39] |
Yuan X, Hu T, Zhao H, et al. Brown adipose tissue transplantation ameliorates polycystic ovary syndrome[J]. Proc Natl Acad Sci U S A, 2016, 113(10): 2708-2713. DOI: 10.1073/pnas.1523236113.
|
| [40] |
|
| [41] |
Forges T, Monnier-Barbarino P, Faure GC, et al. Autoimmunity and antigenic targets in ovarian pathology[J]. Hum Reprod Update, 2004, 10(2): 163-175. DOI: 10.1093/humupd/dmh014.
|
| [42] |
Gao H, Gao L, Wang W. Advances in the cellular immunological pathogenesis and related treatment of primary ovarian insufficiency[J]. Am J Reprod Immunol, 2022, 88(5): e13622. DOI: 10.1111/aji.13622.
|
| [43] |
|
| [44] |
Kelkar RL, Meherji PK, Kadam SS, et al. Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure[J]. J Reprod Immunol, 2005, 66(1): 53-67. DOI: 10.1016/j.jri.2005.02.003.
|
| [45] |
Pires ES. Multiplicity of molecular and cellular targets in human ovarian autoimmunity: an update[J]. J Assist Reprod Genet, 2010, 27(9-10): 519-524. DOI: 10.1007/s10815-010-9440-5.
|
| [46] |
Wu J, Zhuo Y, Liu Y, et al. Association between premature ovarian insufficiency and gut microbiota[J]. BMC Pregnancy Childbirth, 2021, 21(1): 418. DOI: 10.1186/s12884-021-03855-w.
|
| [47] |
|
| [48] |
Gueuvoghlanian-Silva BY, Hernandes C, Correia RP, et al. Deep infiltrating endometriosis and activation and memory surface markers and cytokine expression in isolated Treg cells[J]. Reprod Sci, 2020, 27(2): 599-610.DOI: 10.1007/s43032-019-00060-1.
|
| [49] |
Matteo M, Cicinelli E, Neri M, et al. Pro-inflammatory M1/Th1 type immune network and increased expression of TSG －6 in the eutopic endometrium from women with endometriosis[J]. Eur J Obstet Gynecol Reprod Biol, 2017, 218: 99-105. DOI: 10.1016/j.ejogrb.2017.08.014.
|
| [50] |
Vallve-Juanico J, Houshdaran S, Giudice LC. The endometrial immune environment of women with endometriosis[J]. Hum Reprod Update, 2019, 25(5): 564-591. DOI: 10.1093/humupd/dmz018.
|
| [51] |
|
| [52] |
|
| [53] |
Clark DA, Ding JW, Chaouat G, et al. The emerging role of immunoregulation of fibrinogen-related procoagulant Fgl2 in the success or spontaneous abortion of early pregnancy in mice and humans[J] Am J Reprod Immunol, 1999, 42(1): 37-43. DOI: 10.1111/j.1600-0897.1999.tb00463.x.
|
| [54] |
Wang F, Jia W, Fan M, et al. Single-cell immune landscape of human recurrent miscarriage[J]. Genomics Proteomics Bioinformatics, 2021, 19(2): 208-222. DOI: 10.1016/j.gpb.2020.11.002.
|
| [55] |
|