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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (05): 497 -504. doi: 10.3877/cma.j.issn.1673-5250.2023.05.001

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Current research status of treatment of cervical cancer

Minrong Ma, Cong Li, Qin Zhou†()   

  1. Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
  • Received:2023-04-17 Revised:2023-09-08 Published:2023-10-01
  • Corresponding author: Qin Zhou
  • Supported by:
    National Natural Science Foundation of China for Youths(81100399)
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According to the 2022 Global Cancer Statistics Report, the incidence of uterine cervical neoplasms ranks first among third major gynecological malignancies in the world, it is the fourth most common type of gynecological cancer in women, and is also the fourth leading cause of malignancy related death in women in the United States. According to International Federation of Obstetrics and Gynecology (FIGO), patients with advanced or recurrent cervical cancer have a poor prognosis and are the leading cause of death from uterine cervical neoplasms. The classical treatments of cervical cancer include radiotherapy, chemotherapy and surgery, etc.. However, the effectiveness of these treatments may not be good to some patients, especially those patients with advanced or recurrent uterine cervical neoplasms. Recent research have found that viral gene integration, cellular oxidative stress, vascular endothelial growth factor (VEGF), epidermal growth factor (EGFR), programmed cell death receptor (PD)-1 and other related signaling pathways play an important role in uterine cervical neoplasms occurrence and development. A variety of novel and emerging therapeutic strategies based on these signaling pathways have been developed and applied clinically, bringing hope for treatment of more patients with advanced or recurrent uterine cervical neoplasms. In addition, there are still a lot of researches on uterine cervical neoplasms stem cells (CCSC), exosome microRNA (miR)-651 and other potential therapeutic targets of uterine cervical neoplasms is under way. The authors intend to review the latest research progresses of 5 new therapeutic schemes of neoadjuvant chemotherapy (NACT), drug targeted therapy, immunotherapy, therapeutic vaccine and photodynamic therapy (PDT), and their potential therapeutic targets for uterine cervical neoplasms.

Key words: Uterine neoplasms, Neoadjuvant therapy, Immunosuppressive agents, Vaccination, Molecular targeted therapy, Immunotherapy, active, Photochemotherapy, Female
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