Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (05): 505 -510. doi: 10.3877/cma.j.issn.1673-5250.2023.05.002

Forum

Genetic testing and precision molecular targeted therapy in diagnosis and treatment of epithelial ovarian caner

Changsheng Lin, Jun Zhan, Xue Xiao()   

  1. Department of Obstetrics and Gynecology, Reproductive Endocrine and Reproductive Medicine Regulation Research Laboratory, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2023-03-11 Revised:2023-08-30 Published:2023-10-01
  • Corresponding author: Xue Xiao
  • Supported by:
    National Natural Science Foundation of China(82071651)

Ovarian cancer is top 3 female reproductive system carcinoma in China. Among ovarian cancer, epithelial ovarian cancer (EOC) has the highest incidence. Due to the lack of specific early clinical symptoms of EOC patients, 70% of them were in the late clinical stage of Federation International of Gynecology and Obstetrics (FIGO) at the time of being diagnosed. The 5-year overall survival rate of patients with EOC was only 30%-40%. With development of gene detection technology, and development and clinical application of targeted drugs in recent years, the period of progression-free survival (PFS) of EOC patients is prolonged. The authors intend to review the latest research progresses in clinical application of gene mutation and targeted drug therapy in patients with EOC.

表1 2023年,AACR发布的位居美国前3位女性生殖系统恶性肿瘤新发病例及死亡病例数比较(例数)
表2 2022年,GLOBOCAN发布的位居中国前3位女性生殖系统恶性肿瘤新发病例及死亡病例数比较(例数)
表3 针对铂敏感复发性EOC患者采取PARP抑制剂(奥拉帕利、尼拉帕利、卢卡帕利)治疗的中位PFS期比较(月)
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