Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (05): 511 -516. doi: 10.3877/cma.j.issn.1673-5250.2023.05.003

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Advances in endometrial cancer-related biomarker research

Lu Wang, Yang Fan()   

  1. Third Clinical Medical College, Ningxia Medical University, Yinchuan 750016, Ningxia Hui Autonomous Region, China
    Department of Obstetrics and Gynecology, People′s Hospital of Ningxia Hui Autonomous Region, Yinchuan 750016, Ningxia Hui Autonomous Region, China
  • Received:2023-02-14 Revised:2023-07-01 Published:2023-10-01
  • Corresponding author: Yang Fan
  • Supported by:
    Project of Key Research & Development Planning of Department of Science and Technology in Ningxia Hui Autonomous Region(2022BEG01003)

Molecular genetic mechanisms are increasingly important in the clinical management of endometrial carcinoma (EC), and molecular typing can effectively predict prognosis and guide treatment. In 2013, it is the start of the US Cancer Genome Atlas project that kicked off the molecular management of EC. In 2020, the Classification of Tumours of the Female Reproductive System (5th edition) issued by the World Health Organization (WHO) integrates molecular genetic features into the pathomorphological typing of EC. In 2021, for the first time in China, molecular staging of endometrial cancer was included in the guidelines. At the same time, researches on biomarkers based on molecular typing is ongoing, and many new biomarkers are being discovered. However, there are currently no routinely applied molecular markers for EC diagnosis and treatment, and the current methods of EC staging are multiple and not yet uniform. We intend to describe the latest status of researches on genes, proteins and hormone-related molecular biomarkers in EC patients, with the aim of providing a reference for relevant research in this field.

[1]
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2021, 71(3): 209-249. DOI: 10.3322/caac.21660.
[2]
Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023[J]. CA Cancer J Clin, 202373(1):17-48. DOI: 10.3322/caac.21763.
[3]
Zheng RS, Zhang SW, Sun KX, et al. Cancer statistics in China, 2016 [J]. Chin J Oncol, 2023, 45(3): 212-220. DOI: 10.3760/cma.j.cn112152-20220922-00647.
[4]
中国抗癌协会妇科肿瘤专业委员会,中华医学会病理学分会,国家病理质控中心.子宫内膜癌分子检测中国专家共识(2021)[J].中国癌症杂志2021, 31(11): 1126-1144. DOI: 10.19401/j.cnki.1007-3639.2021.11.012.
[5]
Stelloo E, Nout RA, Osse EM, et al. Improved risk assessment by integrating molecular and clinicopathological factors in early-stage endometrial cancer-combined analysis of the portec cohorts [J]. Clin Cancer Res, 2016, 22(16): 4215-4224. DOI: 10.1158/1078-0432.CCR-15-2878.
[6]
Kommoss S, McConechy MK, Kommoss F, et al. Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series [J]. Ann Oncol, 2018, 29(5): 1180-1188. DOI: 10.1093/annonc/mdy058.
[7]
Concin N, Matias-Guiu X, Vergote I, et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma [J]. Int J Gynecol Cancer, 2021, 31(1): 12-39. DOI: 10.1136/ijgc-2020-002230.
[8]
Raffone A, Travaglino A, Saccone G, et al. PTEN expression in endometrial hyperplasia and risk of cancer: a systematic review and Meta-analysis [J]. Arch Gynecol Obstet, 2019, 299(6): 1511-1524. DOI: 10.1007/s00404-019-05123-x.
[9]
刘帅,杨曦,张乃怿,等.检测PTEN、PI3KCA、Ki67在子宫内膜细胞学筛查子宫内膜癌中的价值[J].中国妇产科临床杂志2023, 24(1): 29-32. DOI: 10.13390/j.issn.1672-1861.2023.01.009.
[10]
Nakamura M, Obata T, Daikoku T, et al. The association and significance of p53 in gynecologic cancers: the potential of targeted therapy [J]. Int J Mol Sci, 2019, 20(21): 5482. DOI: 10.3390/ijms20215482.
[11]
Köbel M, Ronnett BM, Singh N, et al. Interpretation of P53 immunohistochemistry in endometrial carcinomas: toward increased reproducibility [J]. Int J Gynecol Pathol, 2019, 38 Suppl 1(Iss 1 Suppl 1): S123-S131. DOI: 10.1097/PGP.0000000000000488.
[12]
Kandoth C, Schultz N, Cherniack AD, et al. Integrated genomic characterization of endometrial carcinoma[J]. Nature2013497(7447):67-73. DOI: 10.1038/nature12113.
[13]
Lu J, Liang J, Xu M, Wu Z, et al. Identification of an eleven-miRNA signature to predict the prognosis of endometrial cancer [J]. Bioengineered, 2021, 12(1): 4201-4216. DOI: 10.1080/21655979.2021.1952051.
[14]
Donkers H, Hirschfeld M, Wei D, et al. Usefulness of microRNA detection in the diagnostics of endometrial cancer [J]. Acta Obstet Gynecol Scand, 2021, 100(6): 1148-1154. DOI: 10.1111/aogs.14141.
[15]
Lu Y, Tang W, Wang X, et al. Development of potential prognostic biomarkers based on DNA methylation-driven genes for patients with endometrial cancer [J]. Int J Gen Med, 2021, 14: 10541-10555. DOI: 10.2147/IJGM.S341771.
[16]
Huo X, Sun H, Cao D, et al. Identification of prognosis markers for endometrial cancer by integrated analysis of DNA methylation and RNA-Seq data [J]. Sci Rep, 2019, 9(1): 9924. DOI: 10.1038/s41598-019-46195-8.
[17]
Grassi T, Harris FR, Smadbeck JB, et al. Personalized tumor-specific DNA junctions to detect circulating tumor in patients with endometrial cancer [J]. PLoS One, 2021, 16(6): e0252390. DOI: 10.1371/journal.pone.0252390.
[18]
Susini T, Baldi F, Howard CM, et al. Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer [J]. J Clin Oncol, 1998, 16(3): 1085-1093. DOI: 10.1200/JCO.1998.16.3.1085.
[19]
Mori M, Mori T, Yamamoto A, et al. Proliferation of poorly differentiated endometrial cancer cells through autocrine activation of FGF receptor and HES1 expression [J]. Hum Cell, 2019, 32(3): 367-378. DOI: 10.1007/s13577-019-00249-1.
[20]
Li BL, Lu W, Qu JJ, et al. Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis [J]. J Cell Physiol, 2019, 234(3): 2943-2953. DOI: 10.1002/jcp.27111.
[21]
Sootome H, Fujita H, Ito K, et al. Futibatinib is a novel irreversible FGFR 1-4 inhibitor that shows selective antitumor activity against FGFR-deregulated tumors [J]. Cancer Res, 2020, 80(22): 4986-4997. DOI: 10.1158/0008-5472.CAN-19-2568.
[22]
Ocak B, Atalay Sahin AB, et al. The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer [J]. Bosn J Basic Med Sci, 2021, 21(5): 549-554. DOI: 10.17305/bjbms.2020.5437.
[23]
He X, Lei S, Zhang Q, et al. Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: analysis of the cancer genome atlas data [J]. Oncol Lett, 2020, 19(3): 1906-1914. DOI: 10.3892/ol.2020.11295.
[24]
Toumpeki C, Liberis A, Tsirkas I, et al. The role of arid1a in endometrial cancer and the molecular pathways associated with pathogenesis and cancer progression [J]. In Vivo, 2019, 33(3): 659-667. DOI: 10.21873/invivo.11524.
[25]
Brunner A, Riss P, Heinze G, et al. pHH3 and survivin are co-expressed in high-risk endometrial cancer and are prognostic relevant [J]. Br J Cancer, 2012, 107(1): 84-90. DOI:10.1038/bjc.2012.198.
[26]
Flindris S, Katsoulas N, Goussia A, et al. The expression of NRIP1 and LCOR in endometrioid endometrial cancer [J]. In Vivo, 2021, 35(5): 2631-2640. DOI: 10.21873/invivo.12545.
[27]
Degez M, Caillon H, Chauviré-Drouard A, et al. Endometrial cancer: a systematic review of HE4, REM and REM-B [J]. Clin Chim Acta, 2021, 515: 27-36. DOI: 10.1016/j.cca.2020.12.029.
[28]
Yoriki K, Mori T, Kokabu T, et al. Estrogen-related receptor alpha induces epithelial-mesenchymal transition through cancer-stromal interactions in endometrial cancer [J]. Sci Rep, 2019, 9(1): 6697. DOI: 10.1038/s41598-019-43261-z.
[29]
van Weelden WJ, van der Putten LJM, Inda MA, et al. Oestrogen receptor pathway activity is associated with outcome in endometrial cancer [J]. Br J Cancer, 2020, 123(5): 785-792. DOI: 10.1038/s41416-020-0925-4.
[30]
Wang C, Tran DA, Fu MZ, et al. Estrogen receptor, progesterone receptor, and HER2 receptor markers in endometrial cancer [J]. J Cancer, 2020, 11(7): 1693-1701. DOI: 10.7150/jca.41943.
[31]
迟言邦,王琎,孙静莉. 短发夹RNA介导调节S100A4表达对子宫内膜癌KLE细胞增殖和凋亡的影响[J]. 发育医学电子杂志2021, 9(1): 32-37. DOI: 10.3969/j.issn.2095-5340.2021.01.006.
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