Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (05): 511 -516. doi: 10.3877/cma.j.issn.1673-5250.2023.05.003

Forum

Advances in endometrial cancer-related biomarker research

Lu Wang, Yang Fan()   

  1. Third Clinical Medical College, Ningxia Medical University, Yinchuan 750016, Ningxia Hui Autonomous Region, China
    Department of Obstetrics and Gynecology, People′s Hospital of Ningxia Hui Autonomous Region, Yinchuan 750016, Ningxia Hui Autonomous Region, China
  • Received:2023-02-14 Revised:2023-07-01 Published:2023-10-01
  • Corresponding author: Yang Fan
  • Supported by:
    Project of Key Research & Development Planning of Department of Science and Technology in Ningxia Hui Autonomous Region(2022BEG01003)

Molecular genetic mechanisms are increasingly important in the clinical management of endometrial carcinoma (EC), and molecular typing can effectively predict prognosis and guide treatment. In 2013, it is the start of the US Cancer Genome Atlas project that kicked off the molecular management of EC. In 2020, the Classification of Tumours of the Female Reproductive System (5th edition) issued by the World Health Organization (WHO) integrates molecular genetic features into the pathomorphological typing of EC. In 2021, for the first time in China, molecular staging of endometrial cancer was included in the guidelines. At the same time, researches on biomarkers based on molecular typing is ongoing, and many new biomarkers are being discovered. However, there are currently no routinely applied molecular markers for EC diagnosis and treatment, and the current methods of EC staging are multiple and not yet uniform. We intend to describe the latest status of researches on genes, proteins and hormone-related molecular biomarkers in EC patients, with the aim of providing a reference for relevant research in this field.

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