Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2025, Vol. 21 ›› Issue (02): 140 -144. doi: 10.3877/cma.j.issn.1673-5250.2025.02.003

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Current research status on window of implantation and endometrial microbiota in personalized embryo transfer

Shawei Sa1, Qianhong Ma1,()   

  1. 1. Department of Obstetrics and Gynecology,Key Laboratory of Birth Defects and Related Disseases of Women and Children (Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China
  • Received:2024-12-01 Revised:2025-03-20 Published:2025-04-01
  • Corresponding author: Qianhong Ma

In assisted reproductive technology (ART),the window of implantation(WOI)and endometrial microbiome are crucial for the successful implantation of embryos and pregnancy.WOI refers to endometrial receptivity(ER),which allows the best time for embryo implantation and subsequent pregnancy.Impairments in WOI and microbial imbalances can reduce the success rate of ART and increase the risk of recurrent implantation failures(RIF)and adverse pregnancy outcomes.Although various methods exist to assess endometrial WOI and microenvironment by endometrial microbiological testing (EMT),they face numerous limitations and challenges in clinical application.With the advent of personalized embryo transfer (p ET)strategies,there is an increasing demand for precise understanding and manipulation of the WOIand endometrial microbiome.This review explores recent advancements in study of WOI and endometrial microbiome within context of p ET,aiming to enhance success rate of ART and provide a theoretical foundation and practical guidance for future research directions of ART.

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