Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (04): 374 -381. doi: 10.3877/cma.j.issn.1673-5250.2024.04.003

Special Column of Perinatal Medicin

Current research status on etiology of genetic factors in recurrent spontaneous miscarriage

Min Wang1, Ling Zhou1,()   

  1. 1.Department of Obstetrics and Gynecology,the Ninth Medical Center of PLA General Hospital,Beijing 100101,China
  • Received:2024-02-01 Revised:2024-06-21 Published:2024-08-01
  • Corresponding author: Ling Zhou

In recent years,the incidence of recurrent spontaneous abortion(RSA)has shown an increasing trend,and has become an important issue in the field of reproductive health.The etiology of RSA in women of childbearing age is very complex,and with the development of medical genetics and reproductive genetics,people have gained more in-depth understanding of etiology of genetics factors associated with RSA.This review elaborates on progress of research on genetics factors of RSA,including chromosome abnormalities in couples,chromosomal abnormalities in embryos and genetic variants,and discusses the future direction of genetic testing for RSA and ethical issues that may be involved,with the aim of providing references for clinical diagnosis and treatment of genetic factors underlying etiology of RSA.

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