Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (05): 612 -616. doi: 10.3877/cma.j.issn.1673-5250.2018.05.020

Special Issue:

Review

Research progress of methods on the assessment of embryonic quality

Menghui Geng1, Can Zhang1, Aying Xing1, Dalin Wang2, Yanqiu Hu3,()   

  1. 1. Department of Obstetrics and Gynecology, Dalian Medical University, Dalian 116044, Liaoning Province, China
    2. Department of Obstetrics and Gynecology, Medical College of Yangzhou University, Yangzhou 225000, Jiangsu Province, China
    3. Reproductive Medical Centre, Northern Jiangsu People’s Hospital, Yangzhou 225000, Jiangsu Province, China
  • Received:2018-02-27 Revised:2018-07-09 Published:2018-10-01
  • Corresponding author: Yanqiu Hu
  • About author:
    Corresponding author: Hu Yanqiu, Email:
  • Supported by:
    Project of Jiangsu Provincial Commission of Health and Family Planning for Youth Medicine Key Talents(QNRC2016347)

Selection of embryos with higher potentiality of development has been one of the major challenges in assisted reproductive technology (ART). Morphological scoring method is a general method to evaluate embryonic quality, but it′s not an accurate method due to the personal error. In the past decade, with the development of metabolomics and proteomics, metabolities in embryo culture media such as pyruvate, amino acids, human leukocyte antigen (HLA)-G can be precisely analyzed by newly developed technologies such as Fourier transformation infrared (FTIR) spectroscopy, near infrared spectroscopy (NIR), 1H-proton nuclear magnetic resonance (1H-NMR) spectroscopy, and Raman spectroscopy. Studies have shown that the metabolic profiles vary between pregnancy and non-pregnancy embryos. Thus, noninvasive metabolomics and proteomics might be applied to guide clinical protocol adjustments of in vitro fertilization (IVF) and select transplanted embryo with the best quality. However, chromosome abnormalities in embryo can not be detected by morphological scoring method, metabolomics, proteomics, and genomics can make up for this deficiency. Genomic screening could be conducted to detect non-euploidy embryo before transplantation and thus improve the success rate of ART. This paper reviews the latest research progress of the embryo quality assessment methods.

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