Current research status of susceptibility genes and epigenetics on childhood asthma

doi:10.3877/cma.j.issn.1673-5250.2023.03.001

Asthma is the most common chronic respiratory diseases in children, characterized by repeated cough, shortness of breath, wheezing, etc., which seriously affects children′s health, daily life and learning, and brings heavy disease and economic burden to families and society. With the advancement of genome-wide association studies (GWAS), great progresses have been made at the genetic level, and its pathogenesis has been better elaborated in asthma susceptibility genes and epigenetics, providing guidance for gene diagnosis and targeted therapy. The author intends to elaborate on the global incidence of childhood asthma, the latest research status of molecular phenotypes, susceptibility genes, and epigenetic modifications in children with asthma.

Key words: Asthma, Genetic testing, Genetic predisposition to disease, Epigenomics, Genome-wide association study, Molecular targeted therapy, Immunophenotyping, Child health

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