Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (05): 504 -510. doi: 10.3877/cma.j.issn.1673-5250.2024.05.005

Special Column of Frontiers in Obstetrics

Current research status of omics analysis in the molecular mechanism of preterm birth

Yiming Fei1, Zhuo Liu1, Lijuan Zhang,1   

  1. 1.Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang 110122,Liaoning Province,China
  • Received:2024-05-30 Revised:2024-09-01 Published:2024-10-01
  • Corresponding author: Lijuan Zhang

Those who give birth with a gestational age of 28-36+6 weeks of gestation are defined as preterm birth.The incidence of preterm birth in countries around the world is 4%-16%,and about 7%in China.Premature infants are prone to serious complications such as neonatal intracranial hemorrhage and neonatal respiratory d istress syndrome.However,the mechanism of preterm birth has not been clinically elucidated,and there is no particularly effective method for prediction and prevention.More and more scholars are using omics to study the mechanism of preterm birth,including genomics,microbiomics,transcriptomics,proteomics,metabolomics,etc.,and have discovered many potential related genes,mechanisms of action and maternal biomarkers,such as CPPED1 gene,Wnt signaling pathway and fetal fibronectin (f FN).The authors intend to focus on the latest research status of omics research related to the molecular mechanism of preterm birth,including genomics,microbiomics,transcriptomics,proteomics,metabolomics,etc.,aiming to provide a theoretical reference for the clinical prediction and diagnosis and treatment of preterm birth.

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