Changes in size of uterine myoma during pregnancy and its association with adverse pregnancy outcomes

doi:10.3877/cma.j.issn.1673-5250.2023.05.016

Uterine myoma (UM) is the most common benign tumor of the female genital tract, which often occurs in their reproductive age, the cause has not been clarified so far, and its occurrence and development may be related to estrogen and progesterone. Although the levels of estrogen and progesterone produced in the placenta during pregnancy increases with the increase of gestational age, but the volume of UM does not increase with the increase of estrogen and progesterone levels. Other endocrine hormones produced by the body during pregnancy, and amniotic cavity tension, uterine contraction and other factors also affect the blood supply and growth mode of uterine myoma. Pregnancy complicated with UM is a high risk factor for some adverse pregnancy outcomes, such as premature delivery, placental abruption, postpartum hemorrhage etc., and also increases the rate of cesarean delivery. Therefore, this article combines relevant literature at domestic and abroad to analyze the changes of UM during pregnancy and their association with adverse pregnancy outcomes, to improve the clinical understanding of pregnancy with UM and to provide ideas for clinical correct management of pregnancy with UM.

Key words: Pregnancy, Leiomyoma, Pregnancy outcome, Premature birth, Cesarean section, Postpartum hemorrhage, Pregnant women

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