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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2022, Vol. 18 ›› Issue (05): 517 -522. doi: 10.3877/cma.j.issn.1673-5250.2022.05.004

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Research progress on probiotics in clinical application of neonatal respiratory diseases

Jinli Yan, Dapeng Chen†()   

  1. Department of Neonatology, Key Laboratory of Birth Defects and Related Disseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2022-03-27 Revised:2022-08-31 Published:2022-10-01
  • Corresponding author: Dapeng Chen
  • Supported by:
    National Key Research and Development Program(2017YFC0109004)
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Neonatal respiratory system disease is a common disease of newborns and a common cause of neonatal death. Probiotics are a kind of active microorganisms beneficial to the host by colonizing the human body and changing the composition of a certain part of the host. In recent years, researches on the relationship between probiotics and neonatal respiratory diseases have become a hot topic in this field. Probiotics can enhance the intestinal immune function and improve the systemic immunity of newborns, so as to suppress the pathological and pathophysiological functions of respiratory diseases and achieve purpose of treating these diseases. The author reviews the research progress on the definition and types of probiotics, safety, adverse effects and therapeutic mechanism of clinical application of probiotics in neonates, and probiotics in treatment of neonatal respiratory diseases, so as to enable pediatricians to better understand the role of probiotics in treatment ofsuch diseases.

Key words: Probiotics, Enteropulmonary axis, Pneumonia, ventilator-associated, Bronchopulmonary dysplasia, Meconium aspiration syndrome, Asthma, Infant, newborn
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