Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2022, Vol. 18 ›› Issue (06): 640 -644. doi: 10.3877/cma.j.issn.1673-5250.2022.06.004

Forum

Current research status in treatment of preterm infants with bronchopulmonary dysplasia by human amniotic epithelial stem cells

Bing Yuan, Kai Yan()   

  1. Department of Pediatrics, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
  • Received:2022-05-06 Revised:2022-10-09 Published:2022-12-01
  • Corresponding author: Kai Yan
  • Supported by:
    Science and Technology Plan Project by Health Committee of Jiangxi Province(SKJP220212361)

With advancement of perinatal medicine, the survival rate of preterm infants, especially very preterm infants and extremely preterm infants have been increased greatly, but the consequent bronchopulmonary dysplasia (BPD) has become an increasingly urgent clinical problems. In recent years, many experimental and clinical studies have found that stem cells can be used in treatment of preterm infants with BPD to repair damaged tissues by reducing their inflammation and pulmonary fibrosis, anti-oxidative stress damage, human amniotic epithelial stem cell (hAESC) especially have significant advantages such as self-renewing, multi-directional differentiation potential, without tumorigenicity, low immunogenicity, without medical ethics disputes, strong paracrine property and immunoloregulation function, and have the effect of improving human cardiopulmonary function, which has become a research hotspot in the treatment of preterm infant with BPD. The author intends to elaborate on current research status of mechanism of action, advantages and challenges of hAESC for treatment of preterm infant with BPD.

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