Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (03): 251 -259. doi: 10.3877/cma.j.issn.1673-5250.2024.03.002

Special Column of Reproductive Medicine

Correlation between HLA gene and IL gene polymorphisms with recurrent spontaneous abortion

Shaohua Zhang1, Aiqi Lin2, Yu Zhang3, Xiaoyun Dong4, Hongying Liu4,()   

  1. 1. Naval Medical University of PLA, Changhai Hospital, Shanghai 200433, China
    2. CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, Shandong Province, China
    3. Department of Pediatrics, Zibo Central Hospital, Zibo 255000, Shandong Province, China
    4. Department of Genetics, College of Biological Science and Technology, Weifang Medical College, Weifang 261053, Shandong Province, China
  • Received:2023-12-23 Revised:2024-03-09 Published:2024-06-01
  • Corresponding author: Hongying Liu
  • Supported by:
    Natural Science Foundation of Department of Science and Technology of Shandong Province(ZR2019BC095)

Recurrent spontaneous abortion (RSA) refers to a polygenic genetic disease affected by multiple pairs of genes and environmental factors, in which genetic factors, immune abnormalities, endocrine dysfunction, reproductive system anatomical structure abnormalities and microbial infections of childbearing age women can contribute to RSA. The polymorphisms of human leukocyte antigen (HLA) family genes and interleukin (IL) family genes play important roles in maternal-fetal interface immunity. Mutations of HLA and IL genes can cause abnormal immune function in women of childbearing age, as the main factors leading to RSA. This article reviews the latest research progress of correlation between HLA and IL gene polymorphisms with RSA.

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