Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (01): 16 -22. doi: 10.3877/cma.j.issn.1673-5250.2023.01.003

Editorial

Current status and outlook of research in treatment of unexplained recurrent spontaneous abortion

Ouchan Hu, Zhongying Huang()   

  1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2022-09-30 Revised:2023-01-05 Published:2023-02-01
  • Corresponding author: Zhongying Huang
  • Supported by:
    National Natural Science Foundation of China(81200453); Major Demonstration and Application Project of Chengdu Science and Technology Bureau(2019-YF09-00210-SN)

Recurrent spontaneous abortion (RSA) is typically defined as two or more consecutive spontaneous miscarriage with global incidence of 1%-5%. Among them, about 50% cases were with unknown causes, namely unexplained recurrent spontaneous abortion (URSA). Studies showed that URSA may be related to the maternal-fetal immune imbalance while the exact etiology and pathogenesis underlying URSA remains unclear. At present, it is still lack of recognized effective treatments for URSA. Various treatments such as lymphocyte immunotherapy (LIT), intravenous immunoglobulin (IVIG), immunosuppressant, immunomodulator, progesterone and anticoagulant therapy have been tried in URSA women although efficacy and safety of certain treatments are controversial. Here we summarize current status and advances in research on diagnosis and treatments of URSA, especially treatments such as LIT, IVIG, immunosuppressant, granulocyte colony-stimulating factor (G-CSF), intralipid, progesterone, anticoagulant, vitamin D, herbal medicine and preimplantation genetic testing for aneuploidies (PGT-A), aiming to provide a reference for doctors on choosing strategies for URSA patients.

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