To explore the survival rate and its trend of malignant tumor in childbearing-aged female (MTCF) with 15-49 years old in Qidong, Jiangsu Province in the past 45 years.

A total of 10 014 patients with MTCF (including benign tumors of brain and central nervous system) aged 15-49 years registered in the Qidong Cancer Registry System and All-Cause Mortality Registration System which affiliated to Qidong Liver Cancer Institute from January 1, 1972 to December 31, 2016 were selected in the study. The 1-, 5-, and 10-year observed survival rate (OSR) and relative survival rate (RSR) of MTCF patients were calculated by SURV 3.01 software, and Hakulinen likelihood ratio test was applied for comparison of RSR of MTCF patients in nine periods (1972-1976, 1977-1981, 1982-1986, 1987-1991, 1992-1996, 1997-2001, 2002-2006, 2007-2011, 2012-2016, every 5-year interval, ranging from the 1st to the 9th 5-year) and seven age groups (15-19, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49 years, every 5-year interval, ranging from the 1st to the 7th 5-year) in the past 45 years. average annual percentage change (AAPC) of 1-, 5-, and 10-year OSR and RSR of MTCF patients were analyzed. The procedures followed in this study were in accordance with the regulations of the Ethics Committee of Qidong People′s Hospital and were reviewed and approved by this Ethics Committee (Approval No. ER-XXM-LWTG-2021-051).

①From 1972-2016, the 1-, 5-, and 10-year OSR of MTCF patients in Qidong were 53.23%, 36.54%, and 32.54%, respectively, and the 1-, 5-, and 10-year RSR were 53.34%, 36.98%, and 33.45%, respectively. The 1- and 5-year RSR increased from 44.04% and 25.06% in the 1st 5-year interval to 83.24% and 68.04% in the 9th 5-year interval, and 10-year RSR increased from 21.14% in the 1st 5-year interval to 47.24% in the 8th 5-year interval. The differences were statistically significant among the 1-, 5-, and 10-year RSR of MTCF patients in nine periods (χ² =1 291.19, P<0.001). The AAPC of 1-, 5-, and 10-year OSR of MTCF patients in Qidong were 2.18%, 3.30%, and 3.66%, respectively, and AAPC of 1-, 5-, and 10-year RSR were 2.18%, 3.28%, and 3.61%, respectively, and the upward trend of 1-, 5-, and 10-year OSR and RSR of MTCF patients in nine periods all were statistically significant (1-, 5-, and 10-year OSR: t=5.62, P=0.001; t=6.47, P<0.001; t=6.45, P<0.001; 1-, 5-, and 10-year RSR: t=5.63, P=0.001; t=6.50, P<0.001; t=6.48, P<0.001). ②The 5-year RSR of MTCF patients in the 1st to 7th 5-year intervals of Qidong within 45 years were 27.47%, 32.29%, 33.21%, 34.76%, 34.87%, 36.00%, and 40.60%, respectively. When comparing the overall 5-year RSR among these seven age groups, there was a statistically significant difference (χ²=90.66, P<0.001). The AAPC of 5-year RSR of patients in the 1st to 7th 5-year intervals were 3.56%, 2.48%, 3.47%, 3.18%, 3.02%, 3.54%, and 3.32%, respectively, and the 5-year RSR patients in these seven age groups showed a statistically significant upward trend in nine periods (t=5.03, P=0.002; t=6.34, P<0.001; t=10.80, P<0.001; t=5.24, P=0.001; t=5.66, P=0.001; t=5.09, P=0.001; t=6.66, P<0.001). ③Among the top 10 MTCF patients in terms of incidence in Qidong, the highest 5-year RSR was for thyroid cancer (97.05%), while the lowest was for liver cancer (6.86%).

The overall survival rate of MTCF patients in Qidong in the past 45 years has shown an upward trend. It is important to continue focusing on the health of women of childbearing age and strengthen screening strategies for key cancers such as liver cancer. Early detection, diagnosis, and treatment are crucial in order to further improve the overall survival rate of MTCF patients.