Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (04): 382 -388. doi: 10.3877/cma.j.issn.1673-5250.2019.04.005

Special Issue:

Original Article

Correlation between serum complement C1q tumor necrosis factor related protein 3, cyclophilin A and abnormal metabolism of lipid in patients with preeclampsia

Qiaolian Zhou1,(), Qin Li1   

  1. 1. Department of Obstetrics, Qinghai University Affiliated Hospital, Xining 810001, Qinghai Province, China
  • Received:2019-02-26 Revised:2019-07-12 Published:2019-08-01
  • Corresponding author: Qiaolian Zhou
  • About author:
    Corresponding author: Zhou Qiaolian, Email:
  • Supported by:
    General Guiding Project of Health and Family Planning Commission of Qinghai Province(2018-wjzdx-117)
Objective

To investigate the correlation between serum complement C1q tumor necrosis factor related protein (CTRP)-3, cyclophilin A (CyPA) and abnormal metabolism of lipid in patients with preeclampsia (PE).

Methods

A total of 98 cases of PE patients who admitted to Department of Obstetrics, Qinghai University Affiliated Hospital from January 2017 to June 2018 were selected as study subjects. According to the severity of PE, they were divided into severe PE group (n=48) and mild PE group (n=50). At the same time, another 50 cases of healthy pregnant women who received regular prenatal examination in our hospital during the same period were included in the control group. The serum levels of CTRP-3 and CyPA of three groups were measured by enzyme linked immunosorbent assay. The serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of three groups were measured by automatic biochemical analyzer. The body mass index (BMI), systolic blood pressure, diastolic blood pressure, and serum levels of TG, TC, LDL-C, HDL-C, CTRP-3 and CyPA in three groups were compared by one-way ANOVA, and the least-significant difference (LSD) method was used for further multiple comparisons. The correlations between serum levels of CTRP-3, CyPA and serum levels of TG, TC, LDL-C and HDL-C in PE patients were analyzed by Pearson correlation analysis. And multiple linear regression analysis was used for multivariate analysis for serum levels of CTRP-3, CyPA and lipid metabolism index in PE patients. The procedures followed in this study met the requirements of World Medical Association Declaration of Helsinki revised in 2013. There were no significant differences among three groups in age and gestational age (P>0.05).

Results

①The BMI, systolic blood pressure, diastolic blood pressure and serum levels of TG, TC, LDL-C, HDL-C, CTRP-3 and CyPA were compared among three groups, and all the differences were statistically significant (F=5.138, 6.742, 7.012, 7.436, 6.538, 6.715, 7.213, 27.659, 7.704, P<0.05). Further comparisons showed that BMI, systolic blood pressure, diastolic blood pressure and serum levels of TG, TC, LDL-C and CyPA in severe PE group and mild PE group were significantly higher than those in control group, and all the differences were statistically significant (severe PE group vs control group: LSD-t=7.156, 13.864, 8.664, 14.264, 6.837, 13.875, 28.185, P<0.001; mild PE group vs control group: LSD-t=5.875, 11.673, 7.148, 10.643, 4.184, 11.684, 23.686, P<0.001), while serum levels of HDL-C and CTRP-3 were significantly lower than those in control group, and all the differences also were statistically significant (severe PE group vs control group: LSD-t=12.864, 44.378, P<0.001; mild PE group vs control group: LSD-t=9.547, 31.684, P<0.001). The BMI, systolic blood pressure, diastolic blood pressure and serum levels of TG, TC, LDL-C and CyPA in severe PE group were significantly higher than those in mild PE group, and all the differences were statistically significant (LSD-t=4.738, P<0.001, LSD-t=9.814, P<0.001, LSD-t=4.864, P<0.001, LSD-t=2.326, P=0.042, LSD-t=2.563, P=0.028, LSD-t=2.713, P=0.022, LSD-t=6.145, P<0.001), while serum levels of HDL-C and CTRP-3 were significantly lower than those in mild PE group, and all the differences also were statistically significant (LSD-t=6.258, 16.386, P<0.001). ②Pearson correlation analysis results showed that serum CTRP-3 level was negatively correlated with serum levels of TG, TC and LDL-C in PE patients (r=-0.546, -0.573, -0.601, P<0.001), while positively correlated with serum HDL-C level in PE patients(r=0.531, P<0.001). Serum CyPA level was positively correlated with serum levels of TG, TC and LDL-C in PE patients (r=0.612, 0.637, 0.552, P<0.001), while negatively correlated with serum HDL-C level in PE patients (r=-0.514, P<0.001). ③Multiple linear regression analysis results showed that serum levels of TG, TC, LDL-C and HDL-C were independent influencing factors of serum CTRP-3 and CyPA levels in PE patients (serum CTRP-3 level: t=4.427, P<0.001, t=3.675, P<0.001, t=2.328, P=0.020, t=4.576, P<0.001; serum CyPA level: t=2.788, P=0.005, t=3.332, P=0.001, t=2.429, P=0.015, t=2.140, P=0.032).

Conclusions

Serum CTRP-3 level in PE patient is lower than normal value, and serum CyPA level is higher than normal value. CTRP-3 and CyPA levels are closely related to the abnormal metabolism of lipid in patients with PE, and may be involved in the occurrence and development process of PE.

表1 3组受试者的BMI、收缩压、舒张压总体及两两比较(±s)
表2 3组受试者脂代谢指标总体及两两比较(mmol/L,±s)
表3 3组受试者的血清CTRP-3、CyPA水平总体及两两比较(ng/mL,±s)
表4 PE患者血清CTRP-3水平与其脂代谢指标的多重线性回归分析
表5 PE患者血清CyPA水平与其脂代谢指标的多重线性回归分析
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