Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (05): 486 -492. doi: 10.3877/cma.j.issn.1673-5250.2024.05.002

Special Column of Frontiers in Obstetrics

Interpretation of the Italian guidelines on non-invasive and invasive prenatal diagnosis:executive summary of recommendations for practice the Italian Society for Obstetrics and Gynecology(SIGO)

Jingyu Qian1, Mingming Zheng1,()   

  1. 1.Department of Fetal Medical Center,Anhui Women and Children's Medical Center,Hefei 230001,Anhui Province,China
  • Received:2024-08-01 Revised:2024-09-25 Published:2024-10-01
  • Corresponding author: Mingming Zheng

In 2024,the Italian Society for Obstetrics and Gynecology (SIGO)released the Italianguidelinesonnon-invasiveandinvasiveprenataldiagnosisexecutivesummaryof recommendationsforpracticetheItalianSocietyforObstetricsandGynecologySIGO) (hereinafter referred to as the"PD Guidelines")addressing the application of invasive and non-invasive prenatal diagnosis.The guidelines are founded on the best available evidence from current literature and provide recommendations for common issues in prenatal screening and prenatal diagnosis,aiming to optimize prenatal screening and prenatal diagnosis procedures.The authors intend to compare various prenatal screening protocols in the PD Guidelines,and provide detailed explanations on the recommendations for genetic counseling prior to invasive prenatal diagnosis,recommendations for invasive prenatal diagnosis for pregnant women with infectious diseases,genetic testing items for invasive prenatal diagnosis,and operational requirements.

表1 《PD 指南》证据水平(质量)分级体系
表2 《PD 指南》推荐级别(强度)分级体系
表3 单胎妊娠孕妇NIPT 的胎儿13-、18-和21-三体检出结果比较
表4 NIPT 作为一、二线筛查方案对21-三体综合征胎儿检出结果比较
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