Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (05): 569 -574. doi: 10.3877/cma.j.issn.1673-5250.2024.05.014

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Current research status of correlation between per-and polyfluoroalkyl substances exposure and childhood obesity

Yun Xiang1, You Lu1, Fan Yang1,()   

  1. 1.Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China
  • Received:2024-01-30 Revised:2024-06-30 Published:2024-10-01
  • Corresponding author: Fan Yang

Obesity is a chronic nutritional disorder caused by multiple factors,such as genetics,environment,diet,behavior,diseases,and medications.It is one of the most significant public health challenges of the 21st century.Childhood obesity i ncreases the risk of developing cardiovascular diseases,diabetes,musculoskeletal disorders,and certain types of cancer in adulthood.Per-and polyfluoroalkyl substances (PFAS)are classified as environmental endocrine disruptors(EED)and consist of a large synthetic fluorinated hydrocarbon compounds that have been used since the 1940s.They have stable physicochemical properties and exert various toxic effects on the human body.Currently,a large number of experimental and epidemiological research results have shown that children's exposure to PFAS is closely related to the occurrence of childhood obesity.This article will provide a comprehensive review of the latest research progress on the relationship between PFAS exposure and childhood obesity,the relationship between PFAS's mechanism on abnormal glucose and lipid metabolism and childhood obesity.

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