Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (05): 617 -620. doi: 10.3877/cma.j.issn.1673-5250.2018.05.021

Special Issue:

Review

Research progress of intraoperative cell salvage in obstetrics

Haibing Li1   

  1. 1. Department of Anesthesiology, First Maternity and Infant Hospital Affiliated to Tongji University, Shanghai 201204, China
  • Received:2018-04-08 Revised:2018-06-19 Published:2018-10-01
  • About author:
    Corresponding author: Liu Zhiqiang, Email:
  • Supported by:
    Joint Key Project of Heath and Family Planning Commission of Pudong New District in Shanghai(PW2016D-10); Medical Guiding Project of Shanghai Science and Technology Committee(16411967400)

Intraoperative cell salvage is one of the strategies to avoid allogeneic blood transfusion. Before 1970s, in order to avoid amniotic fluid embolism or maternal immune response, intraoperative cell salvage was almost forbidden in obstetric operations. Intraoperative cell salvage was applied to obstetric operations until the application of leukocyte depletion filter (LDF) in recent years. The level of fetal squamous cells in autologous blood treated with cell saver and filtered by LDF is basically the same as that of maternal vein blood after placenta stripping. So far, there are no definite cases of amniotic fluid embolism due to intraoperative cell salvage reported. For obstetric patients with bleeding who are expected to have a tight blood source, intraoperative cell salvage may be considered. This article mainly reviews research progress of intraoperative cell salvage in obstetrics.

[1]
Waters JH,Biscotti C,Potter PS, et al. Amniotic fluid removal during cell salvage in the cesarean section patient [J]. Anesthesiology, 2000, 92(6): 1531-1536.
[2]
Milne ME,Yazer MH,Waters JH. Red blood cell salvage during obstetric hemorrhage [J]. Obstet Gynecol, 2015, 125(4): 919-923.
[3]
Rudra P,Basak S. Coagulopathy during intraoperative cell salvage in a patient with major obstetric haemorrhage [J]. Br J Anaesth, 2011, 106(2): 280-281.
[4]
Rollins KE,Trim NL,Luddington RJ, et al. Coagulopathy associated with massive cell salvage transfusion following aortic surgery [J]. Perfusion, 2012, 27(1): 30-33.
[5]
Zheng J,Du L,Du G, et al. Coagulopathy associated with cell salvage transfusion following cerebrovascular surgery [J]. Pak J Med Sci, 2013, 29(6): 1459-1461.
[6]
Kudo H,Fujita H,Hanada Y, et al. Cytological and bacteriological studies of intraoperative autologous blood in neurosurgery [J]. Surg Neurol, 2004, 62(3): 195-199; discussion 199-200.
[7]
Shindo S,Matsumoto H,Kubota K, et al. Temporary bacteremia due to intraoperative blood salvage during cardiovascular surgery [J]. Am J Surg, 2004, 188(3): 237-239.
[8]
Waters JH,Tuohy MJ,Hobson DF, et al. Bacterial reduction by cell salvage washing and leukocyte depletion filtration [J]. Anesthesiology, 2003, 99(3): 652-655.
[9]
Allam J,Cox M,Yentis SM. Cell salvage in obstetrics [J]. Int J Obstet Anesth, 2008, 17(1): 37-45.
[10]
Teare KM,Sullivan IJ,Ralph CJ. Is cell salvaged vaginal blood loss suitable for re-infusion? [J]. Int J Obstet Anesth, 2015, 24(2): 103-110.
[11]
Ralph CJ,Sullivan I,Faulds J. Intraoperative cell salvaged blood as part of a blood conservation strategy in Caesarean section: is fetal red cell contamination important? [J]. Br J Anaesth, 2011, 107(3): 404-408.
[12]
Cyr M,Eastlund T,Blais C Jr, et al. Bradykinin metabolism and hypotensive transfusion reactions [J]. Transfusion, 2001, 41(1): 136-150.
[13]
Choi ES,Ahn WS,Lee JM, et al. A laboratory study of the effects of processing blood through a cell salvage device and leucocyte depletion filter on levels of pro-inflammatory cytokines and bradykinin [J]. Anaesthesia, 2013, 68(12): 1259-1265.
[14]
Hussain S,Clyburn P. Cell salvage-induced hypotension and London buses [J]. Anaesthesia, 2010, 65(7): 661-663.
[15]
Rogers WK,Wernimont SA,Kumar GC, et al. Acute hypotension associated with intraoperative cell salvage using a leukocyte depletion filter during management of obstetric hemorrhage due to amniotic fluid embolism [J]. Anesth Analg, 2013, 117(2): 449-452.
[16]
徐涛,王庚,杨庆国. 白细胞滤器对术中自体血回输后促炎-抗炎细胞因子的影响[J]. 重庆医学,2011,40(12):1209-1211.
[17]
张子银. 川芎嗪对自体血回输患者围术期免疫功能的影响[D]. 广州:广州中医药大学,2011.
[18]
杨谦梓,熊利泽.产科手术回收式自体输血安全性的考量[J].中华麻醉学杂志,2016,36(11):1295-1296.
[19]
Jennings A,Brennan C. Cell salvage for obstetric patients who decline blood transfusion: a national survey [J]. Transfus Med, 2013, 23(1): 64-65.
[20]
Catling SJ,Williams S,Fielding AM. Cell salvage in obstetrics: an evaluation of the ability of cell salvage combined with leucocyte depletion filtration to remove amniotic fluid from operative blood loss at caesarean section [J]. Int J Obstet Anesth, 1999, 8(2): 79-84.
[21]
Ashworth A,Klein AA. Cell salvage as part of a blood conservation strategy in anaesthesia [J]. Br J Anaesth, 2010, 105(4): 401-416.
[22]
Goucher H,Wong CA,Patel SK, et al. Cell salvage in obstetrics [J]. Anesth Analg, 2015, 121(2): 465-468.
[23]
Royal College of Obstetricians and Gynaecologists. RCOG Green-top Guideline No. 47. Blood transfusion in obstetrics[EB/OL].(2015-05-29) [2018-04-04].

URL    
[24]
李海冰,方昕,刘志强. 术中自体血回输用于Rh(D)阴性患者剖宫产术一例 [J]. 上海医学,2015,32(12):511-513.
[25]
Brearton C,Bhalla A,Mallaiah S, et al. The economic beneifits of cell salvage in the obstetric haemorrge [J]. Int J Obstet Anesth, 2012, 21(5): 329-333.
[26]
Waters JR,Meier HH,Waters JH. An economic analysis of costs associated with development of a cell salvage program [J]. Anesth Analg, 2007, 104(4): 869-875.
[1] Lu Wang, Yang Fan. Advances in endometrial cancer-related biomarker research[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 511-516.
[2] Ling Wei, Hui Li, Yi Chen. Current research status on colonization or infection and mother-to-child transmission of extended-spectrum β-lactamase-producing Enterobacteriaceae in pregnant and post-partum women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 517-521.
[3] Dan Luo, Weimin Kong, Shuning Chen, Xiaoling Zhao, Yunkai Xie. Differences in epithelial mesenchymal transition-related biological markers between in-situ and ectopic endometrial epithelial cells in endometriosis patients[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 530-539.
[4] Tiantian Chen, Xiaodong Wang, Haiyan Yu. Pregnancy outcome of twin pregnancy with Gitelman syndrome: a case report and literature review[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 559-568.
[5] Xiaoqing Ju, Yunjie Jin, Xiaoyan Wang. Influencing factors of uterine rupture during vaginal delivery in patients with scarred uterus after cesarean section[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 575-581.
[6] Beibei Wang, Qixiu Dong, Hongyan Xi, Qingyun Yu, Lijun Zhang, Guang Shi. Analysis of influencing factors of medical abortion failure of pregnant women in early pregnancy and construction of related prediction model and its predictive value for medical abortion success[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 588-594.
[7] Xu Chen, Yuru Zhan, Chunhua Wang. Clinical value of ABO blood group combined with thyroid function in prediction of gestational diabetes mellitus[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 604-610.
[8] Mengling Zhou, Zhiwei Xue, Shu Zhou. Changes in size of uterine myoma during pregnancy and its association with adverse pregnancy outcomes[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 611-615.
[9] Xingchen Liu, Juan Liu, Baobao Wei, Jie Liu, Hui Liu. Correlation analysis of abnormal expression of XIAP and XAF1 with ovarian cancer[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 419-427.
[10] Chenxi Ran, Rufei Shen, Mingyu Liao, Qian Liao, Ling Zhou, Yuling Zhang, Min Long. Treatment and management of pituitary tumor during pregnancy[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 487-491.
[11] Ying Chen, Yanli Chen. Causes of heart rate variability and perinatal outcomes in elderly pregnant women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(03): 295-301.
[12] Danyan Feng, Xiaohui Cao, Yuxia Shi. Effect of serum adiponectin and placental leucine aminopeptidase levels on pregnancy outcome in pregnant women with gestational diabetes mellitus[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(03): 302-308.
[13] Dingran Wang, Hongbin Chi. Effects of autoimmune thyroiditis on embryo transfer outcomes in patients with endometriosis[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 682-688.
[14] Hongqin Gao, Chen Chen, Ruike Lu, Xiaoyu Wang, Min Zhang, Shaohua Li, Lilan Hao, Xincheng Huang, Lingyao Guan, Yunhong Zhang. Impact of vulvovaginal candidiasis on vaginal-cervical microbiota in women[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 720-725.
[15] Xueyun Liu, Ying Fan, Aijun Yao, Shengmiao Zhang, Yani Lv, Bingqing Zhang, Xiaoyu Zhang, Heng. Liu. Effects of individualized whole-course nursing intervention based on WeChat mini program on pregnancy weight and delivery outcome[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 455-460.
Viewed
Full text


Abstract