Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2014, Vol. 10 ›› Issue (02): 249 -252. doi: 10.3877/cma.j.issn.1673-5250.2014.02.028

Special Issue:

Review

Research Progress of the Roles of Notch Signaling Pathway in Asthma and T Lymphocytes Regulation

Bacuozhen Qiang1, Hanmin Liu2()   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2014-01-10 Revised:2014-03-07 Published:2014-04-01
  • Corresponding author: Hanmin Liu
  • About author:
    (Corresponding author: Liu Hanmin, Email: )

Notch signaling pathway involves in cell differentiation process in a lot of tissues, especially playing an important role in T lymphocytes differentiation process. Recently, many reports have demonstrated that the Notch signaling pathway involves in the whole pathogenesis of bronchial asthma(BA) pathological process, including airway inflammation, airway hyperresponsiveness, airway remodeling and vascular remodeling of the airway. This paper summarizes the roles of Notch signaling pathway in BA and T lymphocyte regulation.

[1]
吴秋歌,王静,周世霞.支气管哮喘患者诱导痰中基质细胞衍生因子的表达及其作用[J].中华结核和呼吸杂志,2011,6(3):423.
[2]
Chu EB,Hobbs MV,Wilsan CB,et al.Intervention of CD4 cell subset shifts and autoimmunity in the RXSB mouse by murine CTLA4Ig[J].J Immunol,1996,156(3):1262-1268.
[3]
Yanagi K,Haneji N,Hamano H,et al.In vivo role of IL-10 and IL-12 during development of sjogren's syndrome in MRL/ Price[J]. Cell Immunol,1996,168(2):243-250.
[4]
van der Meide PH,Groenestein RJ,de Labie MC,et al. Susceptibility to mercuric chloride-induced glomerulonephritis is age-dependent study of the role of IFN-γ[J].Cell Immunol,1995,162(1):131-137.
[5]
Artavanis-Tsakonas S,Rand MD,Lake RJ.Notch signaling:cell fate control and signal integration in development [J].Science,1999,284(5415):770-776.
[6]
Vyttendarele H,Marazzi G.Notch/ int3,a mammary proto oncogenes is an endothelial cell specific mammalian Notch gene[J]. Dev,1996,122(7):2251-2259.
[7]
Gazave E,Lapebie P,Richards GS,et al.Origin and evolution of the Notch signaling pathway: an overview from eukaryotic genomes[J].BMC Evol Biol,2009,9(1):249-276.
[8]
Kopan R,Ilagan MX.The canonical Notch signaling pathway:unfolding the activation mechanism [J].Cell,2009,137(2):216-233.
[9]
王颖,于洁,张芳婷.Notch信号通路与细胞的增殖分化[J].广东医学杂志,2009,30(7):1181-1183.
[10]
Pardali E,Tendijke P.TGF beta signaling and cardiovascular diseases[J].Int J Biol Sci,2012,347(1):195-213.
[11]
Megalou AJ,Glava C,Oikonomidis DL,et al.Transforming growth factor-beta inhibition attenuates pulmonary arterial hypertension in rats[J].Int J Clin Exp Med,2010,3(4):332-340.
[12]
Tsai S,Hollenbeck ST,Ryer EJ,et al.TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation[J].Am J Physiol Heart Circ Physiol,2009,297(2):H540-H549.
[13]
Suwanabol PA,Seedial SM,Yamanouchi D,et al.Transforming growth factor-beta increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulared kinase mitogen-activated protein kinases pathways [J].J Vasc Surg,2012,56(2):446-454.
[14]
Kageyama R,Ohtsuka T,Shimojo H,et al.Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition[J].Nat Neurosci,2008,11(11):1247-1251.
[15]
Herranz H,Milan M.Signaling molecule,growth regulation and cell cycle control in Drosophila[J].Cell Cycle,2008,7(21):3335-3337.
[16]
Traver D,Akashi K,Manz M,et al.Development of CD8 alpha-positive dendritic cells from a common myeloid progenitor[J].Sci,2000,290(5499):2152-2154.
[17]
Cheng P,Zlobin A,Volgina V,et al.Notch1 regulates NF-kappaB activity in hemopoietic progenitor cells[J].J Immunol,2001,167(8):4458-4467.
[18]
Cheng P,Nefedowa Y,Miele L,et al.Notch signaling is necessary but not sufficient for differentiation of dendritic cells[J].Blood,2003,102(12):3980-3988.
[19]
翁建宇,黄欣,赖沛龙,等.间充质干细胞诱导小鼠CD8+CD11+ jagged2(high)调节性树突状细胞的方法[J].细胞与分子免疫学杂志,2012,28(6):568-571.
[20]
Krishnamoorthy N,Oriss TB,Paglia M,et al.Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma[J].Nat Med,2008,14(5):565-573.
[21]
郑凯,谭建明,吴卫真,等.大鼠Delta1基因真核表达载体的构建与鉴定[J].中国组织工程研究与临床康复,2010,14(18):3331-3334.
[22]
Okamoto M,Matsuda H,Joetham A,et al.Jagged1 on dendritic cells and notch on CD4+T cells initiate lung allergic responsiveness by inducing IL-4 production[J].J Immunol,2009,183(5):2995-3003.
[23]
Lewis KL,Caton ML,Bogunovic M,et al.Notch2 receptor signaling controls function differentiation of dendritic cells in the spleen and intestine[J].Immunity,2011,35(5):780-791.
[24]
Cheng P,Nefedova Y,Corzo CA,et al.Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands[J].Blood,2007,109(2):507-515.
[25]
Amsen D,Antov A,Flavell RA.The different faces of Notch in T-helper-cell differentiation[J].Nat Rev Immunol,2009,9(2):116-124.
[26]
秦一鸣,张红星,蒋延旺,等.Notch信号通路在小儿哮喘患者外周血单核细胞的表达及其临床意义[J].临床军医杂志,2009,40(2):419-421.
[27]
Daegelmann C,Herberth G,Roder S,et al.Association between suppressors of cytokine signaling,T-helper type1/T-helper type2 balance and allergic sensitization in children[J].Clin Exp Allergy,2008,38(3):438-448.
[28]
Yoshimura A,Naka T,Kubo M.SOCS proteins, cytokine signaling and immune regulation [J].Nat Rev Immunol,2007,7(6):454-465.
[29]
Efforts RM,Nagaraj H.Asthma:new developments concerning immune mechanisms,diagnosis and treatment[J].Curropin Pulm Med,2007,13(1):37-43.
[30]
Guo XJ,Zhou M,Ren LP,et al.Small interfering RNA-mediated knockdown of Notch1 in lung[J].Chin Med,2009,122(21):2647-2651.
[31]
唐丹,梁萍,苏培媛.支气管哮喘患儿Th1/ Th2细胞免疫平衡变化研究[J].中国医药科学,2011,1(10):43-44.
[32]
惠郁,谢娟娟,张晓娟,等.哮喘儿童细胞因子信号转导抑制因子mRNA表达与Th1/ Th2的关系[J].中国当代儿科杂志,2012,14(10):755-758.
[33]
周敏,郭雪君.γ分泌酶抑制剂阻断Notch信号对支气管哮喘模型小鼠气道炎症的影响[J].中华哮喘杂志,2012,6(1):7-11.
[34]
苗丽丽,王玉华,王磊,等.Notch1信号调控小鼠胸腺T细胞凋亡的机制研究[J].中国免疫学杂志,2013,258(4):339-343.
[35]
Barnes PJ.The cytokine network in asthma and chronic obstructive pulmonary disease[J].Clin Invest,2008,118(11):3546-3556.
[36]
Barnes PJ.Immunology of asthma and chronic obstructive pulmonary disease[J].Nat Rev Immunol,2008,8(3):183-192.
[37]
崇蕾,张维溪,聂颖,等.Notch2, Notch4受体在哮喘小鼠肺中的表达及布地奈德、姜黄素对其影响[J].医学研究杂志,2012,41(4):73-75.
[38]
Fang TC,Yashiro-Ohtani Y,DelBianco C,et al.Notch directly regulates Gata3 expression during T helper2 cell differentiation[J].Immun,2007,27(1):100-110.
[39]
Koya T,Miyahara N,Takeda K,et al.CD8 T cell-mediated airway hyperresponsiveness and inflammation is dependent on CD4 IL-4 T cells[J].J Immunol,2007,179(5):2787-2796.
[40]
Huang MT,Dai YS,Chou YB,et al.Regulatory T cells negatively regulate neovasculature of airway remodeling via DLL4-Notch signaling[J].J Immunol,2009,183(7):4745-4754.
[41]
Havrda MC,Johnson MJ,Liaw L.A novel mechanism of transcriptional repression of through Notch/ HRT2 signaling in vascular smooth muscle cells[J].Thromb Haemost,2006,96(3):361-370.
[42]
Doi H,Sato H,Tanaka T,et al.Jagged1-selective Notch signaling induces smooth muscle differentiation via a RBP-J kappa-dependent pathway[J].Biol Chem,2006,281(39):28555-28564.
[43]
Noseda M,Niessem K,Mclean G,et al.Smooth muscle alpha-actin is a direct target of Notch/ CSL[J].Circ Res,2006,98(12):1468-1470.
[44]
栾斌,冯晓霞,杨玉霞,等.FISS1及NOTCH1在哮喘中的作用[J].中国当代儿科杂志,2011,13(3):219-222.
[45]
Moore WC,Meyers DA,Wenzel SE,et al.National Heart,Lung,and Blood Institutes Severe Asthma Research Program; Identification of asthma phenotypes using duster analysis in the Severe Asthma Research Program[J].Am J Respir Crit Care Med,2010,181(4):315-323.
[46]
Wenzel SE.Asthma:defining of the persistent adult phenotypes[J].Lancet,2006,368(9537):804-813.
[47]
Huber HL,Koessler KK.The pathology of bronchial asthma[J]. Arch Int Med,1922,30(6):689-760.
[48]
Hoshino M,Aoike N,Takahashi M,et al.Increased immunoreactivity of stromal cell-derived factor and angiogenesis in asthma[J].Eur Respir J,2003,21(5):804-809.
[49]
Rydell-Tormanen K,Uller L,Erjefalt JS.Remodeling of extra-bronchial lung vasculature following allergic airway inflammation[J].Respir Res,2008,9:18.
[50]
Hoffmann JJ,Iruela-Arispe ML.Notch signaling in blood vessels:who is talking to whom about what[J].Cirs Res,2007,100(11):1556-1568.
[1] Chen Luo, Kaican Zong, Shiying Li, Yingya Fu. MicroRNA-199a-3p participates in the immune response after Mycoplasma pneumoniae infection in children by regulating the expression of CD4+ T cells[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 569-574.
[2] Haoyuan Yang, Jie Gong, Qingwei Zou, Hang Ruan. Current research status on adverse pregnancy outcomes of maternal and infant in pregnant women with asthma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 522-529.
[3] Lili Lou, Hanmin Liu. Current research status of susceptibility genes and epigenetics on childhood asthma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(03): 249-255.
[4] Jinli Yan, Dapeng Chen. Research progress on probiotics in clinical application of neonatal respiratory diseases[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(05): 517-522.
[5] Dongmei Liang, Yan Wang, Jun Dai. Current research status on relationship between regulatory T cells and endometriosis[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(06): 627-633.
[6] Weixia Cai, Tao Cao, Ming Zhao, Dan Xiao, Yanhui Jia, Jing Wang, Yue Zhang, Kejia Wang, Juntao Han, Dahai Hu. Effects of Notch signaling pathway on the intercellular adhesion molecule-1 of pulmonary vascular endothelial cell induced by serum in burned rats[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(04): 292-299.
[7] Jian Cui, Qing Dai. The relationship between the proportion of Treg cells and anaphylaxis was studied based on anaphylaxis model induced by hepatic cystic echinococcosis[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(04): 427-430.
[8] Yuan Zhang, Xiaolong Li, Yapeng Wang. Relationship between ANGPTL2 protein and immunosuppressive cell infiltration in pancreatic cancer and its clinical significance[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(02): 145-148.
[9] Xiaopeng Zeng, Lixin Fan, Chengsong Li, Kunpeng Liu, Xiongcai Zhou, Zhihua Wang, Xiaosheng Li. Relationship between CD4+ T-lymphocyte levels and perioperative infection in urological endoscopic surgery in HIV/AIDS patients[J]. Chinese Journal of Endourology(Electronic Edition), 2021, 15(06): 502-506.
[10] Lingfang Tan, Kebing Zhou. Identification of biomarkers associated with diagnosis of bronchial asthma based on integrated bioinformatics analysis[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2023, 16(03): 329-334.
[11] Chao Zhang, Xiaozhe Yue. Association of eosinophils, total IgE with severity and lung function in children with asthma[J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(02): 183-186.
[12] Lili Yin, Chen Guan, Long Zhao, Wei Jiang, Zhenzhi Qin, Chenyu Li, Yan Xu. Potential molecular mechanism of astaxanthin regulating renal interstitial fibrosis through CCN1[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(06): 318-326.
[13] Jingen Xia, Shiyu Hu. Application scenario of extracorporeal carbon dioxide removal technology in Intensive Care Unit[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(01): 40-45.
[14] Xiaoning Zhang, Jianguang Qi. Progress in application of shared decision-making in children with bronchial asthma[J]. Chinese Journal of Clinicians(Electronic Edition), 2021, 15(07): 542-546.
[15] Ru Fan, Yuqing Liu, Xiaorong Hu, Yiqi Wang, Fen Zhang, Xing Cen, Yujie Bu, Junwei Chen. Changes of lncRNA expression and its correlation with CD8+ T cells in patients with systemic lupus erythematosus[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(03): 184-189.
Viewed
Full text


Abstract