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中华妇幼临床医学杂志(电子版) ›› 2025, Vol. 21 ›› Issue (03) : 266 -270. doi: 10.3877/cma.j.issn.1673-5250.2025.03.003

专家述评

妇科恶性肿瘤年轻患者生育力保存的临床实践与挑战
王秋毅, 黄薇()   
  1. 四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验,成都 610041
  • 收稿日期:2025-02-02 修回日期:2025-05-28 出版日期:2025-06-01
  • 通信作者: 黄薇

Fertility preservation in young patients with gynecological malignancies: clinical practices and challenges

Qiuyi Wang, Wei Huang()   

  1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2025-02-02 Revised:2025-05-28 Published:2025-06-01
  • Corresponding author: Wei Huang
  • Supported by:
    National Key Research & Development Program of China(2023YFC2705502)
引用本文:

王秋毅, 黄薇. 妇科恶性肿瘤年轻患者生育力保存的临床实践与挑战[J/OL]. 中华妇幼临床医学杂志(电子版), 2025, 21(03): 266-270.

Qiuyi Wang, Wei Huang. Fertility preservation in young patients with gynecological malignancies: clinical practices and challenges[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2025, 21(03): 266-270.

妇科恶性肿瘤年轻患者的生育力保存(FP),已成为妇科肿瘤治疗临床决策的重要一环。随着妇科恶性肿瘤患者年轻化和治疗技术进步,年轻患者对FP的需求日益增加。目前临床常用的FP方法包括胚胎冷冻、卵母细胞冷冻、卵巢组织冷冻(OTC)和未成熟卵母细胞体外成熟(IVM)。笔者拟就妇科恶性肿瘤年轻患者FP的必要性、流程和关键技术的最新研究现状进行阐述,旨在为妇科恶性肿瘤年轻患者FP的临床实践及临床如何应对相应挑战提供参考。

Fertility preservation (FP) in young women with gynecological malignancies has emerged as a critical component of clinical decision-making. With the increasing incidence of these malignancies among young women and advancements in therapeutic strategies, there is a growing demand for FP options among them. Current FP methodologies include embryo cryopreservation, oocyte vitrification, ovarian tissue cryopreservation (OTC), and in vitro maturation (IVM) of immature oocytes. This review systematically examines the clinical necessity of FP, elucidates standardized protocols for its implementation, and evaluates key technological innovations, aiming to provide evidence-based guidance for optimizing FP integration into gynecologic oncology practice and how to deal with the challenges in clinic.

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