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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (02) : 245 -248. doi: 10.3877/cma.j.issn.1673-5250.2022.02.018

综述

孕酮受体在人子宫内膜基质细胞蜕膜化过程中的作用机制研究现状
黄品秀, 曾定元()   
  1. 广西壮族自治区柳州市妇幼保健院生殖医学中心 545001
  • 收稿日期:2021-10-30 修回日期:2022-02-25 出版日期:2022-04-01
  • 通信作者: 曾定元

Current research status of mechanism of progesterone receptor in human endometrial stroma cell deciduation

Pinxiu Huang, Dingyuan Zeng()   

  1. Reproductive Medicine Center, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou 545001, Guangxi Zhuang Autonomous Region, China
  • Received:2021-10-30 Revised:2022-02-25 Published:2022-04-01
  • Corresponding author: Dingyuan Zeng
  • Supported by:
    National Natural Science Foundation of China(82001553, 82160296); Natural Science Foundation of Guangxi Zhuang Autonomous Region(2019JJB140179); Key Research and Development Program of Guangxi Zhuang Autonomous Region(Guike AB18126056); Key Research and Development Program of Liuzhou(2018BJ10301); Scientific and Technology Development Project of Liuzhou(2018DB20501)
引用本文:

黄品秀, 曾定元. 孕酮受体在人子宫内膜基质细胞蜕膜化过程中的作用机制研究现状[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(02): 245-248.

Pinxiu Huang, Dingyuan Zeng. Current research status of mechanism of progesterone receptor in human endometrial stroma cell deciduation[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(02): 245-248.

人子宫内膜基质细胞蜕膜化(hESCD),是人类胚胎植入和维持妊娠的关键环节。hESCD主要是指排卵后,子宫内膜在孕酮与孕酮受体(PGR)作用下,发生一系列生物学、形态学改变及细胞外基质重建。但是,对于孕酮-PGR信号通路在hESCD过程中的具体分子作用机制,迄今尚未阐明。笔者拟就PGR结构及其亚型,hESCD过程中孕酮-PGR信号通路的生理作用、网络调控,以及PGR水平及其功能异常与hESCD异常疾病关系4个方面的最新研究进展进行阐述。

Human endometrial stroma cell decidualization (hESCD) is a key link in embryo implantation and pregnancy maintenance. hESCD mainly means that endometrium undergoes a series of biological and morphological changes and extracellular matrix reconstruction by effects of progesterone and progesterone receptor (PGR) after ovulation. However, up to now, the specific molecular mechanism of progesterone-PGR signal pathway in hESCD has not been fully elucidated. This paper focuses on recent research status of the structure and subtypes of PGR, physiological function and regulation network of progesterone-PGR signal pathway, and relationship between abnormal PGR and abnormal diseases of hESCD.

图1 PGR结构域示意图注:PGR为孕酮受体。AF为活化功能结构域,IF为抑制功能结构域,DBD为DNA结合域,LBD为配体结合域
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