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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (02) : 245 -248. doi: 10.3877/cma.j.issn.1673-5250.2022.02.018

综述

孕酮受体在人子宫内膜基质细胞蜕膜化过程中的作用机制研究现状
黄品秀, 曾定元()   
  1. 广西壮族自治区柳州市妇幼保健院生殖医学中心 545001
  • 收稿日期:2021-10-30 修回日期:2022-02-25 出版日期:2022-04-01
  • 通信作者: 曾定元

Current research status of mechanism of progesterone receptor in human endometrial stroma cell deciduation

Pinxiu Huang, Dingyuan Zeng()   

  1. Reproductive Medicine Center, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou 545001, Guangxi Zhuang Autonomous Region, China
  • Received:2021-10-30 Revised:2022-02-25 Published:2022-04-01
  • Corresponding author: Dingyuan Zeng
  • Supported by:
    National Natural Science Foundation of China(82001553, 82160296); Natural Science Foundation of Guangxi Zhuang Autonomous Region(2019JJB140179); Key Research and Development Program of Guangxi Zhuang Autonomous Region(Guike AB18126056); Key Research and Development Program of Liuzhou(2018BJ10301); Scientific and Technology Development Project of Liuzhou(2018DB20501)
引用本文:

黄品秀, 曾定元. 孕酮受体在人子宫内膜基质细胞蜕膜化过程中的作用机制研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2022, 18(02): 245-248.

Pinxiu Huang, Dingyuan Zeng. Current research status of mechanism of progesterone receptor in human endometrial stroma cell deciduation[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(02): 245-248.

人子宫内膜基质细胞蜕膜化(hESCD),是人类胚胎植入和维持妊娠的关键环节。hESCD主要是指排卵后,子宫内膜在孕酮与孕酮受体(PGR)作用下,发生一系列生物学、形态学改变及细胞外基质重建。但是,对于孕酮-PGR信号通路在hESCD过程中的具体分子作用机制,迄今尚未阐明。笔者拟就PGR结构及其亚型,hESCD过程中孕酮-PGR信号通路的生理作用、网络调控,以及PGR水平及其功能异常与hESCD异常疾病关系4个方面的最新研究进展进行阐述。

Human endometrial stroma cell decidualization (hESCD) is a key link in embryo implantation and pregnancy maintenance. hESCD mainly means that endometrium undergoes a series of biological and morphological changes and extracellular matrix reconstruction by effects of progesterone and progesterone receptor (PGR) after ovulation. However, up to now, the specific molecular mechanism of progesterone-PGR signal pathway in hESCD has not been fully elucidated. This paper focuses on recent research status of the structure and subtypes of PGR, physiological function and regulation network of progesterone-PGR signal pathway, and relationship between abnormal PGR and abnormal diseases of hESCD.

图1 PGR结构域示意图注:PGR为孕酮受体。AF为活化功能结构域,IF为抑制功能结构域,DBD为DNA结合域,LBD为配体结合域
[1]
Gellersen B, Brosens JJ. Cyclic decidualization of the human endometrium in reproductive health and failure[J]. Endocr Rev, 2014, 35(6): 851-905. DOI: 10.1055/s-2007-991042.
[2]
DeMayo FJ, Lydon JP. 90 years of progesterone: new insights into progesterone receptor signaling in the endometrium required for embryo implantation[J]. J Mol Endocrinol, 2020, 65(1): T1-T14. DOI: 10.1530/JME-19-0212.
[3]
McKinnon B, Mueller M, Montgomery G. Progesterone resistance in endometriosis: an acquired property?[J]. Trends Endocrinol Metab, 2018, 29(8): 535-548. DOI: 10.1016/j.tem.2018.05.006.
[4]
Cenciarini ME, Proietti CJ. Molecular mechanisms underlying progesterone receptor action in breast cancer: insights into cell proliferation and stem cell regulation[J]. Steroids, 2019, 152: 108503. DOI: 10.1016/j.steroids.2019.108503.
[5]
Xin QL, Qiu JT, Cui S, et al. Transcriptional activation of nuclear estrogen receptor and progesterone receptor and its regulation[J]. Sheng Li Xue Bao, 2016, 68(4): 435-454.
[6]
Chi RA, Wang T, Adams N, et al. Human endometrial transcriptome and progesterone receptor cistrome reveal important pathways and epithelial regulators[J]. J Clin Endocrinol Metab, 2020105(4): e1419-e1439. DOI: 10.1210/clinem/dgz117.
[7]
Bairagi S, Grazul-Bilska AT, Borowicz PP, et al. Placental development during early pregnancy in sheep: progesterone and estrogen receptor protein expression[J]. Theriogenology, 2018, 114: 273-284. DOI: 10.1016/j.theriogenology.2018.04.002.
[8]
Refeat MM, Shalabi T, El-Bassyouni HT, et al. The correlation of estrogen receptor 1 and progesterone receptor genes polymorphisms with recurrent pregnancy loss in a cohort of Egyptian women[J]. Mol Biol Rep, 2021, 48(5): 4413-4420. DOI: 10.1007/s11033-021-06459-x.
[9]
Yilmaz BD, Bulun SE. Endometriosis and nuclear receptors[J]. Hum Reprod Update, 2019, 25(4): 473-485. DOI: 10.1093/humupd/dmz005.
[10]
Saviano P, Fiorucci L, Grande F, et al. Pregnancy and fetal development: cephalic presentation and other descriptive ultrasonographic findings from clinically healthy bottlenose dolphins (tursiops truncatus) under human care[J]. Animals (Basel), 2020, 10(5): 908. DOI: 10.1093/humupd/dmz005.
[11]
Marinić M, Lynch VJ. Relaxed constraint and functional divergence of the progesterone receptor (PGR) in the human stem-lineage[J]. PLoS Genet, 2020, 16(4): e1008666. DOI: 10.1371/journal.pgen.1008666.
[12]
Bluming AZ. Progesterone and breast cancer pathogenesis[J]. J Mol Endocrinol, 2021, 66(1): C1-C2. DOI: 10.1530/JME-20-0262.
[13]
Mulac-Jericevic B, Mullinax RA, DeMayo FJ, et al. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform[J]. Science, 2000, 289(5485): 1751-1754. DOI: 10.1126/science.289.5485.1751.
[14]
Gupta A, Gupta G, Mehta RR, et al. A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture[J]. Biol Open, 2020, 9(5): bio051649. DOI: 10.1242/bio.051649.
[15]
Bhurke AS, Bagchi IC, Bagchi MK. Progesterone-regulated endometrial factors controlling implantation[J]. Am J Reprod Immunol, 2016, 75(3): 237-245. DOI: 10.1111/aji.12473.
[16]
Albaghdadi AJH, Kan FWK. Immunosuppression with tacrolimus improved implantation and rescued expression of uterine progesterone receptor and its co-regulators FKBP52 and PIASy at nidation in the obese and diabetic mice: comparative studies with metformin[J]. Mol Cell Endocrinol, 2018, 460: 73-84. DOI: 10.1016/j.mce.2017.07.007.
[17]
Daikoku T, Tranguch S, Friedman DB, et al. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus[J]. Mol Endocrinol, 2005, 19(3): 683-697. DOI: 10.1210/me.2004-0332.
[18]
Rekawiecki R, Dobrzyn K, Kotwica J, et al. Progesterone receptor coregulators as factors supporting the function of the corpus luteum in cows[J]. Genes, 202011(8): 923. DOI: 10.3390/genes11080923.
[19]
Wu SP, Li R, DeMayo FJ. Progesterone receptor regulation of uterine adaptation for pregnancy[J]. Trends Endocrinol Metab, 2018, 29(7): 481-491. DOI: 10.1016/j.tem.2018.04.001.
[20]
Okada H, Tsuzuki T, Murata H. Decidualization of the human endometrium[J]. Reprod Med Biol, 2018, 17(3): 220-227. DOI: 10.1002/rmb2.12088.
[21]
Horton J, Sterrenburg M, Lane S, et al. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and Meta-analysis[J]. Hum Reprod Update, 2019, 25(5): 592-632. DOI: 10.1093/humupd/dmz012.
[22]
Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations[J]. Lancet, 2021, 397(10276): 839-852. DOI: 10.1016/S0140-6736(21)00389-5.
[23]
孙慧清,盖凌,张立宏,等. 重复性早期流产患者雌、孕激素及其受体研究[J]. 生殖与避孕1995, 15(3): 180-185.
[24]
Liu L, Cheng J, Wei F, et al. The influence mechanism of abnormal immunophilin FKBP52 on the expression levels of PR-A and PR-B in endometriosis based on endometrial stromal cell model in vitro[J]. Organogenesis, 2021, 17(1-2): 1-13. DOI: 10.1080/15476278.2020.1860424.
[25]
Xin Q, Kong S, Yan J, et al. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation[J]. J Clin Invest, 2018, 128(1): 175-189. DOI: 10.1172/JCI92862.
[27]
Donnez J, Dolmans MM. Endometriosis and medical therapy: from progestogens to progesterone resistance to GnRH antagonists: a review[J]. J Clin Med, 2021, 10(5): 1085. DOI: 10.3390/jcm10051085.
Knutson TP, Truong TH, Ma S, et al. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs[J]. J Hematol Oncol, 2017, 10(1): 89. DOI: 10.1186/s13045-017-0462-7.
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