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中华妇幼临床医学杂志(电子版) ›› 2023, Vol. 19 ›› Issue (02) : 151 -155. doi: 10.3877/cma.j.issn.1673-5250.2023.02.005

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女性生殖道微生物群与辅助生殖技术相关性研究现状
魏权1, 张燊1, 陈慧佳1, 邹姮1, 胡丽娜1,2,()   
  1. 1重庆医科大学附属第二医院妇产科,重庆 404100
    2重庆医科大学感染与免疫临床研究学科创新引智基地(D20028),重庆 404100
  • 收稿日期:2022-11-29 修回日期:2023-03-02 出版日期:2023-04-01
  • 通信作者: 胡丽娜

Current research progress on correlation between female reproductive tract microbiota and assisted reproductive technology

Quan Wei1, Shen Zhang1, Huijia Chen1, Heng Zou1, Lina Hu1,2,()   

  1. 1Department of Obstetrics and Gynaecology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 404100, China
    2Infection & Immunity Clinical Study Overseas Expertise Introduction Center for Discipline Innovation of Chongqing Medical University(D20028), Chongqing 404100, China
  • Received:2022-11-29 Revised:2023-03-02 Published:2023-04-01
  • Corresponding author: Lina Hu
  • Supported by:
    Joint Medical Research Project of Chongqing Science and Technology Bureau and Health Commission(2022QNXM023)
引用本文:

魏权, 张燊, 陈慧佳, 邹姮, 胡丽娜. 女性生殖道微生物群与辅助生殖技术相关性研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(02): 151-155.

Quan Wei, Shen Zhang, Huijia Chen, Heng Zou, Lina Hu. Current research progress on correlation between female reproductive tract microbiota and assisted reproductive technology[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(02): 151-155.

女性生殖道(FRT)各部位定植固有微生物中,子宫内膜种类低于阴道,处于稳态的微生物维持FRT正常生理功能。辅助生殖技术(ART)作为治疗女性不孕症的主要手段,其胚胎移植成功率低是目前关注的核心问题。FRT菌群失调影响ART胚胎着床的具体作用机制迄今尚未阐明。最新研究发现,乳酸杆菌丰度下降,其他杂菌数量增加导致的菌群失衡,可致子宫内膜微环境异常,影响子宫内膜容受性,阻碍胚胎植入、着床过程,最终导致胚胎植入失败等不良妊娠结局。笔者拟就目前关于FRT微生物群和ART相关研究的最新进展进行阐述,旨在提高ART治疗不孕症的成功率。

Resident bacteria exist in the female reproductive tract (FRT), among which the endometrial microbial species is lower than that of vagina, and normal microbiome plays a role in maintaining the normal physiological functions of reproductive tract. Assisted reproductive technology (ART) is functioned as the main treatment for female infertility, the overall clinical pregnancy rate of which is still low. The specific mechanism by which dysbiosis of the FRT affects ART embryo implantation is still not completely understood yet. Recent studies have found that microbial dysbioses such as decrease in abundance of Lactobacillus and increase in number of other pathogenic bacteria can lead to an abnormal endometrial microenvironment. The imbalance of ART microbiome would affect the endometrial receptivity and hinder the embryo implantation process, ultimately leading to the failure of embryo implantation and other adverse pregnancy outcomes. The author intends to review the latest progress of current research related to FRT microbiome and ART, to improve ART success rate of infertility.

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