切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2023, Vol. 19 ›› Issue (04) : 403 -409. doi: 10.3877/cma.j.issn.1673-5250.2023.04.005

专题论坛

子宫内膜癌患者淋巴管间隙浸润预测因素研究现状
韩春颖, 王婷婷, 李艳艳, 朴金霞()   
  1. 吉林省肿瘤医院妇瘤三科,长春 130012
  • 收稿日期:2023-01-08 修回日期:2023-07-01 出版日期:2023-08-01
  • 通信作者: 朴金霞

Current research status on predictors of lymphatic vascular invasion in patients with endometrial carcinoma

Chunying Han, Tingting Wang, Yanyan Li, Jinxia Piao()   

  1. Department of Gynecology and Oncology-3, Jilin Provincial Cancer Hospital, Changchun 130012, Jilin Province, China
  • Received:2023-01-08 Revised:2023-07-01 Published:2023-08-01
  • Corresponding author: Jinxia Piao
  • Supported by:
    Science and Technology Development Plan Project of Jilin Province(20200403096SF)
引用本文:

韩春颖, 王婷婷, 李艳艳, 朴金霞. 子宫内膜癌患者淋巴管间隙浸润预测因素研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 403-409.

Chunying Han, Tingting Wang, Yanyan Li, Jinxia Piao. Current research status on predictors of lymphatic vascular invasion in patients with endometrial carcinoma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 403-409.

淋巴管间隙浸润(LVSI)状态,是影响子宫内膜癌(EC)患者的预后因素之一。目前对LVSI状态,主要依靠手术切除组织标本的组织病理学检测结果进行判断,尚具有一定局限性。关于LVSI状态预测EC患者预后的相关研究的分子水平检测,包括DNA及RNA与相关蛋白检测,这些均有助于预测EC患者的LVSI状态。根据EC患者临床数据开发的LVSI风险预测模型,如影像学数据及肿瘤标志物等相关预测模型,均可有助于临床判断LVSI状态,从而预测EC患者预后。笔者拟就目前关于EC患者LVSI状态的分子预测、免疫组织化学预测及LVSI状态风险预测模型的最新研究进展现状进行阐述,旨在为临床对EC患者的诊断及治疗方案制定提供参考。

Lymphatic vascular infiltration (LVSI) is one of the prognostic factors for patients with endometrial cancer(EC), but LVSI mainly depends on pathological analysis of surgical specimens, which has certain limitations. In recent years, preliminary progress has been made in the prediction of LVSI, such as molecular level detection, including DNA, RNA and related protein detection, which can help to predict LVSI status. Predictive models developed from clinical data can also aid in clinical judgment LVSI in patients with EC. The author intends to review the latest research progresses on molecular prediction, immunohistochemistry prediction, and related risk model prediction of LVSI status in patients with EC, with the aim of providing reference for clinical diagnosis and treatment planning of EC.

[1]
周蓉,鹿群,刘国莉,等.早期子宫内膜癌保留生育功能治疗专家共识[J].中国妇产科临床杂志2019, 20(4): 369-373. DOI: 10.13390/j.issn.1672-1861.2019.04.025.
[2]
Fan Z, Li H, Hu R, et al. Fertility-preserving treatment in young women with grade 1 presumed stage IA endometrial adenocarcinoma: A Meta-analysis [J]. Int J Gynecol Cancer, 2018, 28(2): 385-393. DOI: 10.1097/IGC.0000000000001164.
[3]
Gonthier C, Douhnai D, Koskas M. Lymph node metastasis probability in young patients eligible for conservative management of endometrial cancer [J]. Gynecol Oncol, 2020, 157(1): 131-135. DOI:10.1016/j.ygyno.2020.02.021.
[4]
Peters EEM, León-Castillo A, Smit VTHBM, et al. Defining substantial lymphovascular space invasion in endometrial cancer [J]. Int J Gynecol Pathol, 2022, 41(3): 220-226. DOI: 10.1097/PGP.0000000000000806.
[5]
Raffone A, Travaglino A, Raimondo D, et al. Lymphovascular space invasion in endometrial carcinoma: a prognostic factor independent from molecular signature [J]. Gynecol Oncol, 2022, 165(1): 192-197. DOI: 10.1016/j.ygyno.2022.01.013.
[6]
Koskas M, Amant F, Mirza MR, et al. Cancer of the corpus uteri: 2021 update [J]. Int J Gynaecol Obstet, 2021, 155(Suppl 1): 45-60. DOI: 10.1002/ijgo.13866.
[7]
中国抗癌协会妇科肿瘤专业委员会.子宫内膜癌诊断与治疗指南(2021年版)[J].中国癌症杂志2021, 31(6): 501-512. DOI: 10.19401/j.cnki.1007-3639.2021.06.08.
[8]
Nicole C, Xavier GM, Ignace V, et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma [J]. Int J Gynecol Cancer, 2020, 31(1): 12-39. DOI:10.1136/IJGC-2020-002230.
[9]
Watanabe T, Honma R, Kojima M, et al. Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis [J]. PLoS One, 2019, 14(9): e0223178. DOI: 10.1371/journal.pone.0223178.
[10]
Li Y, Qu J, Sun Y, et al. Troponin T1 promotes the proliferation of ovarian cancer by regulating cell cycle and apoptosis [J]. Iran J Biotechnol, 2023, 21(1): e3405. DOI: 10.30498/ijb.2022.344921.3405.
[11]
Mannelqvist M, Stefansson IM, Bredholt G, et al. Gene expression patterns related to vascular invasion and aggressive features in endometrial cancer [J]. Am J Pathol, 2011, 178(2): 861-871. DOI: 10.1016/j.ajpath.2010.10.040.
[12]
Concin N, Matias-Guiu X, Vergote I, et al. ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma [J]. Int J Gynecol Cancer, 2021, 31(1): 12-39. DOI: 10.1136/ijgc-2020-002230.
[13]
Yang BH, Yu MX, Xu J, et al. The value of DNA quantitative cytology test for the screening of endometrial cancer [J]. Cancer Manag Res, 201911: 10383-10391. DOI: 10.2147/CMAR.S225672.
[14]
Svanvik T, Strmberg U, Holmberg E, et al. DNA ploidy status, S-phase fraction, and p53 are not independent prognostic factors for survival in endometrioid endometrial carcinoma FIGO stage I-III [J]. Int J Gynecol Cancer, 2019, 29(2): 305-311. DOI: 10.1136/ijgc-2018-000082.
[15]
Patthey A, Boman K, Tavelin B, et al. Combination of aneuploidy and high S-phase fraction indicates increased risk of relapse in stage I endometrioid endometrial carcinoma [J]. Acta Oncol, 2021, 60(9): 1218-1224. DOI: 10.1080/0284186X.2021.1939146.
[16]
Bolivar AM, Luthra R, Mehrotra M,et al. Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients [J]. Mod Pathol, 2019, 32(3): 405-414. DOI: 10.1038/s41379-018-0158-8.
[17]
Ronchetti L, Terrenato I, Ferretti M, et al. Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer [J]. J Exp Clin Cancer Res, 2022, 41(1): 151. DOI: 10.1186/s13046-022-02359-5.
[18]
Vizza E, Corrado G, De Angeli M, et al. Serum DNA integrity index as a potential molecular biomarker in endometrial cancer [J]. J Exp Clin Cancer Res, 2018, 37(1): 16. DOI:10.1186/s13046-018-0688-4.
[19]
Gressel GM, Maggi EC, Harmon BE, et al. Low molecular weight serum cell-free DNA concentration is associated with clinicopathologic indices of poor prognosis in women with uterine cancer [J]. J Transl Med, 202018(1): 323. DOI:10.1186/s12967-020-02493-8.
[20]
Shintani D, Hihara T, Ogasawara A, et al. Tumor-related mutations in cell-free DNA in preoperative plasma as a prognostic indicator of recurrence in endometrial cancer [J]. Int J Gynecol Cancer, 2020, 30(9): 1340-1346. DOI: 10.1136/ijgc-2019-001053.
[21]
Zhou H, Gao Z, Wan F. Taurine-upregulated gene 1 contributes to cancers through sponging microRNA [J]. Acta Biochim Biophys Sin (Shanghai), 2019, 51(2): 123-130. DOI: 10.1093/abbs/gmy156.
[22]
Chen Q, Schatz C, Cen Y, et al. LncRNA TUG1 promotes the migration and invasion in type I endometrial carcinoma cells by regulating E-N cadherin switch [J]. Taiwan J Obstet Gynecol, 2022, 61(5): 780-787. DOI: 10.1016/j.tjog.2022.03.045.
[23]
Metovic J, Borella F, D′Alonzo M, et al. FOXA1 in breast cancer: a luminal marker with promising prognostic and predictive impact [J]. Cancers (Basel), 2022, 14(19): 4415-4421. DOI:10.3390/cancers14194699.
[24]
Yildiz ON, Topal CS, Zemheri IE. Diagnostic importance of PAX2, ARID1A, and FOXA1 biomarkers in atypical endometrial hyperplasia [J]. J Coll Physicians Surg Pak, 2023, 33(8): 847-851. DOI: 10.29271/jcpsp.2023.08.847.
[25]
Tosun YH, Nergiz D, Sadullaho?lu C, et al. FOXA1 is associated with high tumor grade, myometrial invasion and lymph node invasion in endometrial endometrioid carcinoma [J]. Ginekol Pol, 2021, 92(8): 544-549. DOI: 10.5603/GP.a2021.0016.
[26]
Young MJ, Sachidanandam R, Hales DB, et al. Identification of somatic mitochondrial DNA mutations, heteroplasmy, and increased levels of catenanes in tumor specimens obtained from three endometrial cancer patients [J]. Life (Basel), 2022, 12(4): 562. DOI: 10.3390/life12040562.
[27]
Xu J, Wang X, Du Q, et al. Clinical significance of lymphatic infiltration detected by immunohistochemical double staining in patients with endometrial cancer [J]. Clin Med Insights Oncol, 2023, 17: 11795549231152308.
[28]
Stewart CL, Warner S, Ito K, et al. Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure? [J]. Curr Probl Surg, 2018, 55(9): 330-379. DOI: 10.1067/j.cpsurg.2018.08.004.
[29]
Kim SI, Yoon JH, Lee SJ, et al. Prediction of lymphovascular space invasion in patients with endometrial cancer [J]. Int J Med Sci, 2021, 18(13): 2828-2834. DOI:10.7150/ijms.60718.
[30]
Meydanli MM, Aslan K, Öz M, et al. Is it possible to develop a prediction model for lymphovascular space invasion in endometrioid endometrial cancer? [J]. Int J Gynecol Pathol, 2020, 39(3): 213-220. DOI:10.1097/pgp.0000000000000596.
[31]
Celli V, Guerreri M, Pernazza A, et al. MRI- and histologic-molecular-based radio-genomics nomogram for preoperative assessment of risk classes in endometrial cancer [J]. Cancers (Basel), 2022, 14(23): 5881. DOI: 10.3390/cancers14235881.
[32]
Capozzi VA, Sozzi G, Uccella S, et al. Novel preoperative predictive score to evaluate lymphovascular space involvement in endometrial cancer: an aid to the sentinel lymph node algorithm [J]. Int J Gynecol Cancer, 2020, 30(6): 806-812. DOI:10.1136/ijgc-2019-001016.
[33]
Luo Y, Mei D, Gong J, et al. Multiparametric MRI-based radiomics nomogram for predicting lymphovascular space invasion in endometrial carcinoma [J]. J Magn Reson Imaging, 2020, 52(4): 1257-1262. DOI:10.1002/jmri.27142.
[34]
Berek JS, Matias-Guiu X. FIGO endometrial cancer staging subcommittee, FIGO Women′s Cancer Committee. Response: FIGO staging of endometrial cancer: 2023 [J]. Int J Gynaecol Obstet, 2023, 7: 1-12. DOI:10.1002/IJGO.15046.
[1] 武壮壮, 张晓娟, 史泽洪, 史瑶, 原韶玲. 超声联合乳腺X线摄影及PR、Her-2预测高级别与中低级别乳腺导管原位癌的价值[J]. 中华医学超声杂志(电子版), 2023, 20(06): 631-635.
[2] 王亚萍, 樊菁, 侯牛牛, 凌瑞. 肿瘤浸润性淋巴细胞在HER-2阳性早期乳腺癌中的临床意义[J]. 中华乳腺病杂志(电子版), 2023, 17(04): 203-209.
[3] 马敏榕, 李聪, 周勤. 宫颈癌治疗研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 497-504.
[4] 林昌盛, 战军, 肖雪. 上皮性卵巢癌患者诊疗中基因检测及分子靶向药物治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 505-510.
[5] 王璐, 樊杨. 子宫内膜癌相关生物标志物研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 511-516.
[6] 罗晨, 宗开灿, 李世颖, 傅应亚. 微小RNA-199a-3p调控CD4T细胞表达参与肺炎支原体肺炎患儿免疫反应研究[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 569-574.
[7] 顾娟, 孙擎擎, 胡方方, 曹义娟, 祁玉娟. 子宫内膜容受性检测改善胚胎反复种植失败患者妊娠结局的临床应用[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 582-587.
[8] 范帅华, 郭伟, 郭军. 基于机器学习的决策树算法在血流感染预后预测中应用现状及展望[J]. 中华实验和临床感染病杂志(电子版), 2023, 17(05): 289-293.
[9] 邬文莉, 万约翰, 高梓君, 黎凡. 外科手术联合口服西罗莫司治疗儿童口腔颌面部淋巴管畸形[J]. 中华口腔医学研究杂志(电子版), 2023, 17(05): 345-352.
[10] 王娟, 高俊, 周伊兰, 李小红, 史兵伟, 潘美珍. 血清IL-2、IL-17和骨密度关系及其对骨质疏松症的预测价值[J]. 中华老年骨科与康复电子杂志, 2023, 09(05): 295-300.
[11] 陈科春, 吴秋义, 李建, 周寅, 徐周. 基于不同中性粒细胞与淋巴细胞比值探讨机械取栓术后首次CT征象与患者预后的关系[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(04): 215-221.
[12] 吴萌, 吴国仲, 王贵红, 端靓靓, 施杰, 王旭, 余婷, 刘伟. IgA肾病患者中性粒细胞-淋巴细胞比值与肾小管萎缩/间质纤维化相关性分析[J]. 中华临床医师杂志(电子版), 2023, 17(9): 972-979.
[13] 岳瑞雪, 孔令欣, 郝鑫, 杨进强, 韩猛, 崔国忠, 王建军, 张志生, 孔凡庭, 张维, 何文博, 李现桥, 周新平, 徐东宏, 胡崇珠. 乳腺癌HER2蛋白表达水平预测新辅助治疗疗效的真实世界研究[J]. 中华临床医师杂志(电子版), 2023, 17(07): 765-770.
[14] 符梅沙, 周玉华, 李慧, 薛春颜. 淋巴细胞免疫治疗对复发性流产患者外周血T淋巴细胞亚群分布与PD1/PD-L1表达的影响及意义[J]. 中华临床医师杂志(电子版), 2023, 17(06): 726-730.
[15] 牛文博, 吴凤鹏, 刘月平, 周超熙, 张娟, 胡旭华, 李保坤, 王贵英. 新辅助放化疗对局部进展期直肠癌疗效及肿瘤免疫微环境变化的研究[J]. 中华临床医师杂志(电子版), 2023, 17(05): 519-523.
阅读次数
全文


摘要