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中华妇幼临床医学杂志(电子版) ›› 2023, Vol. 19 ›› Issue (04) : 387 -393. doi: 10.3877/cma.j.issn.1673-5250.2023.04.003

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非编码RNA在卵泡发育成熟中作用及其机制的研究现状
周东杰, 蒋敏, 范海瑞, 高玲玲, 孔祥, 卢丹, 王丽萍†()   
  1. 扬州大学临床医学院妇产科，扬州　225001
    扬州大学动物科学与技术学院，扬州　225001
    扬州大学临床医学院生物样本库，扬州　225001
  • 收稿日期:2023-01-30 修回日期:2023-06-06 出版日期:2023-08-01
  • 通信作者: 王丽萍

Current research progress on non-coding RNA in follicular development and maturation

Dongjie Zhou, Min Jiang, Hairui Fan, Lingling Gao, Xiang Kong, Dan Lu, Liping Wang†()   

  1. Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
    Yangzhou University College of Animal Science and Technology, Yangzhou 225001, Jiangsu Province, China
    Department of Biobank, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2023-01-30 Revised:2023-06-06 Published:2023-08-01
  • Corresponding author: Liping Wang
  • Supported by:
    National Natural Science Foundation of China(82001512); General Project of Jiangsu Science and Technology Plan(BK20211118); General Project of Medical Scientific Research of Jiangsu Provincial Health Commission(M2021044); Maternal and Child Health Research Project of Jiangsu Province(F201945)
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周东杰, 蒋敏, 范海瑞, 高玲玲, 孔祥, 卢丹, 王丽萍. 非编码RNA在卵泡发育成熟中作用及其机制的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 387-393.

Dongjie Zhou, Min Jiang, Hairui Fan, Lingling Gao, Xiang Kong, Dan Lu, Liping Wang. Current research progress on non-coding RNA in follicular development and maturation[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 387-393.

进入21世纪，高通量测序技术的发展及针对非编码RNA (ncRNA)的分子生物学研究技术与方法的开发，进一步推动了ncRNA的发现。表观遗传学相关ncRNA，包括微小RNA (miRNA)、长链非编码RNA (lncRNA)及环状RNA (circRNA)等，但是这些ncRNA并不直接作为遗传信息载体，而是通过调控BMP15、GDF9基因等表达，参与颗粒细胞(GC)、卵母细胞生命活动。ncRNA对GC增殖、凋亡，卵母细胞发育成熟等，发挥着重要的调控作用，或许在多囊卵巢综合征(PCOS)相关疾病发病机制中，发挥着调控疾病进展作用。笔者拟就ncRNA对卵泡发育成熟的作用及其机制的最新研究进展进行阐述，旨在为POCS等相关生殖系统疾病的预防、早期诊断和治疗提供新思路。

关键词: RNA,长链非编码, 卵泡, 卵母细胞, 粒层细胞, 微RNAs, 女(雌)性泌尿生殖系统疾病, 多囊卵巢综合征, 女(雌)性

In the 21st century, development of high-throughput sequencing technologies and molecular biology research techniques and methods for non-coding RNA (ncRNA) have further promoted the discovery of ncRNA. Epigenetically related ncRNA include microRNAs (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), etc., however, these ncRNA are not act directly as carriers of genetic information, but involved in life activities of granulosa cells (GC)and oocytes by regulating expression of genes such as BMP15 and GDF9. ncRNA plays an important regulatory role in GC proliferation and apoptosis, oocyte development and maturation, and may play a role in regulating disease progression in pathogenesis of polycystic ovary syndrome (PCOS) related diseases. The authors intend to present the latest research progresses on ncRNA in follicular development and maturation, aiming to explore the role of ncRNA in follicular development and its mechanism, which may provide new ideas for prevention, early diagnosis and treatment of POCS and other related reproductive diseases. The authors intend to present the latest research progress on the role of ncRNA in follicular development and maturation, and its mechanism, aiming at providing new ideas for prevention, early diagnosis and treatment of POCS and other related reproductive system diseases.

Key words: RNA, long noncoding, Ovarian follicle, Oocytes, Granulosa cells, MicroRNAs, Female urogenital diseases, Polycystic ovary syndrome, Female
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