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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (02) : 145 -149. doi: 10.3877/cma.j.issn.1673-5250.2022.02.004

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Periostin在妇科恶性肿瘤中的研究现状
初磊, 郭翼, 童晓文()   
  1. 同济大学附属同济医院妇产科,上海 200065
  • 收稿日期:2021-06-26 修回日期:2022-01-10 出版日期:2022-04-01
  • 通信作者: 童晓文

Research status of periostin in gynecological malignancies

Lei Chu, Yi Guo, Xiaowen Tong()   

  1. Department of Obstetrics and Gynecology, Tongji Hospital of Tongji University, Shanghai 200065, China
  • Received:2021-06-26 Revised:2022-01-10 Published:2022-04-01
  • Corresponding author: Xiaowen Tong
  • Supported by:
    National Natural Science Foundation of China(81802583)
引用本文:

初磊, 郭翼, 童晓文. Periostin在妇科恶性肿瘤中的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2022, 18(02): 145-149.

Lei Chu, Yi Guo, Xiaowen Tong. Research status of periostin in gynecological malignancies[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(02): 145-149.

骨膜蛋白(periostin)是近年被发现的一种多功能高分子糖蛋白,主要由成骨细胞及其前体细胞分泌,也可由肿瘤细胞及癌旁细胞分泌。该蛋白是一种高度保守的功能蛋白质,参与细胞外基质(ECM)的组成,并与肿瘤细胞黏附、转移和生长密切相关,属于分泌型可溶性ECM蛋白。periostin促进肿瘤细胞生存的分子机制及其与肿瘤发生、发展的关系具有重要理论意义,而且可为肿瘤的临床检测和治疗提供新靶点。笔者拟就periostin的结构与功能,periostin高表达在妇科恶性肿瘤发生、发展中的作用机制,在卵巢癌、宫颈癌、子宫内膜癌的初步研究,以及periostin为肿瘤治疗提供新靶点等的最新研究进展进行阐述。

Periostin is a kind of multifunctional macromolecular glycoprotein discovered in recent years. It is mainly secreted by osteoblasts and their precursor cells, and can also be secreted by tumor cells and para-carcinoma cells. Periostin is a highly conserved functional protein, which participates in the formation of extracellular matrix (ECM) and is closely related to tumor cell adhesion, metastasis and growth. It is a secreted soluble ECM protein. There is great theoretical value to explore the molecular mechanism of periostin promoting tumor cell survival and its relationship with tumor occurrence and development. The findings can provide new targets for clinical detection and treatment of tumors. The author intends to review the structure and function of periostin, mechanism of highly expressed periostin in the occurrence and development of gynecological malignancies, preliminary research on highly expressed periostion in ovarian cancer, cervical cancer, and endometrial cancer, and the new target of periostin for tumor therapy.

[1]
Yamato H, Kimura K, Fukui E, et al. Periostin secreted by activated fibroblasts in idiopathic pulmonary fibrosis promotes tumorigenesis of non-small cell lung cancer[J]. Sci Rep, 2021, 11(1): 21114. DOI: 10.1038/s41598-021-00717-5.
[2]
Wei WF, Chen XJ, Liang LJ, et al. periostin+ cancer-associated fibroblasts promote lymph node metastasis by impairing the lymphatic endothelial barriers in cervical squamous cell carcinoma[J]. Mol Oncol, 2021, 15(1): 210-227. DOI: 10.1002/1878-0261.12837.
[3]
Sueyama T, Kajiwara Y, Mochizuki S, et al. Periostin as a key molecule defining desmoplastic environment in colorectal cancer[J]. Virchows Arch, 2021, 478(5): 865-874. DOI: 10.1007/s00428-020-02965-8.
[4]
Chu L, Wang F, Zhang W, et al. Periostin secreted by carcinoma-associated fibroblasts promotes ovarian cancer cell platinum resistance through the PI3K/Akt signaling pathway[J]. Technol Cancer Res Treat, 2020, 19: 1533033820977535. DOI: 10.1177/1533033820977535.
[5]
Zhong H, Li X, Zhang J, et al. Overexpression of periostin is positively associated with gastric cancer metastasis through promoting tumor metastasis and invasion[J]. J Cell Biochem, 2019, 120(6): 9927-9935. DOI: 10.1002/jcb.28275.
[6]
Ma Y, He L, Zhao X, et al. Protease activated receptor 2 signaling promotes self-renewal and metastasis in colorectal cancer through beta-catenin and periostin[J]. Cancer Lett, 2021, 521: 130-141. DOI: 10.1016/j.canlet.2021.08.032.
[7]
Ma Z, Zhao X, Deng M, et al. Bone marrow mesenchymal stromal cell-derived periostin promotes B-ALL progression by modulating CCL2 in leukemia cells[J]. Cell Rep, 2019, 26(6): 1533.e4-1543.e4. DOI: 10.1016/j.celrep.2019.01.034.
[8]
Koh SJ, Kim JW, Kim BG, et al. Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice[J]. Carcinogenesis, 2019, 40(1): 102-111. DOI: 10.1093/carcin/bgy120.
[9]
Yu B, Wu K, Wang X, et al. Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7[J]. Cell Death Dis, 2018, 9(11): 1082. DOI: 10.1038/s41419-018-1116-6.
[10]
Tang M, Liu B, Bu X, et al. Cross-talk between ovarian cancer cells and macrophages through periostin promotes macrophage recruitment[J]. Cancer Sci, 2018, 109(5): 1309-1318. DOI: 10.1111/cas.13567.
[11]
Hu WW, Chen PC, Chen JM, et al. Periostin promotes epithelial-mesenchymal transition via the MAPK/miR-381 axis in lung cancer[J]. Oncotarget, 2017, 8(37): 62248-62260. DOI: 10.18632/oncotarget.19273.
[12]
Chuanyu S, Yuqing Z, Chong X, et al. Periostin promotes migration and invasion of renal cell carcinoma through the integrin/focal adhesion kinase/c-Jun N-terminal kinase pathway[J]. Tumour Biol, 2017, 39(4): 1010428317694549. DOI: 10.1177/1010428317694549.
[13]
Kudo A. The structure of the periostin gene, its transcriptional control and alternative splicing, and protein expression[J]. Adv Exp Med Bio, 2019, 1132: 7-20. DOI: 10.1007/978-981-13-6657-4_2.
[14]
Panchamanon P, Pavasant P, Leethanakul C. Periostin plays role in force-induced stem cell potential by periodontal ligament stem cells[J]. Cell Biol Int, 2019, 43(5): 506-515. DOI: 10.1002/cbin.11116.
[15]
Landry NM, Cohen S, Dixon IMC. Periostin in cardiovascular disease and development: a tale of two distinct roles[J]. Basic Res Cardiol, 2018, 113(1): 1. DOI: 10.1007/s00395-017-0659-5.
[16]
Gonzalez-Gonzalez L, Alonso J. Periostin: a matricellular protein with multiple functions in cancer development and progression[J]. Front Oncol, 2018, 8: 225. DOI: 10.3389/fonc.2018.00225.
[17]
Wallace DP. Periostin in the kidney[J]. Adv Exp Med Biol, 2019, 1132: 99-112. DOI: 10.1007/978-981-13-6657-4_11.
[18]
Matsumoto H. Roles of periostin in asthma[J]. Adv Exp Med Biol, 2019, 1132: 145-159. DOI: 10.1007/978-981-13-6657-4_15.
[19]
Tomaru A, Kobayashi T, Hinneh JA, et al. Oligonucleotide-targeting periostin ameliorates pulmonary fibrosis[J]. Gene Ther, 2017, 24(11): 706-716. DOI: 10.1038/gt.2017.80.
[20]
Liu Y, Huang Z, Cui D, et al. The multiaspect functions of periostin in tumor progression[J]. Adv Exp Med Biol, 2019, 1132: 125-136. DOI: 10.1007/978-981-13-6657-4_13.
[21]
Han X, Wang Q, Wang Y, et al. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1/microRNA-202-3p/periostin axis modulates invasion and epithelial-mesenchymal transition in human cervical cancer[J]. J Cell Physiol, 2019, 234(8): 14170-14180. DOI: 10.1002/jcp.28113.
[22]
Sung PL, Jan YH, Lin SC, et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma[J]. Oncotarget, 2016, 7(4): 4036-4047. DOI: 10.18632/oncotarget.6700.
[23]
Sterzynska K, Kazmierczak D, Klejewski A, et al. Expression of osteoblast-specific factor 2 (OSF-2, periostin) is associated with drug resistance in ovarian cancer cell lines[J]. Int J Mol Sci, 2019, 20(16): 3927. DOI: 10.3390/ijms20163927.
[24]
Ryner L, Guan Y, Firestein R, et al. Upregulation of periostin and reactive stroma is associated with primary chemoresistance and predicts clinical outcomes in epithelial ovarian cancer[J]. Clin Cancer Res, 2015, 21(13): 2941-2951. DOI: 10.1158/1078-0432.CCR-14-3111.
[25]
Liu Y, Gao F, Song W. Periostin contributes to arsenic trioxide resistance in hepatocellular carcinoma cells under hypoxia[J]. Biomed Pharmacother, 2017, 88: 342-348. DOI: 10.1016/j.biopha.2017.01.052.
[26]
Kujawa KA, Zembala-Nożyńska E, Cortez AJ, et al. Fibronectin and periostin as prognostic markers in ovarian cancer[J]. Cells, 2020, 9(1): 149. DOI: 10.3390/cells9010149.
[27]
Unuvar S, Melekoglu R, Turkmen NB, et al. Comparison of preoperative serum neopterin, periostin, indoleamine 2,3-dioxygenase, YKL-40, and tenascin-C levels with current tumor markers for early-stage endometrial cancer[J]. Int J Gynaecol Obstet, 2021, 155(3): 417-424. DOI: 10.1002/ijgo.13666.
[28]
Zhang T, Ma G, Zhang Y, et al. miR-599 inhibits proliferation and invasion of glioma by targeting periostin[J]. Biotechnol Lett, 2017, 39(9): 1325-1333. DOI: 10.1007/s10529-017-2365-7.
[29]
Mitamura Y, Murai M, Mitoma C, et al. NRF2 activation inhibits both TGF-beta1- and IL-13-mediated periostin expression in fibroblasts: benefit of cinnamaldehyde for antifibrotic treatment[J]. Oxid Med Cell Longev, 2018: 2475047. DOI: 10.1155/2018/2475047.
[30]
Gopinath P, Natarajan A, Sathyanarayanan A, et al. The multifaceted role of matricellular proteins in health and cancer, as biomarkers and therapeutic targets[J]. Gene, 2022, 815: 146137. DOI: 10.1016/j.gene.2021.146137.
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