探讨卵巢硬化性间质瘤(OSST)的临床特点及诊治方法。

选择2010年10月至2019年5月，首都医科大学附属北京妇产医院收治的8例OSST患者为研究对象。采用回顾性分析方法，对其临床病例资料进行分析，包括临床表现、血清学肿瘤标志物、影像学检查结果、手术情况、治疗方法、病理学检查及随访结果等。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求。

对本组8例OSST患者的研究结果如下。①就诊年龄及原因：均为青少年女性(年龄为14～36岁)，体检发现盆腔肿块，伴随症状为月经不规律或月经间期出血。②血清肿瘤标志物检查：仅3例患者血清糖类抗原(CA)₁₂₅水平升高，其余均正常。③术前影像学检查：可见直径为6.7～13.5 cm的卵巢囊实性或实性肿块。④手术结果：对2例患者行腹腔镜探查术，6例行开腹探查术，术中可见单侧卵巢囊实性或实性肿块。对其中2例已婚、已育者实施开腹手术(患侧附件切除术＋大网膜活检术)；而6例未婚患者中，实施患侧附件切除术为1例，患侧卵巢肿块切除术为5例。⑤组织病理学检查结果：术中快速冰冻组织病理学检查结果提示，均无交界性或明确恶性病变，术后组织病理学检查结果均被确诊为OSST。⑥随访结果：均接受术后随访，随访时间(12～115个月)内，均无局部复发或远期转移。

OSST发病率低，但是临床误诊率较高。OSST的典型组织病理学特征是可见假小叶结构。对于高度怀疑恶性卵巢肿瘤者，应于术中对切除组织进行快速冰冻切片病理学检查以明确诊断，从而决定手术范围。

To explore the clinical features, diagnosis and treatment of ovarian sclerosing stromal tumor (OSST).

From October 2010 to May 2019, a total of 8 patients with OSST admitted to Beijing Obstetrics and Gynecology Hospital, Capital Medical University were selected into this study. The clinical data of 8 patients with OSST were analyzed retrospectively, including clinical manifestations, serum tumour marker, imaging examination results, operation conditions, treatment methods, pathological examination results and follow-up results. This study was in line with World Medical Association Declaration of Helsinki revised in 2013.

The results of 8 patients with OSST were as follows. ① Age and causes of treatment: all were young women (aged from 14 to 36 years), and physical examination revealed pelvic mass with concomitant symptoms were irregular menstruation or bleeding during menstruation. ②Examination of serum tumor markers: serum carbohydrate antigen (CA)₁₂₅ level increased in only 3 patients, and the rest were normal. ③The preoperative imaging examination: cystic solid or solid masses of ovary with a diameter of 6.7-13.5 cm were found in all patients. ④Results of operation: 2 patients underwent laparoscopic exploration and 6 patients underwent laparotomy. Unilateral ovarian solid-cystic masses or solid masses can be seen during operation. Two married patients underwent unilateral adnexectomy and omental biopsy. Among 6 unmarried patients, 1 underwent unilateral adnexectomy, and 5 underwent ovarian neoplasms resection. ⑤The results of histopathological examination: the result of intraoperative rapid freezing pathology showed no borderline or definite malignant lesions, and the results of postoperative histopathological examination were confirmed as OSST. ⑥ Results of follow-up: all patients were followed up after operation for 12-115 months, and there was no local or long-term recurrence and metastasis.

OSST has low incidence but high misdiagnosis rate. The typical pathological feature of OSST is pseudolobular pattern. For those who are highly suspected of malignant ovarian tumors, rapid intraoperative frozen pathological examination should be performed during the operation to determine the diagnosis and determine the scope of operation.