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中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (04) : 477 -482. doi: 10.3877/cma.j.issn.1673-5250.2018.04.017

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综述

母体血清学指标预测前置胎盘合并胎盘植入研究现状
朱晓童1, 蒋敏1   
  1. 1. 225001 江苏,扬州大学临床医学院妇产科
  • 收稿日期:2018-04-02 修回日期:2018-07-02 出版日期:2018-08-01

Research progress on maternal serum markers in predicting placenta previa complicated with placenta accrete

Xiaotong Zhu1, Min Jiang1   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2018-04-02 Revised:2018-07-02 Published:2018-08-01
  • About author:
    Corresponding author: Kong Xiang, Email:
  • Supported by:
    Project of Maternal and Child Health in Jiangsu Province(F201663); Postgraduate Research & Practice Innovation Program of Jiangsu Education Department(SJCX17_0633); Project of Key Research and Development Plan (Social Development) of Yangzhou Science and Technology Bureau(YZ2017069)
引用本文:

朱晓童, 蒋敏. 母体血清学指标预测前置胎盘合并胎盘植入研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2018, 14(04): 477-482.

Xiaotong Zhu, Min Jiang. Research progress on maternal serum markers in predicting placenta previa complicated with placenta accrete[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(04): 477-482.

前置胎盘合并胎盘植入是晚孕期危及母儿安全的严重疾病。目前,随着人工终止妊娠术、引产术、剖宫产术分娩等子宫手术增多,使妊娠妇女胎盘植入发生率随之上升。由于前置胎盘合并胎盘植入的临床表现缺乏特异性,故产前诊断较为困难。目前,预测前置胎盘合并胎盘植入的母体血清学指标包括肌酸激酶(CK)、甲胎蛋白(AFP)、妊娠相关蛋白(PAPP)-A、胎儿游离DNA(cffDNA)、胎盘游离mRNA、血管内皮生长因子(VEGF)、色素上皮衍生因子(PEDF),以及多项母体血清学指标联合检测等。临床对于前置胎盘合并胎盘植入的产前诊断采取母体血清学指标检测,具有创伤小、可重复等优势。笔者拟就产前母体血清学指标预测前置胎盘合并胎盘植入的研究现状进行阐述。

Placenta previa complicated with placenta accreta is one of the serious complications which can endanger maternal and infants′ lives in the third trimester. Currently, with the increase in uterine surgeries such as artificial termination of pregnancy, induction of labor, and cesarean section, the incidence of placenta accreta in pregnant women has increased. Due to the lack of specific clinical features of placenta previa complicated with placenta accreta, prenatal diagnosis of placenta previa complicated with placenta accreta is difficult. Currently, maternal serum markers in predicting placenta previa complicated with placenta accreta include creatine kinase (CK), alpha-fetoprotein (AFP), pregnancy-associated plasma protein (PAPP)-A, cell-free fetal DNA (cffDNA), and placental free mRNA, vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), and combined detection of multiple maternal serum markers. The detection of maternal serum markers has clinical advantages such as less trauma and repeatability in prenatal prediction of placenta previa complicated with placenta accreta. This article focuses on currently research development of prenatal maternal serum markers in predicting placenta previa complicated with placenta accreta.

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