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中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (04) : 470 -476. doi: 10.3877/cma.j.issn.1673-5250.2018.04.016

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综述

多囊卵巢综合征相关子宫内膜增生病变的研究进展
李小芳1, 李秀莹1, 林辉瑞1, 李荔1,()   
  1. 1. 510010 广州,广东省妇幼保健院 广州医科大学附属广东省妇儿医院妇产科
  • 收稿日期:2018-02-09 修回日期:2018-06-15 出版日期:2018-08-01
  • 通信作者: 李荔

Research status of polycystic ovary syndrome and endometrial hyperplasia

Xiaofang Li1, Xiuying Li1, Huirui Lin1, Li Li1,()   

  1. 1. Department of Obstetrics and Gynecology, Guangdong Women and Children′s Hospital of Guangzhou Medical University, Guangzhou 510010, Guangdong Province, China
  • Received:2018-02-09 Revised:2018-06-15 Published:2018-08-01
  • Corresponding author: Li Li
  • About author:
    Corresponding author: Li Li, Email:
  • Supported by:
    Science and Technology Planning Project of Departement of Science and Technology of Guangdong Province(2014A020212237); Natural Science Foundation of Guangdong Province(S2013010011984); Project of Health and Family Planning Commission of Guangdong Province(20133071); Project of Guangzhou Science and Technology Innovation Commission(201510010290); Project of Traditional Chinese Medicine Bureau of Guangdong Province(20184005)
引用本文:

李小芳, 李秀莹, 林辉瑞, 李荔. 多囊卵巢综合征相关子宫内膜增生病变的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2018, 14(04): 470-476.

Xiaofang Li, Xiuying Li, Huirui Lin, Li Li. Research status of polycystic ovary syndrome and endometrial hyperplasia[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(04): 470-476.

多囊卵巢综合征(PCOS)是育龄期妇女常见的妇科内分泌疾病,常伴有内分泌环境异常及代谢功能紊乱。对于PCOS导致子宫内膜增生病变的具体发病机制,迄今尚不清楚。近年研究结果显示,PCOS患者的内分泌及代谢异常,可能导致子宫内膜增生病变。长期高水平雌激素、胰岛素抵抗、高雄激素血症、炎症因子、肥胖、瘦素等多种危险因素,均可影响子宫内膜相关分子及基因表达异常。笔者拟就PCOS与子宫内膜增生病变相关因素的最新研究进展进行阐述。

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease in reproductive-aged women, which is usually accompanied by endocrine disorders and metabolic dysfunctions. However, its etiology and pathogenesis are not clear yet. Recent researches show that the disorder of endocrine and the abnormality of metabolism in PCOS patients may cause endometrial hyperplasia. Long-term and high-level of estrogen stimulation, insulin resistance, hyperandrogenism, inflammatory factor, obesity, leptin and other risk factors may influence the expression of molecules and genes in endometrium. This article focuses on these risk factors of PCOS and endometrial hyperplasia.

图1 胰岛素介导的PI3K信号通路激活过程
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