切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (04) : 483 -487. doi: 10.3877/cma.j.issn.1673-5250.2018.04.018

所属专题: 文献

综述

婴幼儿喘息的预防与治疗研究进展
张莉1, 訾慧芬2,()   
  1. 1. 014040 内蒙古自治区,内蒙古科技大学包头医学院;014040 内蒙古自治区,包头市中心医院儿科
    2. 014040 内蒙古自治区,包头市中心医院儿科
  • 收稿日期:2018-03-19 修回日期:2018-06-30 出版日期:2018-08-01
  • 通信作者: 訾慧芬

Research progress on prevention and treatment of wheezing in infants

Li Zhang1, Huifen Zi2,()   

  1. 1. Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, Inner Mongolia Autonomous Region, China; Department of Pediatrics, Baotou Central Hospital, Baotou 014040, Inner Mongolia Autonomous Region, China
    2. Department of Pediatrics, Baotou Central Hospital, Baotou 014040, Inner Mongolia Autonomous Region, China
  • Received:2018-03-19 Revised:2018-06-30 Published:2018-08-01
  • Corresponding author: Huifen Zi
  • About author:
    Corresponding author: Zi Huifen, Email:
引用本文:

张莉, 訾慧芬. 婴幼儿喘息的预防与治疗研究进展[J]. 中华妇幼临床医学杂志(电子版), 2018, 14(04): 483-487.

Li Zhang, Huifen Zi. Research progress on prevention and treatment of wheezing in infants[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(04): 483-487.

喘息(wheezing)是儿童时期最常见呼吸系统疾病的临床表现之一。近年儿童喘息性疾病发病率呈明显上升趋势。引起婴幼儿喘息的原因主要与呼吸道感染及婴幼儿的特异性体质有关,而喘息与哮喘发作在发病机制、危险因素等方面具有一定相关性。虽然目前尚无确切方法筛选可能发展为哮喘的喘息婴幼儿,但是已有参考指标可对喘息婴幼儿进行综合评估,并对其进行早期干预。笔者拟就婴幼儿喘息的病因及其发病机制、相关影响因素、预防、诊断及治疗等的最新研究进展进行阐述,旨在为临床降低婴幼儿喘息发作,进而降低哮喘发病率提供理论依据。

Wheezing is one of the most common clinical manifestations of childhood respiratory diseases. The incidence of wheezing in infants has been obviously rising in recent years. The causes of wheezing in infants are mainly related to respiratory infection and specific constitution of infants, and wheezing is closely related to the attack of asthma, there is a certain correlation between them in the pathogenesis and risk factors. Although there is no precise method for screening wheezing infants who may develop into asthma, some reference indicators can be used for comprehensive assessment of wheezing infants and early intervention. The latest research advances in the etiology, pathogenesis, related factors, prevention, diagnosis and treatment of wheezing in infant are elaborated in order to provide a theoretical basis for reducing the onset of wheezing in infants and thus reducing the incidence of asthma.

[1]
Alvarez-Alvarez I, Niu H, Guillen-Grima F, et al. Meta-analysis of prevalence of wheezing and recurrent wheezing in infants[J]. Allergol Immunopathol (Madr), 2018, 46(3): 210-217.
[2]
魏琳,张玉娥,金惠娣,等. 反复喘息患儿1 035例随访分析[J]. 临床儿科杂志,2014, 32(6): 532-535.
[3]
钱胜华,张莉,王晓花,等. 5岁以下儿童反复喘息发作呼吸道病原分析[J]. 临床肺科杂志,2016, 21(12): 2249-2251.
[4]
Rossi GA, Colin AA. Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing[J]. Eur Respir J, 2015, 45(3): 774-789.
[5]
Takeyama A, Hashimoto K, Sato M, et al. Clinical and epidemiologic factors related to subsequent wheezing after virus-induced lower respiratory tract infections in hospitalized pediatric patients younger than 3 years[J]. Eur J Pediatr, 2014, 173(7): 959-966.
[6]
Ding FX, Luo J, Fu Z. Research progress in the relationship between childhood wheezing and bacteria[J]. Chin J Contemp Pediatr, 2015, 17(5): 528-532.
[7]
赵志云. 儿童哮喘与肺炎支原体感染检验结果及相关性探讨[J]. 临床肺科杂志,2014, 19(8): 1497-1498.
[8]
Abrahamsson TR, Sandberg Abelius M, Forsberg A, et al. A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization[J]. Clin Exp Allergy, 2011, 41(12): 1729-1739.
[9]
江霞辉,陆俏群,赵若雯. 毛细支气管炎与哮喘患儿T淋巴细胞亚群及干扰素-γ、白介素-4的对比分析[J]. 中国妇幼保健,2013, 28(23): 3784-3786.
[10]
毛国其,蒋文良. 小儿呼吸道合胞病毒毛细支气管炎血Th17/Treg失衡机制及意义[J]. 中国妇幼健康研究,2017, 28(12): 1734-1735.
[11]
Chkhaidze I, Zirakishvili D, Shavshvishvili N, et al. Prognostic value of TH1/TH2 cytokines in infants with wheezing in a three year follow-up study[J]. Pneumonol Alergol Pol, 2016, 84(3): 144-150.
[12]
Guilbert TW, Morgan WJ, Krawiec M, et al. The prevention of early asthma in kids study: design, rationale and methods for the childhood asthma research and education network[J]. Control Clin Trials, 2004, 25(3): 286-310.
[13]
赵德育. 婴幼儿喘息流行病学及发展趋势[J]. 中国实用儿科杂志,2014, 29(6): 401-404.
[14]
Amin P, Levin L, Epstein T, et al. Optimum predictors of childhood asthma: persistent wheeze or the asthma predictive index?[J]. J Allergy Clin Immunol Pract, 2014, 2(6): 709-715.
[15]
Burbank AJ, Szefler SJ. Current and future management of the young child with early onset wheezing[J]. Curr Opin Allergy Clin Immunol, 2017, 17(2): 146-152.
[16]
Price D, Ryan D, Burden A, et al. Using fractional exhaled nitric oxide (FeNO) to diagnose steroid-responsive disease and guide asthma management in routine care[J]. Clin Transl Allergy, 2013, 3(1): 37.
[17]
蔡青,邓金强. 婴幼儿喘息性疾病FeNO检测与sIgE、IgE的相关性分析[J]. 中国医药导报,2017, 14(12): 97-100.
[18]
王红,兰常肇,马少杰,等. 婴幼儿反复喘息与血清维生素D水平相关性研究[J]. 国际儿科学杂志,2014,7(4): 421-423.
[19]
孙秋凤,蒋吴君,陈正荣,等. 血清25-羟维生素D3水平与婴儿喘息关系及临床意义探讨[J]. 中国实用儿科杂志,2015, 30(3): 199-202.
[20]
徐艳娜,顾建华,李永莲,等. 反复喘息婴幼儿维生素D3水平及与Th1/Th2细胞平衡变化的相关性研究[J]. 中华实用儿科临床杂志,2015, 30(4): 264-266.
[21]
Nenna R, Ferrara M, Nicolai A, et al. Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up[J]. Pediatr Infect Dis J, 2015, 34(10): 1131-1132.
[22]
de Sousa RB, Medeiros D, Sarinho E, et al. Risk factors for recurrent wheezing in infants: a case-control study[J]. Rev Saude Publica, 2016, 50: 15.
[23]
田曼,赵德育,文惯宇,等. RSV毛细支气管炎及其后反复相关影响因素分析[J]. 中华实验和临床病毒学杂志,2009, 23(5): 371-374.
[24]
Aranda CS, Wandalsen G, Fonzar L, et al. Risk factors for recurrent wheezing--International Study of Wheezing in Infants (EISL) phase 3[J]. Allergol Immunopathol (Madr), 2016, 44(1): 3-8.
[25]
曹向可,王维,钱庆增,等. 3岁以下婴幼儿喘息的危险因素分析[J]. 广东医学,2017, 38 (10): 1548-1551.
[26]
Miller EK, Avila PC, Khan YW, et al. Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma[J]. J Allergy Clin Immunol Pract, 2014, 2(5): 537-543.
[27]
单文婕,卢燕鸣,李亚琴,等. 婴幼儿反复喘息危险因素Meta分析[J]. 中华实用儿科临床杂志,2015, 30(10): 761-764.
[28]
Zeiger RS, Mauger D, Bacharier LB, et al. Daily or intermittent budesonide in preschool children with recurrent wheezing[J]. N Engl J Med, 2011, 365(21): 1990-2001.
[29]
Tenero L, Piazza M, Piacentini G, et al. Recurrent wheezing in children[J]. Transl Pediatr, 2016, 5(1): 31-36.
[30]
Beigelman A, Bacharier LB. Management of preschool recurrent wheezing and asthma: a phenotype-based approach[J]. Curr Opin Allergy Clin Immunol, 2017, 17(2): 131-138.
[31]
Sears MR. Predicting asthma outcomes[J]. J Allergy Clin Immunol, 2015, 136(4): 829-836.
[32]
储昭乐,彭美芳,李章. 吸入糖皮质激素预防毛细支气管炎后喘息随机对照试验的Meta分析[J/CD]. 中华临床医师杂志(电子版), 2013, 7(19): 8813-8820.
[33]
徐红艳,周罗根. 婴幼儿毛细支气管炎后喘息的干预[J]. 实用临床医药杂志,2014, 18(24): 150-160.
[34]
Peng WS, Chen X, Yang XY, et al. Systematic review of montelukast′s efficacy for reventing post-bronchiolitis wheezing[J]. Pediatr Allergy Immunol, 2014, 25(2): 143-150.
[35]
Stokholm J, Chawes BL, Vissing NH, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomised, double-blind, placebo-controlled trial[J]. Lancet Respir Med, 2016, 4(1): 19-26.
[36]
Beigelman A, Isaacson-Schmid M, Sajol G, et al. Randomized trial to evaluate azithromycin′s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis[J]. J Allergy Clin Immunol, 2015, 135(5): 1171-1178.
[37]
田野,嵇若旭,鲍一笑,等. 阿奇霉素在婴幼儿喘息联合降阶梯疗法中的疗效[J]. 中华实用儿科杂志,2014, 29(4): 261-264.
[38]
Mochizuki H, Kusuda S, Okada K, et al. Palivizumab prophylaxis in preterm infants and subsequent recurrent wheezing: 6 year follow up study[J]. Am J Respir Crit Care Med, 2017, 196(1): 29-38.
[39]
Lemanske RF Jr. Early life wheezing and respiratory syncytial virus prevention[J]. N Engl J Med, 2013, 368(19): 1839-1841.
[40]
黄花荣,曾森强,吴敬芳. 大剂量丙种球蛋白对喘息婴儿外周血IL-4和CD20水平以及喘息再发的影响[J]. 中国病理生理杂志,2010, 26(8): 1575-1578.
[41]
李缙. 静脉滴注丙种球蛋白治疗毛细支气管炎的临床疗效观察[J]. 儿科药学杂志,2017, 28(8): 32-35.
[1] 唐蜜, 蔡江晖, 罗尔丹, 郭文玫, 熊丽玲, 林永红, 邢莎莎, 杨霄. 多肽疫苗治疗乳腺癌的临床研究进展[J]. 中华乳腺病杂志(电子版), 2023, 17(05): 309-313.
[2] 张蓝心, 高天琦, 徐岭植, 李曼. 激素受体阳性/人表皮生长因子受体2阴性晚期乳腺癌的治疗进展[J]. 中华乳腺病杂志(电子版), 2022, 16(06): 365-369.
[3] 胡青, 余海燕. 胎儿宫内治疗及风险评估[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(01): 23-30.
[4] 张非红, 夏斌. 肠道菌群失调与新生儿坏死性小肠结肠炎发病机制的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(05): 523-527.
[5] 叶长缨, 谢静, 丁桂聪. 乳牙龋病的过渡性治疗研究进展[J]. 中华口腔医学研究杂志(电子版), 2023, 17(05): 365-370.
[6] 林凌, 李佩, 赵玮. 牛牙样牙发病机制的研究进展[J]. 中华口腔医学研究杂志(电子版), 2023, 17(02): 75-80.
[7] 张成仁, 杨熊飞, 杜斌斌, 柳利利, 李晶晶, 朱成章, 吴德望, 吕耀春. 转移灶不可切除的无症状结直肠癌是否行原发灶肿瘤切除术的Meta分析[J]. 中华普外科手术学杂志(电子版), 2023, 17(03): 305-310.
[8] 李玲, 于艳艳, 王玉杰, 赵凯. 毛细支气管炎患儿血清25(OH)D水平与Th17/Treg平衡的关系[J]. 中华肺部疾病杂志(电子版), 2022, 15(05): 718-720.
[9] 黄嘉明, 段红霞, 赖逾鹏, 王大吉, 刘兴娇, 沈鑫, 王梅英. 狼疮性肾炎慢性化中肾脏固有细胞的间充质化研究进展[J]. 中华肾病研究电子杂志, 2022, 11(06): 347-352.
[10] 唐凯, 刘正峰, 宋佳蔚, 卢秀珍. 角膜巩膜干凹斑的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(04): 231-235.
[11] 李文捷, 卢弘. 幼年特发性关节炎相关葡萄膜炎的研究进展[J]. 中华眼科医学杂志(电子版), 2023, 13(01): 40-44.
[12] 张坤淇, 张睿, 徐佳, 康庆林. 漂浮膝损伤的诊治进展[J]. 中华老年骨科与康复电子杂志, 2023, 09(04): 252-256.
[13] 金刚, 李英真, 施维, 李博. 帕金森病在病理生理学中的研究进展[J]. 中华脑科疾病与康复杂志(电子版), 2023, 13(05): 315-319.
[14] 王敏, 张妍, 王盈熹, 赵龙, 夏书月. 外泌体在慢性阻塞性肺疾病中的作用[J]. 中华临床实验室管理电子杂志, 2023, 11(01): 45-51.
[15] 郑茂凤, 时晶, 李婷, 徐筱青, 田金洲. 血管性帕金森综合征的临床特征及诊治研究进展[J]. 中华脑血管病杂志(电子版), 2022, 16(05): 347-350.
阅读次数
全文


摘要