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中华妇幼临床医学杂志(电子版) ›› 2017, Vol. 13 ›› Issue (05) : 601 -605. doi: 10.3877/cma.j.issn.1673-5250.2017.05.018

所属专题： 文献；

综述

双酚A对原始卵泡池动态变化影响机制的研究进展
陈宝红1, 唐露1, 袁东智2, 胡颖3,†(), 谭世桥3   
  1. 1. 610041　成都，四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室；610041　成都，四川大学华西临床医学院
    2. 610041　成都，四川大学华西基础医学与法医学院生理教研室
    3. 610041　成都，四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室
  • 收稿日期:2017-07-15 修回日期:2017-08-28 出版日期:2017-10-01
  • 通信作者: 胡颖

Effects of bisphenol A on the dynamic changes of primordial follicle pool: mechanism research progress

Baohong Chen1, Lu Tang1, Dongzhi Yuan2, Ying Hu3,†(), Shiqiao Tan3   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China；West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Physiology Teaching and Research Section, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
    3. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2017-07-15 Revised:2017-08-28 Published:2017-10-01
  • Corresponding author: Ying Hu
  • About author:
    Corresponding author: Hu Ying, Email:
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陈宝红, 唐露, 袁东智, 胡颖, 谭世桥. 双酚A对原始卵泡池动态变化影响机制的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2017, 13(05): 601-605.

Baohong Chen, Lu Tang, Dongzhi Yuan, Ying Hu, Shiqiao Tan. Effects of bisphenol A on the dynamic changes of primordial follicle pool: mechanism research progress[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2017, 13(05): 601-605.

原始卵泡是女性的基本生殖单位，也是卵母细胞储备的唯一形式。如果原始卵泡产生的数量不足，被过度、过早激活或发生闭锁，都可能导致早发性卵巢功能不全(POI)。导致POI的病因多且复杂，环境内分泌干扰物(EED)对POI等女性生殖系统疾病的影响作用，受到研究者关注。双酚A为重要的EED之一，具有弱雌激素活性。目前研究结果显示，双酚A对原始卵泡池的动态变化有一定影响。因此，笔者拟就双酚A对原始卵泡池动态变化影响机制的最新研究进展进行综述，旨在为与双酚A相关的POI等女性生殖系统疾病的预防和治疗，提供理论依据。

关键词: 内分泌干扰物, 卵泡, 卵原细胞, 早发性卵巢功能不全, 双酚A, 女(雌)性

Primordial follicle is the basic reproductive unit of women, also the only reservation form for oocyte. If the generated number of primordial follicles are insufficient, or being excessively, prematurely activated or follicular atresia occured, premature ovarian insufficiency (POI) may occur. The causes of POI are many and complicated, and the effects of environmental endocrine disruptors (EED) on POI and other diseases of female reproductive system have attracted attention of researchers. Bisphenol A, one of typical EED, has weak estrogenic activity. Accumulating evidence has suggested that bisphenol A has effects on the dynamics of primordial follicle pool. In this article, we review the latest research progress of the mechanism of bisphenol A effects on the dynamics of primordial follicle pool, to provide theoretical basis for prevention and treatment of POI and other diseases of female reproductive system.

Key words: Endocrine disruptors, Ovarian follicle, Oogonia, Premature ovarian insufficiency, Bisphenol A, Female
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