观察强化血糖控制对妊娠期糖尿病(GDM)产妇及其新生儿健康的影响。

选择2012年1月至2014年1月于武汉大学人民医院行强化血糖控制治疗的70例GDM患者为研究对象，并根据患者血糖控制水平将其分为研究组[n＝35，空腹血糖(FBG)<5.6 mmol/L＝和对照组(n＝35，FBG≥5.6 mmol/L)。本研究遵循的程序符合武汉大学人民医院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书。观察两组患者妊娠期并发症及新生儿并发症发生情况。

研究组妊娠期高血压疾病(HDP)、羊水过多、胎膜早破、感染等妊娠期并发症发生率(11.43%、5.71%、5.71%和2.86%)均显著低于对照组(31.43%、22.86%、25.71%和17.14%)，两组比较，差异有统计学意义(P<0.05)。研究组新生儿低血糖、巨大儿、宫内窘迫、头颅彩色多普勒超声检查结果异常等新生儿并发症发生率(5.71%、14.29%、8.57%和2.86%)也显著低于对照组(22.86%、37.14%、28.57%和17.14%)，两组比较，差异也有统计学意义(P<0.05)。

高血糖能够明显提高GDM患者妊娠期并发症及其新生儿并发症发生率。强化血糖控制能够有效降低GDM患者上述并发症发生率，获得良好妊娠结局。

To observe effects of improved glycemic control of gestational diabetes mellitus (GDM) on maternal and newborn health.

From January 2011 to 2014, a total of 70 pregnant women with GDM were included in the study.They were divided into research group[n=35, fasting blood glucose(FBG)<5.6 mmol/L=and control group(n=35, FBG≥5.6 mmol/L) according to their blood glucose control levels. The incidence rate of pregnancy complications and neonatal complications were compared between two groups.

The incidence rate of pregnancy complications such as hypertensive disorders in pregnancy(HDP), hydramnios, premature rupture of membranes, infections(11.43%, 5.71%, 5.71% and 5.71%) were obviously lower than those of control group(31.43%, 22.86%, 25.71% and 22.86%), and the differences were significant(P<0.05). The incidence rate of neonatal complications such as neonatal hypoglycemia, macrosomia, intrauterine distress, head ultrasound abnormal (5.71%, 14.29%, 8.57% and 2.86%) were obviously lower than those of control group(22.86%, 37.14%, 28.57% and 37.14%), and the differences were olso significant (P<0.05).

Hyperglycemia can significantly improve the incidence rates of pregnancy complications and neonatal complications in patients with GDM.The improved glycemic control in GDM patients can effectively reduce those rates.