Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2025, Vol. 21 ›› Issue (02): 245 -250. doi: 10.3877/cma.j.issn.1673-5250.2025.02.017

Review

Research progress of serum basal sex hormone level detection and pelvic ultrasound in the diagnosis of precocious puberty in girls

Jiayu Li1, Tao Yu1,()   

  1. 1. Department of Child Healthcare,Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China
  • Received:2025-01-12 Revised:2025-03-12 Published:2025-04-01
  • Corresponding author: Tao Yu

Precocious puberty in girls is a common developmental abnormal disease in the field of pediatric endocrinology,and its incidence is increasing year by year.Precocious puberty in girls is categorized into three subtypes:central precocious puberty (CPP),peripheral precocious puberty(PPP),and incomplete precocious puberty IPP).Among them,the pathological mechanism of CPP is primarily linked to the initial activation of the hypothalamic-pituitary-gonadal axis (HPGA),and its diagnosis depends on clinical manifestations,serum basal sex hormone levels and gonadotropinreleasing hormone (GnRH)stimulation test.However,due to the time-consuming,high cost,and high compliance requirements for children in GnRH stimulation testing,finding more convenient and non-invasive alternative means for screening of precocious puberty has become a research hotspot in this field.The detection of serum basal sex hormones holds significant clinical value in the screening of precocious puberty in girls,especially in evaluating the extent of HPGA activation.Given its simplicity and low cost,it can be employed as a primary screening tool for precocious puberty in girls,minimizing the need for unnecessary GnRH stimulation tests.In recent years,the application of pelvic ultrasound for diagnosing precocious puberty in girls has garnered significant focus.As a noninvasive,economical and easy to operate imaging technique,pelvic ultrasound provides an important basis for early screening and classification of precocious puberty in girls by measuring uterine volume,endometrium thickness and ovarian volume.The article systematically expounds the application value of serum basal sex hormone level detection and pelvic ultrasound in the diagnosis of precocious puberty in girls,providing a reference for pediatric clinicians in diagnosing precocious puberty in girls.

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