Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (05): 492 -496. doi: 10.3877/cma.j.issn.1673-5250.2019.05.003

Special Issue:

Special Forum

Current status of immune response of mesenchymal stem cells by regulating the polarization of macrophages

Meng He1, Juan Chen1, Jinlin Wu1,()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Disease of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2019-04-29 Revised:2019-08-02 Published:2019-10-01
  • Corresponding author: Jinlin Wu
  • About author:
    Corresponding author: Wu Jinlin, Email:
  • Supported by:
    Key Project of Health and Family Planning Commission of Sichuan Province(16ZD019)

Mesenchymal stem cells (MSC) are stem cells with abilities of self-renewal and multidirectional differentiation. In the past, MSC have been considered to achieve therapeutic effects mainly through cell replacement. However, a number of studies have shown that MSC play an important role in regulating immune response and inhibiting inflammatory response. Hypoxic ischemic encephalopathy (HIE) of neonates is an important disease that causes death and disability of neonates. Studies have proved that MSC transplantation can reduce inflammatory injury caused by ischemia and hypoxia, and accelerate nerve repair. However, the immunomodulatory effect of MSC is not innate, but closely related to the local inflammatory microenvironment. Under the stimulation of different levels of inflammatory factors, MSC may show distinct immune effects. In-depth understanding of its immune regulation mechanism is conducive to further research on its clinical application. Therefore, this article elaborates the immune regulation effect and mechanism of MSC under the stimulation of inflammatory microenvironment.

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