Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2020, Vol. 16 ›› Issue (04): 386 -391. doi: 10.3877/cma.j.issn.1673-5250.2020.04.003

Special Issue:

Forum

Neuroprotective effect of mesenchymal stem cells on neonatal hypoxic-ischemic brain damage

Jing Yuan1, Chao Yang2, Juan Chen1,()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Stem Cells and Regenerative Medicine Research Center, Sichuan Stem Cell Bank, Chengdu 610036, Sichuan Province, China
  • Received:2020-03-30 Revised:2020-07-02 Published:2020-08-01
  • Corresponding author: Juan Chen
  • About author:
    Corresponding author: Chen Juan, Email:
  • Supported by:
    Key Project of Health and Family Planning Commission of Sichuan Province(16ZD019)

Neonatal hypoxic-ischemic encephalopathy (HIE) is a kind of hypoxic-ischemic brain damage (HIBD) caused by perinatal asphyxia, and it is the main cause of acute neonatal death and long-term neurological diseases. The current strategies for treatment of HIE are symptomatic support therapy, while there is no curative treatment for HIE so far. However, the clinical efficacy of this approach is limited and cannot promote repair or regeneration of damaged nerves. Mesenchymal stem cell transplantation (MSCT), as a new strategy for the treatment of neonatal HIE, has exhibited neuroprotective effects in HIBD model animal. Its mechanism is complex, such as secreting extracellular vesicles, regulating immunity, promoting the repair and regeneration of neurons, anti-apoptosis and anti-oxidation. This article summarizes the latest research progresses on possible mechanisms of mesenchymal stem cell (MSC) in neuroprotective effect on HIBD animal disease model.

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