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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (04): 379 -386. doi: 10.3877/cma.j.issn.1673-5250.2023.04.002

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Monitoring and treatment of neonatal sepsis-induced coagulopathy

Xu Wei, Ge Zhang, Jinlin Wu†()   

  1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2023-02-05 Revised:2023-07-05 Published:2023-08-01
  • Corresponding author: Jinlin Wu
  • Supported by:
    Applied Basic Project of Science and Technology Department of Sichuan Province(2021YJ0211); Horizontal Project of Sichuan University(21H0865)
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Sepsis-induced coagulopathy (SIC) is a common disease in newborns and an important cause of neonatal death. At present, it is believed that there is a close relationship between inflammation and coagulation dysfunction in SIC newborns, but the mechanism of their interaction is still unclear, and it is lack of uniform standard treatment plan to prevent SIC in newborns with sepsis. The author intends to elaborate on the latest research progress in pathogenesis, serum monitoring indicators, and treatment of neonatal SIC, with the aim of providing reference for further clinical and basic research on SIC and improving the prognosis of newborns with SIC.

Key words: Neonatal sepsis, Fibrin fibrinogen degradation products, Thrombin, Systemic inflammatory response syndrome, Fibrinolysis, Sepsis-induced coagulopathy, Biomarkers, Infant, newborn, diseases
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