Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (03): 349 -352. doi: 10.3877/cma.j.issn.1673-5250.2019.03.017

Special Issue:

Review

Current research status of FOXL2 gene in granulocytoma of ovary

Meimei Huang1, Rutie Yin1,()   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2019-01-10 Revised:2019-04-22 Published:2019-06-01
  • Corresponding author: Rutie Yin
  • About author:
    Corresponding author: Yin Rutie, Email:
  • Supported by:
    Project of Medical Scientific Research by Development Center for Medical Science and Technology of National Health and Family Planning Commission of the People′s Republic of China(W2017QFL14)

Winged helix/forkhead transcription factor 2 (FOXL2) is an important transcription factor involved in transcription regulation of multiple target genes. FOXL2 gene is involved in ovarian development, differentiation and functional maintenance in vertebrates. In this paper, the relationship between FOXL2 gene and the occurrence and development of ovarian granulosa cell tumors (GCT) is elaborated from the aspects of FOXL2 gene structure, protein biological function and gene mutation, in order to provide new ideas for the diagnosis and treatment of ovarian GCT and lay a foundation for the research and development of new targeted drugs for ovarian GCT.

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