Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (05): 608 -611. doi: 10.3877/cma.j.issn.1673-5250.2018.05.019

Special Issue:

Review

Polyamines regulation on human and mammalian reproduction

Gege Han1, Yanqiu Hu2,()   

  1. 1. Dalian Medical University, Dalian 116000, Liaoning Province, China
    2. Northern Jiangsu People′s Hospital, Yangzhou 225000, Jiangsu Province, China
  • Received:2018-04-02 Revised:2018-07-30 Published:2018-10-01
  • Corresponding author: Yanqiu Hu
  • About author:
    Corresponding author: Hu Yanqiu, Email:
  • Supported by:
    Scientific Research Project of Jiangsu Provincial Commission of Health and Family Planning(QNRC2016347)

Polyamines are positively charged aliphatic compounds, which are involved in regulation of gene expression and cell signal transduction in human and mammalian by binding DNA, RNA and protein. Polyamines can affect the secretion of hypothalamus-pituitary-gonadal axis hormones, and then affect the quality of germ cells, luteal formation and embryonic development, and play a regulatory role in human and mammalian reproductive process, but the specific mechanisms of those effects have not been clarified. This paper focuses on the recent advances in biosynthesis, distribution and origin of polyamines, and the roles of polyamines on spermatogenesis, oogenesis, blastocyst implantation and development. The aim of this study is to provide evidences for the use of polyamines in assisted reproductive techniques (ART) to improve pregnancy outcomes.

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