Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (04): 477 -482. doi: 10.3877/cma.j.issn.1673-5250.2018.04.017

Special Issue:

Review

Research progress on maternal serum markers in predicting placenta previa complicated with placenta accrete

Xiaotong Zhu1, Min Jiang1   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2018-04-02 Revised:2018-07-02 Published:2018-08-01
  • About author:
    Corresponding author: Kong Xiang, Email:
  • Supported by:
    Project of Maternal and Child Health in Jiangsu Province(F201663); Postgraduate Research & Practice Innovation Program of Jiangsu Education Department(SJCX17_0633); Project of Key Research and Development Plan (Social Development) of Yangzhou Science and Technology Bureau(YZ2017069)

Placenta previa complicated with placenta accreta is one of the serious complications which can endanger maternal and infants′ lives in the third trimester. Currently, with the increase in uterine surgeries such as artificial termination of pregnancy, induction of labor, and cesarean section, the incidence of placenta accreta in pregnant women has increased. Due to the lack of specific clinical features of placenta previa complicated with placenta accreta, prenatal diagnosis of placenta previa complicated with placenta accreta is difficult. Currently, maternal serum markers in predicting placenta previa complicated with placenta accreta include creatine kinase (CK), alpha-fetoprotein (AFP), pregnancy-associated plasma protein (PAPP)-A, cell-free fetal DNA (cffDNA), and placental free mRNA, vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), and combined detection of multiple maternal serum markers. The detection of maternal serum markers has clinical advantages such as less trauma and repeatability in prenatal prediction of placenta previa complicated with placenta accreta. This article focuses on currently research development of prenatal maternal serum markers in predicting placenta previa complicated with placenta accreta.

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