Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (01): 109 -112. doi: 10.3877/cma.j.issn.1673-5250.2018.01.018

Special Issue:

Review

Research progress of von Willebrand factor in the pathogenesis of pre-eclampsia

Xiaojuan Chen1, Dan Lu2,(), Min Jiang2   

  1. 1. Dalian Medical University, Dalian 116044, Liaoning Province, China
    2. Clinical Medicine School of Yangzhou University, Yangzhou 225009, Jiangsu Province, China
  • Received:2017-10-15 Revised:2018-01-07 Published:2018-02-01
  • Corresponding author: Dan Lu
  • About author:
    Corresponding author: Lu Dan, Email:

Pre-eclampsia (PE) is an idiopathic hypertensive disease which frequently appear during pregnancy, and it is accompanied with multiple systemic damages such as brain, heart, liver, kidney, etc.. PE is the main cause of the increase of maternal and perinatal morbidity and mortality. At present, the exploration of the specific pathogenesis of PE is still unclear, but it is certain that when PE continues to deteriorate, it can only be improved by terminating the pregnancy timely. So understanding the pathogenesis of PE, preventing and treating PE in early stage is of great significance. von willebrand factor (vWF) is an important marker of endothelial cell injury, while domestic and overseas studies have shown that vWF may associate with PE. This paper makes a review about the roles of vWF in the pathogenesis of PE.

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