Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (03): 364 -368. doi: 10.3877/cma.j.issn.1673-5250.2017.03.022

Special Issue:

Original Article

Influence of epidural analgesia in pregnancy outcomes of single birth primipara with normal fetal position

Liping Zhang1, Hua Li1, Yindi Li1, Juan Wang1, Juanjuan Huang1, Yaling Jin2, Jiangrong Hei1,()   

  1. 1. Department of Obstetrics, Yan′an University Affiliated Hospital, Yan′an 716000, Shaanxi Province, China
    2. Department of Obstetrics and Gynecology, Fourth People′s Hospital of Shaanxi, Xi′an 710024, Shaanxi Province, China
  • Received:2017-01-13 Revised:2017-04-10 Published:2017-06-01
  • Corresponding author: Jiangrong Hei
  • About author:
    Corresponding author: Hei Jiangrong, Email:
Objective

To investigate the influence of epidural analgesia in pregnancy outcomes of single birth primipara with normal fetal position.

Methods

From January to December 2013, a total of 102 cases of single birth primiparas with normal fetal position who requested epidural analgesia in Yan′an University Hospital were enrolled into study group. And another 102 cases of single birth primiparas with normal fetal position who did not receive epidural analgesia in Yan′an University Hospital during the same period were selected as control group by simple random sampling method. The single birth primiparas with normal fetal position in study group were treated with continuous epidural injection of fentanyl for labor analgesia during vaginal delivery. While the single birth primiparas with normal fetal position in control group was not treated with any analgesia during vaginal delivery. If the single birth primiparas with normal fetal position in 2 groups turned to cesarean delivery, they were treated by epidural anesthesia. The cervix dilatation at the time of regular contractions, duration of the first stage of labor, duration of the second stage of labor, numeric rating scale (NRS) score, membrane rupture, usage of oxytocin, mode of delivery, neonatal birth weight and 1, 5 min Apgar scores after birth between the two groups were compared by statistical methods. There were no statistical differences between two groups in the age, body weight, gestational age and body height and so on (P>0.05).

Results

①The duration of first stage of labor in study group was significantly lower than that in control group, and the difference was statistically significant (t=3.46, P=0.003). There were no statistical differences between two group in duration of the second stage of labor and cervix dilatation at the time of regular contractions (P>0.05). The NRS score and pain classification at the time of epidural analgesia for 30 min in study group both were obviously lower than those in control group (at the time of regular uterine contractions), and both the differences were statistically significance (Z=2.45, P=0.021; χ2=8.84, P=0.012). ②The rate of spontaneous delivery was obviously higher than that in control group, while the rate of the cesarean delivery was obviously lower than that in control group, and both the differences were statistically significant (χ2=13.33, 13.60; P<0.001). But there were no significant differences between two groups in the rates of the forceps delivery, use of oxytocin and membrane rupture (P>0.05). ③There were no statistically significant differences between two groups in the neonatal birth weight, 1, 5 min Apgar scores after birth (P>0.05).

Conclusions

Epidural analgesia can reduce the labor pain and the rate of cesarean delivery and shorten the duration of first stage of labor in single birth primiparas with normal fetal position, at the same time it does not lead to the occurrence of neonatal adverse pregnancy outcomes.

表1 研究组与对照组单胎头位初产妇相关分娩指标比较
表2 研究组与对照组单胎头位初产妇妊娠结局比较[例数(%)]
表3 研究组与对照组单胎头位初产妇分娩新生儿的相关结局指标比较(±s)
[1]
宋丽,张英,周述芝,等. 硬膜外镇痛分娩对产程及胎儿血气的影响[J]. 实用医院临床杂志,2014, 11(6): 110-112.
[2]
赵权. 分娩镇痛的研究进展及现状分析[J]. 中国社区医师(医学专业), 2012, 14(1): 17.
[3]
Al-Khaduri MM, Abudraz RM, Rizvi SG, et al. Risk factors profile of shoulder dystocia in Oman: a case control study[J]. Oman Med J, 2014, 29(5): 325-329.
[4]
Bachiocco V, Macchiagodena C, Grillone G, et al. Pain and cognitive activity in labor[J]. Minerva Anestesiol, 1990, 56(10): 1061-1062.
[5]
Nicholson J, Groves S, Malik S, et al. 124: Early-term preventive labor induction in gravidas at increased risk for cesarean delivery-an association between 38-week preventive labor induction and improved birth outcomes[J]. Am J Obstet Gynecol, 2011, 204(Suppl 1): S63.
[6]
陈兰英. 激励式措施在镇痛分娩配合体位护理中的应用[J]. 中国农村卫生事业管理,2015, 35(11): 1467-1468.
[7]
Beilin Y, Mungall D, Hossain S, et al. Labor pain at the time of epidural analgesia and mode of delivery in nulliparous women presenting for an induction of labor[J]. Obstet Gynecol, 2009, 114(4): 764-769.
[8]
Woo JH, Kim JH, Lee GY, et al. The degree of labor pain at the time of epidural analgesia in nulliparous women influences the obstetric outcome[J]. Korean J Anesthesiol, 2015, 68(3): 249-253.
[9]
郭翠河,石承瓒,王丽峰,等. 硬膜外自控镇痛分娩与普通分娩在单胎头位初产妇中的对照分析[J]. 中外医学研究,2012, 10(24): 12-13.
[10]
张琼,林萍. 初产妇活跃期应用杜冷丁对产程及新生儿的影响[J]. 昆明医学院学报,2010, 31(5): 87-88, 91.
[11]
Woo JH, Kim JH, Lee GY, et al. The degree of labor pain at the time of epidural analgesia in nulliparous women influences the obstetric outcome[J]. Korean J Anesthesiol, 2015, 68(3): 249-253.
[12]
Kukulu K, Demirok H. Effects of epidural anesthesia on labor progress[J]. Pain Manag Nurs, 2008, 9(1): 10-16.
[13]
Bilir A. Single dose epidural morphine instead of patient-controlled epidural analgesia in the second day of cesarean section; an easy method for the pain relief of a new mother[J]. Clin Exp Obstet Gynecol, 2013, 40(1): 118-121.
[14]
Jeong EH, Park KH, Ryu A, et al. Clinical and sonographic parameters at mid-trimester and the risk of cesarean delivery in low-risk nulliparas[J]. J Clin Ultrasound, 2014, 43(4): 235-242.
[15]
Mayberry LJ, Clemmens D, De A. Epidural analgesia side effects, co-interventions, and care of women during childbirth: a systematic review[J]. Am J Obstet Gynecol, 2002, 186(5 Suppl Nature): S81-S93.
[16]
冯红星. 分娩早期使用自控硬膜外镇痛对分娩结局的影响[J]. 中国妇幼保健,2007, 22(13): 1755-1756.
[17]
李晋琼. 硬膜外镇痛分娩对妊娠结局的影响[J]. 中国疼痛医学杂志,2015, 21(3): 239-240.
[18]
毛辉,李春梅. 全产程分娩镇痛对分娩过程及结局的影响[J]. 中国医药科学,2011, 1(2): 87-88.
[19]
宋丽华,尚丽新,曲冬颖,等. 硬膜外镇痛分娩172例临床观察[J]. 中国实用妇科与产科杂志,2005, 21(10): 637-638.
[20]
Yayci F, Yayci E, Devrim S, et al. A prospective trial of epidural versus intravenous meperidine analgesia during labor: effects on perinatal and maternal outcome[J]. Healthmed, 2012, 6(10): 3268-3274.
[21]
Impey L, MacQuillan K, Robson M. Epidural analgesia need not increase operative delivery rates[J]. Am J Obstet Gynecol, 2000, 182(2): 358-363.
[22]
Alexander JM, Sharma SK, McIntire DD, et al. Intensity of labor pain and cesarean delivery[J]. Anesth Analg, 2001, 92(6): 1524-1528.
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