Influences of bed rest time after in vitro fertilization-embryo transfer on pregnancy outcomes

doi:10.3877/cma.j.issn.1673-5250.2017.01.015

Objective

To explore the influences of different bed rest time after in vitro fertilization-embryo transfer (IVF-ET) on pregnancy outcomes.

Methods

From June 2010 to June 2014, a total of 2 262 cycles of 2 262 infertility patients in Center of Reproductive Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School were selected as research subjects. According to the different bed rest times after embryo transfer, they were divided into 4 groups: group A (755 cycles, left the hospital after 10 minutes of bed rest), group B (526 cycles, left the hospital after 30 minutes of bed rest ), group C (506 cycles, left the hospital after 1 hour of bed rest) and group D (475 cycles, left the hospital after 2 hours of bed rest). Fertility rate, embryo implantation rate, clinical pregnancy rate among 4 groups were compared by statistical methods. Before IVF-ET, all the patients signed the informed consents, and this study was in line with the ethics standards promulgated by the human subjects committee of Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School.

Results

①There were no statistically significant differences among 4 groups in the age, infertility duration, the number of retrieved oocytes and soon (P>0.05). ②The fertility rates of group A, B, C and D were 87.4% (6 377/7 293), 87.8% (4 792/5 455), 86.9% (4 306/4 954) and 87.1% (4 036/4 636), respectively. The embryo implantation rates were 49.3% (715/1 450), 49.2% (497/1 010), 48.9% (480/982) and 48.4% (448/926), respectively. The clinical pregnancy rates were 70.6% (533/755), 69.0% (363/526), 70.4% (356/506) and 68.0% (323/475), respectively. There were no statistically significant differences among 4 groups in fertility rate, embryo implantation rate and clinical pregnancy rate (χ²=2.455, P=0.483; χ²=0.221, P=0.974; χ²=1.151, P=0.765).

Conclusions

To take early ambulation or to stay in bed for a short time after embryo transfer does not affect the pregnancy outcomes of IVF-ET. It is more scientific and reasonable to arrange the need for bed rest and bed rest time individually according to the physical and psychological status of the patients after embryo transfer.

Key words: Fertilization in vitro, Embryo transfer, Bed rest, Pregnancy rate, Women

表1 4组不孕患者基本临床资料比较(±s)

组别	周期数(个)	年龄(岁)	不孕年限(年)	获卵数(个)
A组	755	32.4±4.3	5.7±3.1	9.7±5.2
B组	526	31.3±5.5	5.4±3.4	10.4±5.7
C组	506	30.8±5.3	5.0±3.4	9.8±4.6
D组	475	32.1±4.8	5.9±3.1	9.8±5.1
F值	?	0.217	1.890	0.181
P值	?	0.611	0.223	0.236

表1 4组不孕患者基本临床资料比较(±s)

组别	周期数(个)	年龄(岁)	不孕年限(年)	获卵数(个)
A组	755	32.4±4.3	5.7±3.1	9.7±5.2
B组	526	31.3±5.5	5.4±3.4	10.4±5.7
C组	506	30.8±5.3	5.0±3.4	9.8±4.6
D组	475	32.1±4.8	5.9±3.1	9.8±5.1
F值	?	0.217	1.890	0.181
P值	?	0.611	0.223	0.236

表2 4组不孕患者胚胎种植及妊娠结局比较[%(例数/例数′)]

组别	周期数(个)	受精率	胚胎种植率	临床妊娠率
A组	755	87.4(6 377/7 293)	49.3(715/1 450)	70.6(533/755)
B组	526	87.8(4 792/5 455)	49.2(497/1 010)	69.0(363/526)
C组	506	86.9(4 306/4 954)	48.9(480/982)	70.4(356/506)
D组	475	87.1(4 036/4 636)	48.8(448/926)	68.0(323/475)
χ²值	?	2.455	0.221	1.151
P值	?	0.483	0.974	0.765

表2 4组不孕患者胚胎种植及妊娠结局比较[%(例数/例数′)]

组别	周期数(个)	受精率	胚胎种植率	临床妊娠率
A组	755	87.4(6 377/7 293)	49.3(715/1 450)	70.6(533/755)
B组	526	87.8(4 792/5 455)	49.2(497/1 010)	69.0(363/526)
C组	506	86.9(4 306/4 954)	48.9(480/982)	70.4(356/506)
D组	475	87.1(4 036/4 636)	48.8(448/926)	68.0(323/475)
χ²值	?	2.455	0.221	1.151
P值	?	0.483	0.974	0.765

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