Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (05): 609 -612. doi: 10.3877/cma.j.issn.1673-5250.2015.05.012

Special Issue:

Original Article

Research of cytogenetics factors on recurrent spontaneous abortion couples

Luping Ouyang1, Hongqian Huang1, Tiansheng Liu1, Dongmei Fei1, Shaoke Chen1, Chenguang Zheng1()   

  1. 1. Guangxi Obstetrics and Gynecology Hospital/Women and Children Care Hospital, Genetic Metabolic Center, Nanning 530003, Guangxi Province, China.
  • Received:2015-06-25 Revised:2015-09-10 Published:2015-10-01
  • Corresponding author: Chenguang Zheng
  • About author:
    Corresponding author: Zheng Chenguang, Email:
Objective

To analyze the results of chromosome test in recurrent spontaneous abortion(RSA) couples, and investigate the relationship between RSA and chromosome abnormality.

Methods

From 1st January 2012 to 31st December 2014, a total of 1 180 RSA couples (2 360 cases) were included in the study.Their chromosome karyotype were analyzed by G banding technology. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Guangxi Obstetrics and Gynecology Hospital. Informed consent was obtained from each participates.

Results

189 cases (8.0%) were found abnormal chromosome, there were 107 female cases and 82 male cases among them.In those 189 patients with chromosomal abnormalities, 38 cases (20.1%) were founded abnormal chromosome structurewere, including 26 cases of balanced translocation chromosomes, 7 cases robertsonian translocation, 4 cases chromosome inversion and 1 case chromosome deletion.Meanwhile, 151 cases(79.9%) were founded chromosome polymorphism.It contained 103 cases of secondary constriction increase, 21 cases of inv(9) chromosomal inversion, 17 cases with the body of trabant chromosome increase, 5 cases of trabant chromosome and 5 cases of chromosome centromeric heterochromatin increase.

Conclusions

Chromosome abnormality is one of important genetic factors lead to RSA. Chromosome polymorphism should be more attention in RSA.

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