To investigate the effect of lymphocytes active immunotherapy on recurrent spontaneous abortion (RSA) and its nursing measures.

From April 2010 to September 2011, a total of 154 RSA cases who underwent lymphocytes active immunotherapy treatment were included into this study. The procedure of this treatment were the following, peripheral blood lymphocytes of husband (healthy individuals) were collected. If the spouse should not be used as immunogen, then selected unrelated healthy individuals lymphocytes. The standard of the efficacy was the maintenance of pregnancy to 20 gestation weeks. The nursing measures were: improve the registration and management system, good psychological counseling and strict care practices. All of the 154 patients completed the follow-up. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Affiliated Hospital of Luzhou Medical College. Informed consent was obtained from each participate.

①After receiving two courses of immune therapy, positive for anti-phospholipid antibody (APLA) was 146 cases (94.81%), there had significant difference between before and after the treatment (P<0.01). ② Among 154 patients, 136 cases(88.31%) were re-pregnancy; pregnancy to 20 weeks after the 98 cases, 28 cases in the course of treatment in pregnancy.

Lymphocytes active immunotherapy is safe and effective. But whether it is worthy of clinical application, further studies are needed to confirm. The improvement of the registration and management system, good psychological counseling, strict care practices and timely guidance of the health care strategy can improve the quality of care to the patients.