Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (03): 407 -410. doi: 10.3877/cma.j.issn.1673-5250.2015.03.026

Special Issue:

Review

Research progress on antiepileptic drugs in the treatment of Tourette's syndrome in children

Chunsong Yang1, Lingli Zhang2(), Hong Huang2(), Cairong Zhu3   

  1. 1. Department of Pharmacy, Evidence-based Pharmacy Center, West China Second University Hospital, Chengdu 610041, Sichuan Province, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu 610041, Sichuan Province, China; West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Department of Pharmacy, Evidence-based Pharmacy Center, West China Second University Hospital, Chengdu 610041, Sichuan Province, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu 610041, Sichuan Province, China
    3. West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-01-11 Revised:2015-04-29 Published:2015-06-01
  • Corresponding author: Lingli Zhang, Hong Huang
  • About author:
    Corresponding author: Zhang Lingli, Email:

Tourette syndrome (TS) is a common childhood-onset neuropsychiatric disorder, which is characterized by repeated episodes of involuntary multiple motor and phonic tics. The most commonly prescribed drugs are typical antipsychotics, benzamides, atypical antipsychotics and α2 adrenoceptor agonist for patients with TS. However, drugs are limited due to the frequent occurrence of adverse events. The current studies showed antiepileptic drugs (AED) were effective for control tics. For example, topiramate is a potential drug, but the side effects were unclear, and levetiracetam could not be recommend as the rational use of valproic acid for children with TS. Future research needs to confirm AED either as monotherapy or add-on therapy which is effective on the control of tic.

[1]
Stern JS, Burza S, Robertson MM. Gilles de la Tourette's syndrome and its impact in the UK[J]. Postgrad Med J, 2005, 81(951): 12–19.
[2]
Roessner V, Plessen KJ, Rothenberger A, et al. European clinical guidelines for Tourette syndrome and other tic disorders. Part Ⅱ:pharmacological treatment[J]. Eur Child Adolesc Psychiatry, 2011, 20(4): 173–196.
[3]
Cavanna AE, Seri S. Tourette's syndrome[J]. BMJ, 2013, 347: f4964.
[4]
Robertson MM, Eapen V, Cavanna AE. The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective[J]. J Psychosom Res, 2009, 67(6): 475–483.
[5]
Sullivan S, Rai D, Golding J, et al. The association between autism spectrum disorder and psychotic experiences in the Avon longitudinal study of parents and children (ALSPAC) birth cohort[J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(8): 806–814.e2.
[6]
Knight T, Steeves T, Day L, et al. Prevalence of tic disorders: a systematic review and meta-analysis[J]. Pediatr Neurol, 2012, 47(2): 77–90.
[7]
Felling RJ, Singer HS. Neurobiology of Tourette syndrome: current status and need for further investigation[J]. J Neurosci, 2011, 31(35): 12387–12395.
[8]
Robertson MM, Stern JS. Gilles de la Tourette syndrome: symptomatic treatment based on evidence[J]. Eur Child Adolesc Psychiatry, 2000, 9(Suppl 1): I60–I75.
[9]
Correll CU, Leucht S, Kane JM. Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies[J]. Am J Psychiatry, 2004, 161(3): 414–425.
[10]
Fedorowicz VJ, Fombonne E. Metabolic side effects of atypical antipsychotics in children: a literature review[J]. J Psychopharmacol, 2005, 19(5): 533–550.
[11]
Jankovic J, Jimenez-Shahed J, Brown LW. A randomised, double-blind, placebo-controlled study of topiramate in the treatment of Tourette syndrome[J]. J Neurol Neurosurg Psychiatry, 2010, 81(1): 70–73.
[12]
Deckers CL, Czuczwar SJ, Hekster YA, et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed[J]. Epilepsia, 2000,41(11): 1364–1374.
[13]
Pandey S, Rathore C, Michael BD. Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis[J]. Cochrane Database Syst Rev, 2014, 10: CD010247.
[14]
Wiffen PJ, Derry S, Moore RA, et al. Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews[J]. Cochrane Database Syst Rev, 2013, 11: CD010567.
[15]
Awaad Y, Michon AM, Minarik S. Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome[J]. Mov Disord, 2005, 20(6): 714–718.
[16]
Fernández-Jaén A, Fernández-Mayoralas DM, Muoz-Jareo N, et al. An open-label, prospective study of levetiracetam in children and adolescents with Tourette syndrome[J]. Eur J Paediatr Neurol, 2009, 13(6): 541–545.
[17]
Poulain P, Margineanu DG. Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones[J]. Neuropharmacology,2002,42(3): 346–352.
[18]
Rigo JM, Hans G, Nguyen L,et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents[J]. Br J Pharmacol, 2002, 136(5): 659–672.
[19]
Toth M. The epsilon theory: a novel synthesis of the underlying molecular and electrophysiological mechanisms of primary generalized epilepsy and the possible mechanism of action of valproate[J]. Med Hypotheses, 2005, 64(2): 267–272.
[20]
Ondo WG, Jankovic J, Connor GS, et al. Topiramate in essential tremor: a double-blind, placebo-controlled trial[J]. Neurology, 2006, 66(5): 672–677.
[21]
Abuzzahab FS, Brown VL. Control of Tourette's syndrome with topiramate[J]. Am J Psychiatry, 2001, 158(6): 968.
[22]
Kuo SH, Jimenez-Shahed J. Topiramate in treatment of tourette syndrome[J]. Clin Neuropharmacol, 2010, 33(1): 32–34.
[23]
Yang CS, Zhang LL, Zeng LN, et al. Topiramate for Tourette's syndrome in children: a meta-analysis[J]. Pediatr Neurol, 2013, 49(5): 344–350.
[24]
Awaad Y, Michon AM, Minarik S. Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome[J]. Mov Disord, 2005, 20(6): 714–718.
[25]
Fernández-Jaén A, Fernández-Mayoralas DM, Muoz-Jareo N, et al. An open-label, prospective study of levetiracetam in children and adolescents with Tourette syndrome[J]. Eur J Paediatr Neurol, 2009, 13(6): 541–545.
[26]
Smith-Hicks CL, Bridges DD, Paynter NP, et al. A double blind randomized placebo control trial of levetiracetam in Tourette syndrome[J]. Mov Disord, 2007, 22(12): 1764–1770.
[27]
Hedderick EF, Morris CM, Singer HS. Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome[J]. Pediatr Neurol, 2009, 40(6): 420–425.
[28]
Ye L, Lippmann S. Tourette disorder treated with valproic acid[J]. Clin Neuropharmacol, 2014, 37(1): 36–37.
[29]
Yang CS, Zhang LL, Lin YZ, et al. Sodium valproate for the treatment of Tourette's syndrome in children: a systematic review and meta-analysis[J]. Psychiatry Res, 2015, 226(2-3): 411–417.
[30]
Swain JE, Leckman JF. Tourette's syndrome in children[J]. Curr Treat Options Neurol, 2003, 5(4): 299–308.
[31]
Goetz CG. Clonidine and clonazepam in Tourette syndrome[J]. Adv Neurol, 1992, 58: 245–251.
[32]
Cavanna AE, Nani A. Antiepileptic drugs and Tourette syndrome[J]. Int Rev Neurobiol, 2013, 112: 373–389.
[33]
Gonce M, Barbeau A. Seven cases of Gilles de la Tourette's syndrome: partial relief with clonazepam: a pilot study[J]. Can J Neurol Sci, 1977, 4(4): 279–283.
[34]
Steingard RJ, Goldberg M, Lee D, et al. Adjunctive clonazepam treatment of tic symptoms in children with comorbid tic disorders and ADHD[J]. J Am Acad Child Adolesc Psychiatry, 1994, 33(3): 394–399.
[35]
Lee HW, Jung DK, Suh CK, et al. Cognitive effects of low-dose topiramate monotherapy in epilepsy patients: A 1-year follow-up[J]. Epilepsy Behav, 2006, 8(4): 736–741.
[36]
Eddy CM, Rickards HE, Cavanna AE. Behavioral adverse effects of antiepileptic drugs in epilepsy[J]. J Clin Psychopharmacol, 2012, 32(3): 362–375.
[37]
Mula M, Cavanna AE, Monaco F. Psychopharmacology of topiramate: from epilepsy to bipolar disorder[J]. Neuropsychiatr Dis Treat, 2006, 2(4): 475–488.
[38]
Gomer B, Wagner K, Frings L, et al. The influence of antiepileptic drugs on cognition: a comparison of levetiracetam with topiramate[J]. Epilepsy Behav, 2007, 10(3): 486–494.
[39]
Huang CW, Pai MC, Tsai JJ. Comparative cognitive effects of levetiracetam and topiramate in intractable epilepsy[J]. Psychiatry Clin Neurosci, 2008, 62(5): 548–553.
[40]
Levisohn PM, Mintz M, Hunter SJ, et al. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, noninferiority trial[J]. Epilepsia, 2009, 50(11): 2377–2389.
[41]
Piazzini A, Chifari R, Canevini MP, et al. Levetiracetam: an improvement of attention and of oral fluency in patients with partial epilepsy[J]. Epilepsy Res, 2006, 68(3): 181–188.
[42]
Piedad J, Rickards H, Besag FM, et al. Beneficial and adverse psychotropic effects of antiepileptic drugs in patients with epilepsy: a summary of prevalence, underlying mechanisms and data limitations[J]. CNS Drugs, 2012, 26(4): 319–335.
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