Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (03): 407 -410. doi: 10.3877/cma.j.issn.1673-5250.2015.03.026

Special Issue:

Review

Research progress on antiepileptic drugs in the treatment of Tourette's syndrome in children

Chunsong Yang1, Lingli Zhang2(), Hong Huang2(), Cairong Zhu3   

  1. 1. Department of Pharmacy, Evidence-based Pharmacy Center, West China Second University Hospital, Chengdu 610041, Sichuan Province, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu 610041, Sichuan Province, China; West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Department of Pharmacy, Evidence-based Pharmacy Center, West China Second University Hospital, Chengdu 610041, Sichuan Province, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu 610041, Sichuan Province, China
    3. West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-01-11 Revised:2015-04-29 Published:2015-06-01
  • Corresponding author: Lingli Zhang, Hong Huang
  • About author:
    Corresponding author: Zhang Lingli, Email:

Tourette syndrome (TS) is a common childhood-onset neuropsychiatric disorder, which is characterized by repeated episodes of involuntary multiple motor and phonic tics. The most commonly prescribed drugs are typical antipsychotics, benzamides, atypical antipsychotics and α2 adrenoceptor agonist for patients with TS. However, drugs are limited due to the frequent occurrence of adverse events. The current studies showed antiepileptic drugs (AED) were effective for control tics. For example, topiramate is a potential drug, but the side effects were unclear, and levetiracetam could not be recommend as the rational use of valproic acid for children with TS. Future research needs to confirm AED either as monotherapy or add-on therapy which is effective on the control of tic.

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